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Entry version 62 (07 Oct 2020)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

Acetyl-CoA carboxylase 2 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigaseARBA annotation
LigandManganeseARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Acetyl-CoA carboxylase 2 variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q59GJ9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q59GJ9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini119 – 193Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini926 – 1256CoA carboxyltransferase N-terminalInterPro annotationAdd BLAST331
Domaini1260 – 1576CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST317

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034733, AcCoA_carboxyl
IPR013537, AcCoA_COase_cen
IPR000089, Biotin_lipoyl
IPR029045, ClpP/crotonase-like_dom_sf
IPR011763, COA_CT_C
IPR011762, COA_CT_N
IPR011053, Single_hybrid_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08326, ACC_central, 1 hit
PF00364, Biotin_lipoyl, 1 hit
PF01039, Carboxyl_trans, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51230, SSF51230, 1 hit
SSF52096, SSF52096, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50968, BIOTINYL_LIPOYL, 1 hit
PS50989, COA_CT_CTER, 1 hit
PS50980, COA_CT_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59GJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LPFLLKPPQT LPSPDAMFRT CMTDFLHSLE RGQVLPADSL LNLVDVELIY
60 70 80 90 100
GGVKYILKVA RQSLTMFVLI MNGCHIEIDA HRLNDGGLLL SYNGNSYTTY
110 120 130 140 150
MKEEVDSYRI TIGNKTCVFE KENDPTVLRS PSAGKLTQYT VEDGGHVEAG
160 170 180 190 200
SSYAEMEVMK MIMTLNVQER GRVKYIKRPG AVLEAGCVVA RLELDDPSKV
210 220 230 240 250
HPAEPFTGEL PAQQTLPILG EKLHQVFHSV LENLTNVMSG FCLPEPVFSI
260 270 280 290 300
KLKEWVQKLM MTLRHPSLPL LELQEIMTSV AGRIPAPVEK SVRRVMAQYA
310 320 330 340 350
SNITSVLCQF PSQQIATILD CHAATLQRKA DREVFFINTQ SIVQLVQRYR
360 370 380 390 400
SGIRGYMKTV VLDLLRRYLR VEHHFQQAHY DKCVINLREQ FKPDMSQVLD
410 420 430 440 450
CIFSHAQVAK KNQLVIMLID ELCGPDPSLS DELISILNEL TQLSKSEHCK
460 470 480 490 500
VALRARQILI ASHLPSYELR HNQVESIFLS AIDMYGHQFC PENLKKLILS
510 520 530 540 550
ETTIFDVLPT FFYHANKVVC MASLEVYVRR GYIAYELNSL QHRQLPDSTC
560 570 580 590 600
VVEFQFMLPS SHPNRMTVPI SITNPDLLRH STELFMDSGF SPLCQRMGAM
610 620 630 640 650
VAFRRFEDFT RNFDEVISCF ANVPKDTPLF SEARTSLYSE DDCKSLREEP
660 670 680 690 700
IHILNVSIQC ADHLEDEALV PILRTFVQSK KNILVDYGLR RITFLIAQEK
710 720 730 740 750
EFPKFFTFRA RDEFAEDRIY RHLEPALAFQ LELNRMRNFD LTAVPCANHK
760 770 780 790 800
MHLYLGAAKV KEGVEVTDHR FFIRAIIRHS DLITKEASFE YLQNEGERLL
810 820 830 840 850
LEAMDELEVA FNNTSVRTDC NHIFLNFVPT VIMDPFKIEE SVRYMVMRYG
860 870 880 890 900
SRLWKLRVLQ AEVKINIRQT TTGSAVPIRL FITNESGYYL DISLYKEVTD
910 920 930 940 950
SRSGNIMFHS FGNKQGPQHG MLINTPYVTK DLLQAKRFQA QTLGTTYIYD
960 970 980 990 1000
FPEMFRQALF KLWGSPDKYP KDILTYTELV LDSQGQLVEM NRLPGGNEVG
1010 1020 1030 1040 1050
MVAFKMRFKT QEYPEGRDVI VIGNDITFRI GSFGPGEDLL YLRASEMARA
1060 1070 1080 1090 1100
EGIPKIYVAA NSGARIGMAE EIKHMFHVAW VDPEDPHKGF KYLYLTPQDY
1110 1120 1130 1140 1150
TRISSLNSVH CKHIEEGGES RYMITDIIGK DDGLGVENLR GSGMIAGESS
1160 1170 1180 1190 1200
LAYEEIVTIS LVTCRAIGIG AYLVRLGQRV IQVENSHIIL TGASALNKVL
1210 1220 1230 1240 1250
GREVYTSNNQ LGGVQIMHYN GVSHITVPDD FEGVYTILEW LSYMPKDNHS
1260 1270 1280 1290 1300
PVPIITPTDP IDREIEFLPS RAPYDPRWML AGRPHPTLKG TWQSGFFDHG
1310 1320 1330 1340 1350
SFKEIMAPWA QTVVTGRARL GGIPVGVIAV ETRTVEVAVP ADPANLDSEA
1360 1370 1380 1390 1400
KIIQQAGQVW FPDSAYKTAQ AIKDFNREKL PLMIFANWRG FSGGMKDMYD
1410 1420 1430 1440 1450
QVLKFGAYIV DGLRQYKQPI LIYIPPYAEL RGGSWVVIDA TINPLCIEMY
1460 1470 1480 1490 1500
ADKESRGGVL EPEGTVEIKF RKKDLIKSMR RIDPAYKKLM EQLGEPDLSD
1510 1520 1530 1540 1550
KDRKDLEGRL KAREDLLLPI YHQVAVQFAD FHDTPGRMLE KGVISDILEW
1560 1570 1580 1590 1600
KTARTFLYWR LRRLLLEDQV KQEILQASGE LSHVHIQSML RRWFVETEGA
1610 1620 1630 1640 1650
VKAYLWDNNQ VVVQWLEQHW QAGDGPRSTI RENITYLKHD SVLKTIRGLV
1660 1670 1680
EENPEVAVDC VIYLSQHISP AERAQVVHLL STMDSPAST
Length:1,689
Mass (Da):192,354
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD3BB8598E35DDB7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB209110 mRNA Translation: BAD92347.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209110 mRNA Translation: BAD92347.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ59GJ9

Miscellaneous databases

EvolutionaryTraceiQ59GJ9

Family and domain databases

InterProiView protein in InterPro
IPR034733, AcCoA_carboxyl
IPR013537, AcCoA_COase_cen
IPR000089, Biotin_lipoyl
IPR029045, ClpP/crotonase-like_dom_sf
IPR011763, COA_CT_C
IPR011762, COA_CT_N
IPR011053, Single_hybrid_motif
PfamiView protein in Pfam
PF08326, ACC_central, 1 hit
PF00364, Biotin_lipoyl, 1 hit
PF01039, Carboxyl_trans, 1 hit
SUPFAMiSSF51230, SSF51230, 1 hit
SSF52096, SSF52096, 2 hits
PROSITEiView protein in PROSITE
PS50968, BIOTINYL_LIPOYL, 1 hit
PS50989, COA_CT_CTER, 1 hit
PS50980, COA_CT_NTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59GJ9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59GJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 7, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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