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UniProtKB - Q59GD8 (Q59GD8_HUMAN)

Entry version 139 (25 May 2022)
Sequence version 1 (26 Apr 2005)
Previous versions | rss
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Protein
Submitted name:

Calcium channel, voltage-dependent, L type, alpha 1D subunit variant

Gene

CACNA1D

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotationARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium channel, voltage-dependent, L type, alpha 1D subunit variantImported
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNA1D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1391, CACNA1D

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000157388

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei56 – 78HelicalSequence analysisAdd BLAST23
Transmembranei216 – 234HelicalSequence analysisAdd BLAST19
Transmembranei254 – 277HelicalSequence analysisAdd BLAST24
Transmembranei346 – 365HelicalSequence analysisAdd BLAST20
Transmembranei418 – 445HelicalSequence analysisAdd BLAST28
Transmembranei580 – 598HelicalSequence analysisAdd BLAST19
Transmembranei618 – 638HelicalSequence analysisAdd BLAST21
Transmembranei650 – 676HelicalSequence analysisAdd BLAST27
Transmembranei696 – 726HelicalSequence analysisAdd BLAST31
Transmembranei823 – 848HelicalSequence analysisAdd BLAST26
Transmembranei902 – 920HelicalSequence analysisAdd BLAST19
Transmembranei932 – 952HelicalSequence analysisAdd BLAST21
Transmembranei1042 – 1060HelicalSequence analysisAdd BLAST19
Transmembranei1134 – 1157HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000157388

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA84

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62658

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157388, Expressed in middle temporal gyrus and 171 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1291 – 1325Ca_chan_IQInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni122 – 153DisorderedSequence analysisAdd BLAST32
Regioni459 – 543DisorderedSequence analysisAdd BLAST85
Regioni1352 – 1371DisorderedSequence analysisAdd BLAST20
Regioni1377 – 1497DisorderedSequence analysisAdd BLAST121
Regioni1565 – 1612DisorderedSequence analysisAdd BLAST48
Regioni1801 – 1845DisorderedSequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1252 – 1272Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi135 – 153Polar residuesSequence analysisAdd BLAST19
Compositional biasi459 – 481Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi496 – 515Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi516 – 531Acidic residuesSequence analysisAdd BLAST16
Compositional biasi1390 – 1405Polar residuesSequence analysisAdd BLAST16
Compositional biasi1430 – 1459Polar residuesSequence analysisAdd BLAST30
Compositional biasi1475 – 1497Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1568 – 1601Basic and acidic residuesSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154839

Database of Orthologous Groups

More...OrthoDBi		172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.350, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031688, CAC1F_C
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR005452, LVDCC_a1dsu
IPR014873, VDCC_a1su_IQ
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16885, CAC1F_C, 2 hits
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00167, CACHANNEL
PR01636, LVDCCALPHA1D

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All

Q59GD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ANGTECRSGW VGPNGGITNF DNFAFAMLTV FQCITMEGWT DVLYWMNDAM 
        60         70         80         90        100
GFELPWVYFV SLVIFGSFFV LNLVLGVLSG EFSKEREKAK ARGDFQKLRE 
       110        120        130        140        150
KQQLEEDLKG YLDWITQAED IDPENEEEGG EEGKRNTSMP TSETESVNTE 
       160        170        180        190        200
NVSGEGENRG CCGSLWCWWR RRGAAKAGPS GCRRWGQAIS KSKLSRRWRR 
       210        220        230        240        250
WNRFNRRRCR AAVKSVTFYW LVIVLVFLNT LTISSEHYNQ PDWLTQIQDI 
       260        270        280        290        300
ANKVLLALFT CEMLVKMYSL GLQAYFVSLF NRFDCFVVCG GITETILVEL 
       310        320        330        340        350
EIMSPLGISV FRCVRLLRIF KVTRHWTSLS NLVASLLNSM KSIASLLLLL 
       360        370        380        390        400
FLFIIIFSLL GMQLFGGKFN FDETQTKRST FDNFPQALLT VFQILTGEDW 
       410        420        430        440        450
NAVMYDGIMA YGGPSSSGMI VCIYFIILFI CGNYILLNVF LAIAVDNLAD 
       460        470        480        490        500
AESLNTAQKE EAEEKERKKI ARKESLENKK NNKPEVNQIA NSDNKVTIDD 
       510        520        530        540        550
YREEDEDKDP YPPCDVPVGE EEEEEEEDEP EVPAGPRPRR ISELNMKEKI 
       560        570        580        590        600
APIPEGSAFF ILSKTNPIRV GCHKLINHHI FTNLILVFIM LSSAALAAED 
       610        620        630        640        650
PIRSHSFRNT ILGYFDYAFT AIFTVEILLK MTTFGAFLHK GAFCRNYFNL 
       660        670        680        690        700
LDMLVVGVSL VSFGIQSSAI SVVKILRVLR VLRPLRAINR AKGLKHVVQC 
       710        720        730        740        750
VFVAIRTIGN IMIVTTLLQF MFACIGVQLF KGKFYRCTDE AKSNPEECRG 
       760        770        780        790        800
LFILYKDGDV DSPVVRERIW QNSDFNFDNV LSAMMALFTV STFEGWPALL 
       810        820        830        840        850
YKAIDSNGEN IGPIYNHRVE ISIFFIIYII IVAFFMMNIF VGFVIVTFQE 
       860        870        880        890        900
QGEKEYKNCE LDKNQRQCVE YALKARPLRR YIPKNPYQYK FWYVVNSSPF 
       910        920        930        940        950
EYMMFVLIML NTLCLAMQHY EQSKMFNDAM DILNMVFTGV FTVEMVLKVI 
       960        970        980        990       1000
AFKPKHYFTD AWNTFDALIV VGSVVDIAIT EVNPTESENV PVPTATPGNS 
      1010       1020       1030       1040       1050
EESNRISITF FRLFRVMRLV KLLSRGEGIR TLLWTFIKSF QALPYVALLI 
      1060       1070       1080       1090       1100
AMLFFIYAVI GMQMFGKVAM RDNNQINRNN NFQTFPQAVL LLFRCATGEA 
      1110       1120       1130       1140       1150
WQEIMLACLP GKLCDPESDY NPGEEYTCGS NFAIVYFISF YMLCAFLIIN 
      1160       1170       1180       1190       1200
LFVAVIMDNF DYLTRDWSIL GPHHLDEFKR IWSEYDPEAK GRIKHLDVVT 
      1210       1220       1230       1240       1250
LLRRIQPPLG FGKLCPHRVA CKRLVAMNMP LNSDGTVMFN ATLFALVRTA 
      1260       1270       1280       1290       1300
LKIKTEGNLE QANEELRAVI KKIWKKTSMK LLDQVVPPAG DDEVTVGKFY 
      1310       1320       1330       1340       1350
ATFLIQDYFR KFKKRKEQGL VGKYPAKNTT IALQAGLRTL HDIGPEIRRA 
      1360       1370       1380       1390       1400
ISCDLQDDEP EETKREEEDD VFKRNGALLG NHVNHVNSDR RDSLQQTNTT 
      1410       1420       1430       1440       1450
HRPLHVQRPS IPPASDTEKP LFPPAGNSVC HNHHNHNSIG KQVPTSTNAN 
      1460       1470       1480       1490       1500
LNNANMSKAA HGKRPSIGNL EHVSENGHHS SHKHDREPQR RSSVKRTRYY 
      1510       1520       1530       1540       1550
ETYIRSDSGD EQLPTICRED PEIHGYFRDP HCLGEQEYFS SEECYEDDSS 
      1560       1570       1580       1590       1600
PTWSRQNYGY YSRYPGRNID SERPRGYHHP QGFLEDDDSP VCYDSRRSPR 
      1610       1620       1630       1640       1650
RRLLPPTPAS HRRSSFNFEC LRRQSSQEEV PSSPIFPHRT ALPLHLMQQQ 
      1660       1670       1680       1690       1700
IMAVAGLDSS KAQKYSPSHS TRSWATPPAT PPYRDWTPCY TPLIQVEQSE 
      1710       1720       1730       1740       1750
ALDQVNGSLP SLHRSSWYTD EPDISYRTFT PASLTVPSSF RNKNSDKQRS 
      1760       1770       1780       1790       1800
ADSLVEAVLI SEGLGRYARD PKFVSATKHE IADACDLTID EMESAASTLL 
      1810       1820       1830       1840       1850
NGNVRPRANG DVGPLSHRQD YELQDFGPGY SDEEPDPGRD EEDLADEMIC 

ITTL
Length:1,854
Mass (Da):211,464
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73DE6B07DF531A39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q01668CAC1D_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D CACH3, CACN4, CACNL1A2, CCHL1A2
2,161Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUN6A0A1B0GUN6_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
2,146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTN0A0A1B0GTN0_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
2,170Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUB6A0A1B0GUB6_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
1,647Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQ56A0A1W2PQ56_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
1,643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GWE1A0A1B0GWE1_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
1,372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTP8A0A1B0GTP8_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
490Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GW98A0A1B0GW98_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
453Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUH2A0A1B0GUH2_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4S8H7C4S8_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC005905 Genomic DNA No translation available.
AC012467 Genomic DNA No translation available.
AC024149 Genomic DNA No translation available.
AC092035 Genomic DNA No translation available.
AC112218 Genomic DNA No translation available.
AC132810 Genomic DNA No translation available.
AB209171 mRNA Translation: BAD92408.1

NCBI Reference Sequences

More...RefSeqi		NP_000711.1, NM_000720.3
NP_001122312.1, NM_001128840.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000481478.1; ENSP00000418014.1; ENSG00000157388.20

Database of genes from NCBI RefSeq genomes

More...GeneIDi		776

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:776

UCSC genome browser

More...UCSCi		uc062ksr.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005905 Genomic DNA No translation available.
AC012467 Genomic DNA No translation available.
AC024149 Genomic DNA No translation available.
AC092035 Genomic DNA No translation available.
AC112218 Genomic DNA No translation available.
AC132810 Genomic DNA No translation available.
AB209171 mRNA Translation: BAD92408.1
RefSeqiNP_000711.1, NM_000720.3
NP_001122312.1, NM_001128840.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

ProteomicsDBi62658

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4062, 319 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		776

Genome annotation databases

EnsembliENST00000481478.1; ENSP00000418014.1; ENSG00000157388.20
GeneIDi776
KEGGihsa:776
UCSCiuc062ksr.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		776
HGNCiHGNC:1391, CACNA1D
OpenTargetsiENSG00000157388
PharmGKBiPA84
VEuPathDBiHostDB:ENSG00000157388

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000154839
OrthoDBi172471at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		776, 14 hits in 1077 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CACNA1D, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		776

Gene expression databases

BgeeiENSG00000157388, Expressed in middle temporal gyrus and 171 other tissues

Family and domain databases

Gene3Di1.20.120.350, 3 hits
InterProiView protein in InterPro
IPR031688, CAC1F_C
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR005452, LVDCC_a1dsu
IPR014873, VDCC_a1su_IQ
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16885, CAC1F_C, 2 hits
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01636, LVDCCALPHA1D
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59GD8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59GD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 25, 2022
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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