Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q59GJ0 (Q59GJ0_HUMAN)

Entry version 94 (02 Dec 2020)
Sequence version 1 (26 Apr 2005)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Eukaryotic translation initiation factor 4 gamma, 3 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factorImportedARBA annotation
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4 gamma, 3 variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27724

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q59GJ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q59GJ0, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1416 – 1538MIInterPro annotationAdd BLAST123
Domaini1611 – 1780W2InterPro annotationAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 67DisorderedSequence analysisAdd BLAST67
Regioni128 – 232DisorderedSequence analysisAdd BLAST105
Regioni324 – 386DisorderedSequence analysisAdd BLAST63
Regioni403 – 427DisorderedSequence analysisAdd BLAST25
Regioni500 – 527DisorderedSequence analysisAdd BLAST28
Regioni762 – 815DisorderedSequence analysisAdd BLAST54
Regioni881 – 906DisorderedSequence analysisAdd BLAST26
Regioni924 – 945DisorderedSequence analysisAdd BLAST22
Regioni1055 – 1075DisorderedSequence analysisAdd BLAST21
Regioni1212 – 1237DisorderedSequence analysisAdd BLAST26
Regioni1267 – 1414DisorderedSequence analysisAdd BLAST148

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili710 – 730Sequence analysisAdd BLAST21
Coiled coili1611 – 1631Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi160 – 202PolarSequence analysisAdd BLAST43
Compositional biasi212 – 232PolarSequence analysisAdd BLAST21
Compositional biasi332 – 348PolyampholyteSequence analysisAdd BLAST17
Compositional biasi367 – 383Pro-richSequence analysisAdd BLAST17
Compositional biasi505 – 521PolarSequence analysisAdd BLAST17
Compositional biasi784 – 798PolarSequence analysisAdd BLAST15
Compositional biasi1281 – 1322PolarSequence analysisAdd BLAST42
Compositional biasi1383 – 1397PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4G family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		594395at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR037585, EIF4G3
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain

The PANTHER Classification System

More...PANTHERi		PTHR23253:SF23, PTHR23253:SF23, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59GJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VKKIHRHRLS PATEKGAASS GEGDKDPPPP AHEDIAVKGT ATAAGTGPGT 
        60         70         80         90        100
GAAAAAAAAV PPPHPAAAAA AAAAAAAAAA AVPPPHPNIR ALQTQAPQQI 
       110        120        130        140        150
PRGPVQQPLE DRIFTPAVSA VYSTVTQVAR QPGTPTPSPY SAHEINKGHP 
       160        170        180        190        200
NLAATPPGHA SSPGLSQTPY PSGQNAGPTT LVYPQTPQTM NSQPQTRSPG 
       210        220        230        240        250
GFRPIQFFQR PQIQPPRATI PNSSPSIRPG AQTPTAVYQA NQHIMMVNHL 
       260        270        280        290        300
PMPYPVPQGP QYCIPQYRHS GPPYVGPPQQ YPVQPPGPGP FYPGPGPGDF 
       310        320        330        340        350
PNAYGTPFYP SQPVYQSAPI IVPTQQQPPP AKREKKTIRI RDPNQGGKDI 
       360        370        380        390        400
TEEIMSGGGS RNPTPPIGRP TSTPTPPQLP SQVPEHSPVV YGTVESAHLA 
       410        420        430        440        450
ASTPVTAASD QKQEEKPKPD PVLKSPSPVL RLVLSGEKKE QEGQTSETTA 
       460        470        480        490        500
IVSIAELPLP PSPTTVSSVA RSTIAAPTSS ALSSQPIFTT AIDDRCELSS 
       510        520        530        540        550
PREDTIPIPS LTSCTETSDP LPTNENDDDI CKKPCSVAPN DIPLVSSTNL 
       560        570        580        590        600
INEINGVSEK LSATESIVEI VKQEVLPLTL ELEILENPPE EMKLECIPAP 
       610        620        630        640        650
ITPSTVPSFP PTPPTPPASP PHTPVIVPAA ATTVSSPSAA ITVQRVLEED 
       660        670        680        690        700
ESIRTCLSED AKEIQNKIEV EADGQTEEIL DSQNLNSRRS PVPAQIAITV 
       710        720        730        740        750
PKTWKKPKDR TRTTEEMLEA ELELKAEEEL SIDKVLESEQ DKMSQGFHPE 
       760        770        780        790        800
RDPSDLKKVK AVEENGEEAE PVRNGAESVS EGEGIDANSG STDSSGDGVT 
       810        820        830        840        850
FPFKPESWKP TDTEGKKQYD REFLLDFQFM PACIQKPEGL PPISDVVLDK 
       860        870        880        890        900
INQPKLPMRT LDPRILPRGP DFTPAFADFG RQTPGGRGVP LLNVGSRRSQ 
       910        920        930        940        950
PGQRREPRKI ITVSVKEDVH LKKAENAWKP SQKRDSQADD PENIKTQELF 
       960        970        980        990       1000
RKVRSILNKL TPQMFNQLMK QVSGLTVDTE ERLKGVIDLV FEKAIDEPSF 
      1010       1020       1030       1040       1050
SVAYANMCRC LVTLKVPMAD KPGNTVNFRK LLLNRCQKEF EKDKADDDVF 
      1060       1070       1080       1090       1100
EKKQKELEAA SAPEERTRLH DELEEAKDKA RRRSIGNIKF IGELFKLKML 
      1110       1120       1130       1140       1150
TEAIMHDCVV KLLKNHDEES LECLCRLLTT IGKDLDFEKA KPRMDQYFNQ 
      1160       1170       1180       1190       1200
MEKIVKERKT SSRIRFMLQD VIDLRLCNWV SRRADQGPKT IEQIHKEAKI 
      1210       1220       1230       1240       1250
EEQEEQRKVQ QLMTKEKRRP GVQRVDEGGW NTVQGAKNSR VLDPSKFLKI 
      1260       1270       1280       1290       1300
TKPTIDEKIQ LVPKAQLGSW GKGSSGGAKA SETDALRSSA SSLNRFSALQ 
      1310       1320       1330       1340       1350
PPAPSGSTPS TPVEFDSRRT LTSRGSMGRE KNDKPLPSAT ARPNTFMRGG 
      1360       1370       1380       1390       1400
SSKDLLDNQS QEEQRREMLE TVKQLTGGVD VERNSTEAER NKTRESAKPE 
      1410       1420       1430       1440       1450
ISAMSAHDKA ALSEEELERK SKSIIDEFLH INDFKEAMQC VEELNAQGLL 
      1460       1470       1480       1490       1500
HVFVRVGVES TLERSQITRD HMGQLLYQLV QSEKLSKQDF FKGFSETLEL 
      1510       1520       1530       1540       1550
ADDMAIDIPH IWLYLAELVT PMLKEGGISM RELTIEFSKP LLPVGRAGVL 
      1560       1570       1580       1590       1600
LSEILHLLCK QMSHKKVGAL WREADLSWKD FLPEGEDVHN FLLEQKLDFI 
      1610       1620       1630       1640       1650
ESDSPCSSEA LSKKELSAEE LYKRLEKLII EDKANDEQIF DWVEANLDEI 
      1660       1670       1680       1690       1700
QMSSPTFLRA LMTAVCKAAI IADSSTFRVD TAVIKQRVPI LLKYLDSDTE 
      1710       1720       1730       1740       1750
KELQALYALQ ASIVKLDQPA NLLRMFFDCL YDEEVISEDA FYKWESSKDP 
      1760       1770       1780
AEQNGKGVAL KSVTAFFTWL REAEEESEDN
Length:1,780
Mass (Da):195,958
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65102752AEE27684
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB209119 mRNA Translation: BAD92356.1

NCBI Reference Sequences

More...RefSeqi		NP_001185730.1, NM_001198801.1
NP_001185731.1, NM_001198802.1
NP_003751.2, NM_003760.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8672

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8672

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209119 mRNA Translation: BAD92356.1
RefSeqiNP_001185730.1, NM_001198801.1
NP_001185731.1, NM_001198802.1
NP_003751.2, NM_003760.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PRIDEiQ59GJ0

Genome annotation databases

GeneIDi8672
KEGGihsa:8672

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8672
PharmGKBiPA27724

Phylogenomic databases

OrthoDBi594395at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8672, 3 hits in 850 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8672

Gene expression databases

GenevisibleiQ59GJ0, HS

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR037585, EIF4G3
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain
PANTHERiPTHR23253:SF23, PTHR23253:SF23, 1 hit
PfamiView protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit
SMARTiView protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit
SUPFAMiSSF48371, SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59GJ0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59GJ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: December 2, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again