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Entry version 122 (31 Jul 2019)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

Spectrin, beta, erythrocytic (Includes spherocytosis, clinical type I) variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Spectrin, beta, erythrocytic (Includes spherocytosis, clinical type I) variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36103

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q59FP5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q59FP5

PeptideAtlas

More...
PeptideAtlasi
Q59FP5

PRoteomics IDEntifications database

More...
PRIDEi
Q59FP5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62651

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q59FP5 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 162Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini177 – 282Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini2182 – 2292PHInterPro annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni2078 – 2182DisorderedSequence analysisAdd BLAST105
Regioni2306 – 2332DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili117 – 137Sequence analysisAdd BLAST21
Coiled coili461 – 502Sequence analysisAdd BLAST42
Coiled coili789 – 809Sequence analysisAdd BLAST21
Coiled coili994 – 1028Sequence analysisAdd BLAST35
Coiled coili1418 – 1438Sequence analysisAdd BLAST21
Coiled coili1542 – 1569Sequence analysisAdd BLAST28
Coiled coili1981 – 2005Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2078 – 2095PolyampholyteSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0517 Eukaryota
COG5069 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007281

Database of Orthologous Groups

More...
OrthoDBi
543832at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q59FP5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF15410 PH_9, 1 hit
PF00435 Spectrin, 17 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002297 Spectrin_beta_subunit, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00683 SPECTRINPH

