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Entry version 94 (02 Dec 2020)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

Eukaryotic translation initiation factor 4 gamma, 3 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factorImportedARBA annotation
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4 gamma, 3 variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27724

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q59GJ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q59GJ0, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1416 – 1538MIInterPro annotationAdd BLAST123
Domaini1611 – 1780W2InterPro annotationAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 67DisorderedSequence analysisAdd BLAST67
Regioni128 – 232DisorderedSequence analysisAdd BLAST105
Regioni324 – 386DisorderedSequence analysisAdd BLAST63
Regioni403 – 427DisorderedSequence analysisAdd BLAST25
Regioni500 – 527DisorderedSequence analysisAdd BLAST28
Regioni762 – 815DisorderedSequence analysisAdd BLAST54
Regioni881 – 906DisorderedSequence analysisAdd BLAST26
Regioni924 – 945DisorderedSequence analysisAdd BLAST22
Regioni1055 – 1075DisorderedSequence analysisAdd BLAST21
Regioni1212 – 1237DisorderedSequence analysisAdd BLAST26
Regioni1267 – 1414DisorderedSequence analysisAdd BLAST148

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili710 – 730Sequence analysisAdd BLAST21
Coiled coili1611 – 1631Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi160 – 202PolarSequence analysisAdd BLAST43
Compositional biasi212 – 232PolarSequence analysisAdd BLAST21
Compositional biasi332 – 348PolyampholyteSequence analysisAdd BLAST17
Compositional biasi367 – 383Pro-richSequence analysisAdd BLAST17
Compositional biasi505 – 521PolarSequence analysisAdd BLAST17
Compositional biasi784 – 798PolarSequence analysisAdd BLAST15
Compositional biasi1281 – 1322PolarSequence analysisAdd BLAST42
Compositional biasi1383 – 1397PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4G family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
594395at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR037585, EIF4G3
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23253:SF23, PTHR23253:SF23, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59GJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VKKIHRHRLS PATEKGAASS GEGDKDPPPP AHEDIAVKGT ATAAGTGPGT
60 70 80 90 100
GAAAAAAAAV PPPHPAAAAA AAAAAAAAAA AVPPPHPNIR ALQTQAPQQI
110 120 130 140 150
PRGPVQQPLE DRIFTPAVSA VYSTVTQVAR QPGTPTPSPY SAHEINKGHP
160 170 180 190 200
NLAATPPGHA SSPGLSQTPY PSGQNAGPTT LVYPQTPQTM NSQPQTRSPG
210 220 230 240 250
GFRPIQFFQR PQIQPPRATI PNSSPSIRPG AQTPTAVYQA NQHIMMVNHL
260 270 280 290 300
PMPYPVPQGP QYCIPQYRHS GPPYVGPPQQ YPVQPPGPGP FYPGPGPGDF
310 320 330 340 350
PNAYGTPFYP SQPVYQSAPI IVPTQQQPPP AKREKKTIRI RDPNQGGKDI
360 370 380 390 400
TEEIMSGGGS RNPTPPIGRP TSTPTPPQLP SQVPEHSPVV YGTVESAHLA
410 420 430 440 450
ASTPVTAASD QKQEEKPKPD PVLKSPSPVL RLVLSGEKKE QEGQTSETTA
460 470 480 490 500
IVSIAELPLP PSPTTVSSVA RSTIAAPTSS ALSSQPIFTT AIDDRCELSS
510 520 530 540 550
PREDTIPIPS LTSCTETSDP LPTNENDDDI CKKPCSVAPN DIPLVSSTNL
560 570 580 590 600
INEINGVSEK LSATESIVEI VKQEVLPLTL ELEILENPPE EMKLECIPAP
610 620 630 640 650
ITPSTVPSFP PTPPTPPASP PHTPVIVPAA ATTVSSPSAA ITVQRVLEED
660 670 680 690 700
ESIRTCLSED AKEIQNKIEV EADGQTEEIL DSQNLNSRRS PVPAQIAITV
710 720 730 740 750
PKTWKKPKDR TRTTEEMLEA ELELKAEEEL SIDKVLESEQ DKMSQGFHPE
760 770 780 790 800
RDPSDLKKVK AVEENGEEAE PVRNGAESVS EGEGIDANSG STDSSGDGVT
810 820 830 840 850
FPFKPESWKP TDTEGKKQYD REFLLDFQFM PACIQKPEGL PPISDVVLDK
860 870 880 890 900
INQPKLPMRT LDPRILPRGP DFTPAFADFG RQTPGGRGVP LLNVGSRRSQ
910 920 930 940 950
PGQRREPRKI ITVSVKEDVH LKKAENAWKP SQKRDSQADD PENIKTQELF
960 970 980 990 1000
RKVRSILNKL TPQMFNQLMK QVSGLTVDTE ERLKGVIDLV FEKAIDEPSF
1010 1020 1030 1040 1050
SVAYANMCRC LVTLKVPMAD KPGNTVNFRK LLLNRCQKEF EKDKADDDVF
1060 1070 1080 1090 1100
EKKQKELEAA SAPEERTRLH DELEEAKDKA RRRSIGNIKF IGELFKLKML
1110 1120 1130 1140 1150
TEAIMHDCVV KLLKNHDEES LECLCRLLTT IGKDLDFEKA KPRMDQYFNQ
1160 1170 1180 1190 1200
MEKIVKERKT SSRIRFMLQD VIDLRLCNWV SRRADQGPKT IEQIHKEAKI
1210 1220 1230 1240 1250
EEQEEQRKVQ QLMTKEKRRP GVQRVDEGGW NTVQGAKNSR VLDPSKFLKI
1260 1270 1280 1290 1300
TKPTIDEKIQ LVPKAQLGSW GKGSSGGAKA SETDALRSSA SSLNRFSALQ
1310 1320 1330 1340 1350
PPAPSGSTPS TPVEFDSRRT LTSRGSMGRE KNDKPLPSAT ARPNTFMRGG
1360 1370 1380 1390 1400
SSKDLLDNQS QEEQRREMLE TVKQLTGGVD VERNSTEAER NKTRESAKPE
1410 1420 1430 1440 1450
ISAMSAHDKA ALSEEELERK SKSIIDEFLH INDFKEAMQC VEELNAQGLL
1460 1470 1480 1490 1500
HVFVRVGVES TLERSQITRD HMGQLLYQLV QSEKLSKQDF FKGFSETLEL
1510 1520 1530 1540 1550
ADDMAIDIPH IWLYLAELVT PMLKEGGISM RELTIEFSKP LLPVGRAGVL
1560 1570 1580 1590 1600
LSEILHLLCK QMSHKKVGAL WREADLSWKD FLPEGEDVHN FLLEQKLDFI
1610 1620 1630 1640 1650
ESDSPCSSEA LSKKELSAEE LYKRLEKLII EDKANDEQIF DWVEANLDEI
1660 1670 1680 1690 1700
QMSSPTFLRA LMTAVCKAAI IADSSTFRVD TAVIKQRVPI LLKYLDSDTE
1710 1720 1730 1740 1750
KELQALYALQ ASIVKLDQPA NLLRMFFDCL YDEEVISEDA FYKWESSKDP
1760 1770 1780
AEQNGKGVAL KSVTAFFTWL REAEEESEDN
Length:1,780
Mass (Da):195,958
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65102752AEE27684
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB209119 mRNA Translation: BAD92356.1

NCBI Reference Sequences

More...
RefSeqi
NP_001185730.1, NM_001198801.1
NP_001185731.1, NM_001198802.1
NP_003751.2, NM_003760.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8672

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8672

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209119 mRNA Translation: BAD92356.1
RefSeqiNP_001185730.1, NM_001198801.1
NP_001185731.1, NM_001198802.1
NP_003751.2, NM_003760.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ59GJ0

Genome annotation databases

GeneIDi8672
KEGGihsa:8672

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8672
PharmGKBiPA27724

Phylogenomic databases

OrthoDBi594395at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8672, 3 hits in 850 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8672

Gene expression databases

GenevisibleiQ59GJ0, HS

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR037585, EIF4G3
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain
PANTHERiPTHR23253:SF23, PTHR23253:SF23, 1 hit
PfamiView protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit
SMARTiView protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit
SUPFAMiSSF48371, SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59GJ0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59GJ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: December 2, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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