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Entry version 139 (25 May 2022)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

Calcium channel, voltage-dependent, L type, alpha 1D subunit variant

Gene

CACNA1D

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotationARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium channel, voltage-dependent, L type, alpha 1D subunit variantImported
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNA1D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1391, CACNA1D

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000157388

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei56 – 78HelicalSequence analysisAdd BLAST23
Transmembranei216 – 234HelicalSequence analysisAdd BLAST19
Transmembranei254 – 277HelicalSequence analysisAdd BLAST24
Transmembranei346 – 365HelicalSequence analysisAdd BLAST20
Transmembranei418 – 445HelicalSequence analysisAdd BLAST28
Transmembranei580 – 598HelicalSequence analysisAdd BLAST19
Transmembranei618 – 638HelicalSequence analysisAdd BLAST21
Transmembranei650 – 676HelicalSequence analysisAdd BLAST27
Transmembranei696 – 726HelicalSequence analysisAdd BLAST31
Transmembranei823 – 848HelicalSequence analysisAdd BLAST26
Transmembranei902 – 920HelicalSequence analysisAdd BLAST19
Transmembranei932 – 952HelicalSequence analysisAdd BLAST21
Transmembranei1042 – 1060HelicalSequence analysisAdd BLAST19
Transmembranei1134 – 1157HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000157388

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA84

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62658

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157388, Expressed in middle temporal gyrus and 171 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1291 – 1325Ca_chan_IQInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni122 – 153DisorderedSequence analysisAdd BLAST32
Regioni459 – 543DisorderedSequence analysisAdd BLAST85
Regioni1352 – 1371DisorderedSequence analysisAdd BLAST20
Regioni1377 – 1497DisorderedSequence analysisAdd BLAST121
Regioni1565 – 1612DisorderedSequence analysisAdd BLAST48
Regioni1801 – 1845DisorderedSequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1252 – 1272Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi135 – 153Polar residuesSequence analysisAdd BLAST19
Compositional biasi459 – 481Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi496 – 515Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi516 – 531Acidic residuesSequence analysisAdd BLAST16
Compositional biasi1390 – 1405Polar residuesSequence analysisAdd BLAST16
Compositional biasi1430 – 1459Polar residuesSequence analysisAdd BLAST30
Compositional biasi1475 – 1497Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1568 – 1601Basic and acidic residuesSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154839

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031688, CAC1F_C
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR005452, LVDCC_a1dsu
IPR014873, VDCC_a1su_IQ
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16885, CAC1F_C, 2 hits
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL
PR01636, LVDCCALPHA1D

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All

Q59GD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ANGTECRSGW VGPNGGITNF DNFAFAMLTV FQCITMEGWT DVLYWMNDAM
60 70 80 90 100
GFELPWVYFV SLVIFGSFFV LNLVLGVLSG EFSKEREKAK ARGDFQKLRE
110 120 130 140 150
KQQLEEDLKG YLDWITQAED IDPENEEEGG EEGKRNTSMP TSETESVNTE
160 170 180 190 200
NVSGEGENRG CCGSLWCWWR RRGAAKAGPS GCRRWGQAIS KSKLSRRWRR
210 220 230 240 250
WNRFNRRRCR AAVKSVTFYW LVIVLVFLNT LTISSEHYNQ PDWLTQIQDI
260 270 280 290 300
ANKVLLALFT CEMLVKMYSL GLQAYFVSLF NRFDCFVVCG GITETILVEL
310 320 330 340 350
EIMSPLGISV FRCVRLLRIF KVTRHWTSLS NLVASLLNSM KSIASLLLLL
360 370 380 390 400
FLFIIIFSLL GMQLFGGKFN FDETQTKRST FDNFPQALLT VFQILTGEDW
410 420 430 440 450
NAVMYDGIMA YGGPSSSGMI VCIYFIILFI CGNYILLNVF LAIAVDNLAD
460 470 480 490 500
AESLNTAQKE EAEEKERKKI ARKESLENKK NNKPEVNQIA NSDNKVTIDD
510 520 530 540 550
YREEDEDKDP YPPCDVPVGE EEEEEEEDEP EVPAGPRPRR ISELNMKEKI
560 570 580 590 600
APIPEGSAFF ILSKTNPIRV GCHKLINHHI FTNLILVFIM LSSAALAAED
610 620 630 640 650
PIRSHSFRNT ILGYFDYAFT AIFTVEILLK MTTFGAFLHK GAFCRNYFNL
660 670 680 690 700
LDMLVVGVSL VSFGIQSSAI SVVKILRVLR VLRPLRAINR AKGLKHVVQC
710 720 730 740 750
VFVAIRTIGN IMIVTTLLQF MFACIGVQLF KGKFYRCTDE AKSNPEECRG
760 770 780 790 800
LFILYKDGDV DSPVVRERIW QNSDFNFDNV LSAMMALFTV STFEGWPALL
810 820 830 840 850
YKAIDSNGEN IGPIYNHRVE ISIFFIIYII IVAFFMMNIF VGFVIVTFQE
860 870 880 890 900
QGEKEYKNCE LDKNQRQCVE YALKARPLRR YIPKNPYQYK FWYVVNSSPF
910 920 930 940 950
EYMMFVLIML NTLCLAMQHY EQSKMFNDAM DILNMVFTGV FTVEMVLKVI
960 970 980 990 1000
AFKPKHYFTD AWNTFDALIV VGSVVDIAIT EVNPTESENV PVPTATPGNS
1010 1020 1030 1040 1050
EESNRISITF FRLFRVMRLV KLLSRGEGIR TLLWTFIKSF QALPYVALLI
1060 1070 1080 1090 1100
AMLFFIYAVI GMQMFGKVAM RDNNQINRNN NFQTFPQAVL LLFRCATGEA
1110 1120 1130 1140 1150
WQEIMLACLP GKLCDPESDY NPGEEYTCGS NFAIVYFISF YMLCAFLIIN
1160 1170 1180 1190 1200
LFVAVIMDNF DYLTRDWSIL GPHHLDEFKR IWSEYDPEAK GRIKHLDVVT
1210 1220 1230 1240 1250
LLRRIQPPLG FGKLCPHRVA CKRLVAMNMP LNSDGTVMFN ATLFALVRTA
1260 1270 1280 1290 1300
LKIKTEGNLE QANEELRAVI KKIWKKTSMK LLDQVVPPAG DDEVTVGKFY
1310 1320 1330 1340 1350
ATFLIQDYFR KFKKRKEQGL VGKYPAKNTT IALQAGLRTL HDIGPEIRRA
1360 1370 1380 1390 1400
ISCDLQDDEP EETKREEEDD VFKRNGALLG NHVNHVNSDR RDSLQQTNTT
1410 1420 1430 1440 1450
HRPLHVQRPS IPPASDTEKP LFPPAGNSVC HNHHNHNSIG KQVPTSTNAN
1460 1470 1480 1490 1500
LNNANMSKAA HGKRPSIGNL EHVSENGHHS SHKHDREPQR RSSVKRTRYY
1510 1520 1530 1540 1550
ETYIRSDSGD EQLPTICRED PEIHGYFRDP HCLGEQEYFS SEECYEDDSS
1560 1570 1580 1590 1600
PTWSRQNYGY YSRYPGRNID SERPRGYHHP QGFLEDDDSP VCYDSRRSPR
1610 1620 1630 1640 1650
RRLLPPTPAS HRRSSFNFEC LRRQSSQEEV PSSPIFPHRT ALPLHLMQQQ
1660 1670 1680 1690 1700
IMAVAGLDSS KAQKYSPSHS TRSWATPPAT PPYRDWTPCY TPLIQVEQSE
1710 1720 1730 1740 1750
ALDQVNGSLP SLHRSSWYTD EPDISYRTFT PASLTVPSSF RNKNSDKQRS
1760 1770 1780 1790 1800
ADSLVEAVLI SEGLGRYARD PKFVSATKHE IADACDLTID EMESAASTLL
1810 1820 1830 1840 1850
NGNVRPRANG DVGPLSHRQD YELQDFGPGY SDEEPDPGRD EEDLADEMIC

ITTL
Length:1,854
Mass (Da):211,464
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73DE6B07DF531A39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q01668CAC1D_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D CACH3, CACN4, CACNL1A2, CCHL1A2
2,161Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUN6A0A1B0GUN6_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
2,146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTN0A0A1B0GTN0_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
2,170Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUB6A0A1B0GUB6_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
1,647Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQ56A0A1W2PQ56_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
1,643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GWE1A0A1B0GWE1_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
1,372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTP8A0A1B0GTP8_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
490Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GW98A0A1B0GW98_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
453Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUH2A0A1B0GUH2_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4S8H7C4S8_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1D
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005905 Genomic DNA No translation available.
AC012467 Genomic DNA No translation available.
AC024149 Genomic DNA No translation available.
AC092035 Genomic DNA No translation available.
AC112218 Genomic DNA No translation available.
AC132810 Genomic DNA No translation available.
AB209171 mRNA Translation: BAD92408.1

NCBI Reference Sequences

More...
RefSeqi
NP_000711.1, NM_000720.3
NP_001122312.1, NM_001128840.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000481478.1; ENSP00000418014.1; ENSG00000157388.20

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
776

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:776

UCSC genome browser

More...
UCSCi
uc062ksr.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005905 Genomic DNA No translation available.
AC012467 Genomic DNA No translation available.
AC024149 Genomic DNA No translation available.
AC092035 Genomic DNA No translation available.
AC112218 Genomic DNA No translation available.
AC132810 Genomic DNA No translation available.
AB209171 mRNA Translation: BAD92408.1
RefSeqiNP_000711.1, NM_000720.3
NP_001122312.1, NM_001128840.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

ProteomicsDBi62658

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4062, 319 antibodies from 32 providers

The DNASU plasmid repository

More...
DNASUi
776

Genome annotation databases

EnsembliENST00000481478.1; ENSP00000418014.1; ENSG00000157388.20
GeneIDi776
KEGGihsa:776
UCSCiuc062ksr.1, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
776
HGNCiHGNC:1391, CACNA1D
OpenTargetsiENSG00000157388
PharmGKBiPA84
VEuPathDBiHostDB:ENSG00000157388

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00940000154839
OrthoDBi172471at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
776, 14 hits in 1077 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CACNA1D, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
776

Gene expression databases

BgeeiENSG00000157388, Expressed in middle temporal gyrus and 171 other tissues

Family and domain databases

Gene3Di1.20.120.350, 3 hits
InterProiView protein in InterPro
IPR031688, CAC1F_C
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR005452, LVDCC_a1dsu
IPR014873, VDCC_a1su_IQ
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16885, CAC1F_C, 2 hits
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01636, LVDCCALPHA1D
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59GD8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59GD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 25, 2022
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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