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59FP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EPADMTSATE FENVGNQPPY SRINARWDAP DDELDNDNSS ARLFERSRIK
60 70 80 90 100
ALADEREVVQ KKTFTKWVNS HLARVSCRIT DLYKDLRDGR MLIKLLEVLS
110 120 130 140 150
GEMLPKPTKG KMRIHCLENV DKALQFLKEQ RVHLENMGSH DIVDGNHRLV
160 170 180 190 200
LGLIWTIILR FQIQDIVVQT QEGRETRSAK DALLLWCQMK TAGYPHVNVT
210 220 230 240 250
NFTSSWKDGL AFNALIHKHR PDLIDFDKLK DSNARHNLEH AFNVAERQLG
260 270 280 290 300
IIPLLDPEDV FTENPDEKSI ITYVVAFYHY FSKMKVLAVE GKRVGKVIDH
310 320 330 340 350
AIETEKMIEK YSGLASDLLT WIEQTITVLN SRKFANSLTG VQQQLQAFST
360 370 380 390 400
YRTVEKPPKF QEKGNLEVLL FTIQSRMRAN NQKVYTPHDG KLVSDINRAW
410 420 430 440 450
ESLEEAEYRR ELALRNELIR QEKLEQLARR FDRKAAMRET WLSENQRLVA
460 470 480 490 500
QDNFGYDLAA VEAAKKKHEA IETDTAAYEE RVRALEDLAQ ELEKENYHDQ
510 520 530 540 550
KRITARKDNI LRLWSYLQEL LQSRRQRLET TLALQKLFQD MLHSIDWMDE
560 570 580 590 600
IKAHLLSAEF GKHLLEVEDL LQKHKLMEAD IAIQGDKVKA ITAATLKFTE
610 620 630 640 650
GKGYQPCDPQ VIQDRISHLE QCFEELSNMA AGRKAQLEQS KRLWKFFWEM
660 670 680 690 700
DEAESWIKEK EQIYSSLDYG KDLTSVLILQ RKHKAFEDEL RGLDAHLEQI
710 720 730 740 750
FQEAHGMVAR KQFGHPQIEA RIKEVSAQWD QLKDLAAFCK KNLQDAENFF
760 770 780 790 800
QFQGDADDLK AWLQDAHRLL SGEDVGQDEG ATRALGKKHK DFLEELEESR
810 820 830 840 850
GVMEHLEQQA QGFPEEFRDS PDVTHRLQAL RELYQQVVAQ ADLRQQRLQE
860 870 880 890 900
ALDLYTVFGE TDACELWMGE KEKWLAEMEM PDTLEDLEVV QHRFDILDQE
910 920 930 940 950
MKTLMTQIDG VNLAANSLVE SGHPRSREVK QYQDHLNTRW QAFQTLVSER
960 970 980 990 1000
REAVDSALRV HNYCVDCEET SKWITDKTKV VESTKDLGRD LAGIIAIQRK
1010 1020 1030 1040 1050
LSGLERDVAA IQARVDALER ESQQLMDSHP EQKEDIGQRQ KHLEELWQGL
1060 1070 1080 1090 1100
QQSLQGQEDL LGEVSQLQAF LQDLDDFQAW LSITQKAVAS EDMPESLPEA
1110 1120 1130 1140 1150
EQLLQQHAGI KDEIDGHQDS YQRVKESGEK VIQGQTDPEY LLLGQRLEGL
1160 1170 1180 1190 1200
DTGWNALGRM WESRSHTLAQ CLGFQEFQKD AKQAEAILSN QEYTLAHLEP
1210 1220 1230 1240 1250
PDSLEAAEAG IRKFEDFLGS MENNRDKVLS PVDSGNKLVA EGNLYSDKIK
1260 1270 1280 1290 1300
EKVQLIEDRH RKNNEKAQEA SVLLRDNLEL QNFLQNCQEL TLWINDKLLT
1310 1320 1330 1340 1350
SQDVSYDEAR NLHNKWLKHQ AFVAELASHE GWLENIDAEG KQLMDEKPQF
1360 1370 1380 1390 1400
TALVSQKLEA LHRLWDELQA TTKEKTQHLS AARSSDLRLQ THADLNKWIS
1410 1420 1430 1440 1450
AMEDQLRSDD PGKDLTSVNR MLAKLKRVED QVNVRKEELG ELFAQVPSMG
1460 1470 1480 1490 1500
EEGGDADLSI EKRFLDLLEP LGRRKKQLES SRAKLQISRD LEDETLWVEE
1510 1520 1530 1540 1550
RLPLAQSADY GTNLQTVQLF MKKNQTLQNE ILGHTPRVED VLQRGQQLVE
1560 1570 1580 1590 1600
AAEIDCQDLE ERLGHLQSSW DRLREAAAGR LQRLRDANEA QQYYLDADEA
1610 1620 1630 1640 1650
EAWIGEQELY VISDEIPKDE EGAIVMLKRH LRQQRAVEDY GRNIKQLASR
1660 1670 1680 1690 1700
AQGLLSAGHP EGEQIIRLQG QVDKHYAGLK DVAEERKRKL ENMYHLFQLK
1710 1720 1730 1740 1750
RETDDLEQWI SEKELVASSP EMGQDFDHVT LLRDKFRDFA RETGAIGQER
1760 1770 1780 1790 1800
VDNVNAFIER LIDAGHSEAA TIAEWKDGLN EMWADLLELI DTRMQLLAAS
1810 1820 1830 1840 1850
YDLHRYFYTG AEILGLIDEK HRELPEDVGL DASTAESFHR VHTAFERELH
1860 1870 1880 1890 1900
LLGVQVQQFQ DVATRLQTAY AGEKAEAIQN KEQEVSAAWQ ALLDACAGRR
1910 1920 1930 1940 1950
TQLVDTADKF RFFSMARDLL SWMESIIRQI ETQERPRDVS SVELLMKYHQ
1960 1970 1980 1990 2000
GINAEIETRS KNFSACLELG ESLLQRQHQA SEEIREKLQQ VMSRRKEMNE
2010 2020 2030 2040 2050
KWEARWERLR MLLEVCQFSR DASVAEAWLI AQEPYLASGD FGHTVDSVEK
2060 2070 2080 2090 2100
LIKRHEAFEK STASWAERFA ALEKPTTLEL KERQIAERPA EETGPQEEEG
2110 2120 2130 2140 2150
ETAGEAPVSH HAATERTSPG EEEGTWPQNL QQPPPPGQHK DGQKSTGDER
2160 2170 2180 2190 2200
PTTEPLFKVL DTPLSEGDEP ATLPAPRDHG QSVQMEGYLG RKHDLEGPNK
2210 2220 2230 2240 2250
KASNRSWNNL YCVLRNSELT FYKDAKNLAL GMPYHGEEPL ALRHAICEIA
2260 2270 2280 2290 2300
ANYKKKKHVF KLRLSNGSEW LFHGKDEEEM LSWLQGVSTA INESQSIRVK
2310 2320 2330
AQSLPLPSLS GPDASLGKKD KEKRFSFFPK KK
Length:2,332
Mass (Da):268,239
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF133F5E5BBBEB8AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB209415 mRNA Translation: BAD92652.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209415 mRNA Translation: BAD92652.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiQ59FP5
MaxQBiQ59FP5
PeptideAtlasiQ59FP5
PRIDEiQ59FP5
ProteomicsDBi62651

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

PharmGKBiPA36103

Phylogenomic databases

eggNOGiKOG0517 Eukaryota
COG5069 LUCA
HOGENOMiHOG000007281
OrthoDBi543832at2759
PhylomeDBiQ59FP5

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6710

Gene expression databases

GenevisibleiQ59FP5 HS

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF15410 PH_9, 1 hit
PF00435 Spectrin, 17 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59FP5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59FP5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 31, 2019
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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