UniProtKB - Q59FP8 (Q59FP8_HUMAN)
Protein
Submitted name:
Neogenin
Gene
NEO1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- signaling receptor activity Source: InterPro
GO - Biological processi
- axon guidance Source: InterPro
- iron ion homeostasis Source: InterPro
- positive regulation of BMP signaling pathway Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: NeogeninImportedSubmitted name: Neogenin homolog 1 variantImported |
Gene namesi | Name:NEO1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000067141.16 |
HGNCi | HGNC:7754, NEO1 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: InterPro
- plasma membrane Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 773 – 797 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000067141, Expressed in cortical plate and 236 other tissues |
ExpressionAtlasi | Q59FP8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 102 | Ig-likeInterPro annotationAdd BLAST | 86 | |
Domaini | 137 – 231 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 | |
Domaini | 237 – 327 | Fibronectin type-IIIInterPro annotationAdd BLAST | 91 | |
Domaini | 332 – 427 | Fibronectin type-IIIInterPro annotationAdd BLAST | 96 | |
Domaini | 437 – 530 | Fibronectin type-IIIInterPro annotationAdd BLAST | 94 | |
Domaini | 536 – 632 | Fibronectin type-IIIInterPro annotationAdd BLAST | 97 | |
Domaini | 637 – 734 | Fibronectin type-IIIInterPro annotationAdd BLAST | 98 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 729 – 766 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 807 – 829 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 843 – 875 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 904 – 945 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 958 – 1050 | DisorderedSequence analysisAdd BLAST | 93 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 856 – 875 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 958 – 1020 | PolarSequence analysisAdd BLAST | 63 | |
Compositional biasi | 1031 – 1048 | Pro-richSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domainARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156684 |
HOGENOMi | CLU_004256_0_0_1 |
OrthoDBi | 217780at2759 |
Family and domain databases
CDDi | cd00063, FN3, 6 hits |
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR033024, Neogenin IPR010560, Neogenin_C |
PANTHERi | PTHR44170:SF14, PTHR44170:SF14, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 6 hits PF07679, I-set, 1 hit PF06583, Neogenin_C, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 6 hits SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 4 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 6 hits PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q59FP8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GNETIEAQAE LTVQAQPEFL KQPTNIYAHE SMDIVFECEV TGKPTPTVKW
60 70 80 90 100
VKNGDMVIPS DYFKIVKEHN LQVLGLVKSD EGFYQCIAEN DVGNAQAGAQ
110 120 130 140 150
LIILEHDVAI PTLPPTSLTS ATTDHLAPAT TGPLPSAPRD VVASLVSTRF
160 170 180 190 200
IKLTWRTPAS DPHGDNLTYS VFYTKEGIAR ERVENTSHPG EMQVTIQNLM
210 220 230 240 250
PATVYIFRVM AQNKHGSGES SAPLRVETQP EVQLPGPAPN LRAYAASPTS
260 270 280 290 300
ITVTWETPVS GNGEIQNYKL YYMEKGTDKE QDVDVSSHSY TINGLKKYTE
310 320 330 340 350
YSFRVVAYNK HGPGVSTPDV AVRTLSDVPS AAPQNLSLEV RNSKSIMIHW
360 370 380 390 400
QPPAPATQNG QITGYKIRYR KASRKSDVTE TLVSGTQLSQ LIEGLDRGTE
410 420 430 440 450
YNFRVAALTI NGTGPATDWL SAETFESDLD ETRVPEVPSS LHVRPLVTSI
460 470 480 490 500
VVSWTPPENQ NIVVRGYAIG YGIGSPHAQT IKVDYKQRYY TIENLDPSSH
510 520 530 540 550
YVITLKAFNN VGEGIPLYES AVTRPHTVPD PTPMMPPVGV QASILSHDTI
560 570 580 590 600
RITWADNSLP KHQKITDSRY YTVRWKTNIP ANTKYKNANA TTLSYLVTGL
610 620 630 640 650
KPNTLYEFSV MVTKGRRSST WSMTAHGTTF ELVPTSPPKD VTVVSKEGKP
660 670 680 690 700
KTIIVNWQPP SEANGKITGY IIYYSTDVNA EIHDWVIEPV VGNRLTHQIQ
710 720 730 740 750
ELTLDTPYYF KIQARNSKGM GPMSEAVQFR TPKASGSGGK GSRLPDLGSD
760 770 780 790 800
YKPPMSGSNS PHGSPTSPLD SNMLLVIIVS VGVITIVVVV IIAVFCTRRT
810 820 830 840 850
TSHQKKKRAA CKSVNGSHKY KGNSKDVKPP DLWIHHERLE LKPIDKSPDP
860 870 880 890 900
NPIMTDTPIP RNSQDITPVD NSMDSNIHQR RNSYRGHESE DSMSTLAGRR
910 920 930 940 950
GMRPKMMMPF DSQPPQPVIS AHPIHSLDNP HHHFHSSSLA SPARSHLYHP
960 970 980 990 1000
GSPWPIGTSM SLSDRANSTE SVRNTPSTDT MPASSSQTCC TDHQDPEGAT
1010 1020 1030 1040 1050
SSSYLASSQE EDSGQSLPTA HVRPSHPLKS FAVPAIPPPG PPTYDPALPS
1060 1070 1080 1090 1100
TPLLSQQALN HHIHSVKTAS IGTLGRSRPP MPVVVPSAPE VQETTRMLED
1110 1120 1130
SESSYEPDEL TKEMAHLEGL MKDLNAITTA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ92859 | NEO1_HUMAN | Neogenin | NEO1 IGDCC2, NGN | 1,461 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068397 Genomic DNA No translation available. AC104420 Genomic DNA No translation available. AC129980 Genomic DNA No translation available. AB209412 mRNA Translation: BAD92649.1 |
RefSeqi | NP_001166094.1, NM_001172623.1 NP_001166095.1, NM_001172624.1 NP_002490.2, NM_002499.3 |
Genome annotation databases
Ensembli | ENST00000560328; ENSP00000454024; ENSG00000067141 |
GeneIDi | 4756 |
KEGGi | hsa:4756 |
UCSCi | uc059ldr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068397 Genomic DNA No translation available. AC104420 Genomic DNA No translation available. AC129980 Genomic DNA No translation available. AB209412 mRNA Translation: BAD92649.1 |
RefSeqi | NP_001166094.1, NM_001172623.1 NP_001166095.1, NM_001172624.1 NP_002490.2, NM_002499.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | Q59FP8 |
PRIDEi | Q59FP8 |
ProteomicsDBi | 62652 |
Protocols and materials databases
Antibodypediai | 3989, 186 antibodies |
Genome annotation databases
Ensembli | ENST00000560328; ENSP00000454024; ENSG00000067141 |
GeneIDi | 4756 |
KEGGi | hsa:4756 |
UCSCi | uc059ldr.1, human |
Organism-specific databases
CTDi | 4756 |
EuPathDBi | HostDB:ENSG00000067141.16 |
HGNCi | HGNC:7754, NEO1 |
OpenTargetsi | ENSG00000067141 |
PharmGKBi | PA31555 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156684 |
HOGENOMi | CLU_004256_0_0_1 |
OrthoDBi | 217780at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4756, 7 hits in 846 CRISPR screens |
ChiTaRSi | NEO1, human |
GenomeRNAii | 4756 |
Gene expression databases
Bgeei | ENSG00000067141, Expressed in cortical plate and 236 other tissues |
ExpressionAtlasi | Q59FP8, baseline and differential |
Family and domain databases
CDDi | cd00063, FN3, 6 hits |
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR033024, Neogenin IPR010560, Neogenin_C |
PANTHERi | PTHR44170:SF14, PTHR44170:SF14, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 6 hits PF07679, I-set, 1 hit PF06583, Neogenin_C, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 6 hits SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 4 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 6 hits PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q59FP8_HUMAN | |
Accessioni | Q59FP8Primary (citable) accession number: Q59FP8 Secondary accession number(s): H0YNI3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |