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UniProtKB - Q59FI5 (Q59FI5_HUMAN)
Protein
Protein kinase C
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 279 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- calcium-dependent protein kinase C activity Source: UniProtKB-EC
GO - Biological processi
- platelet activation Source: UniProt
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
PTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | Q59FI5 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 62 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 51 | |
Domaini | 69 – 186 | C2InterPro annotationAdd BLAST | 118 | |
Domaini | 250 – 461 | Protein kinaseInterPro annotationAdd BLAST | 212 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.ARBA annotation
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR046349, C1-like_sf IPR000008, C2_dom IPR035892, C2_domain_sf IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00168, C2, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR00360, C2DOMAIN PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00239, C2, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF56112, SSF56112, 1 hit SSF57889, SSF57889, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q59FI5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
DPTHSPKDPR SKHKFKIHTY GSPTFCDHCG SLLYGLIHQG MKCDTCDMNV
60 70 80 90 100
HKQCVINVPS LCGMDHTEKR GRIYLKAEVA DEKLHVTVRD AKNLIPMDPN
110 120 130 140 150
GLSDPYVKLK LIPDPKNESK QKTKTIRSTL NPQWNESFTF KLKPSDKDRR
160 170 180 190 200
LSVEIWDWDR TTRNDFMGSL SFGVSELMKM PASGWYKLLN QEEGEYYNVP
210 220 230 240 250
IPEGDEEGNM ELRQKFEKAK LGPAGNKVIS PSEDRKQPSN NLDRVKLTDF
260 270 280 290 300
NFLMVLGKGS FGKVMLADRK GTEELYAIKI LKKDVVIQDD DVECTMVEKR
310 320 330 340 350
VLALLDKPPF LTQLHSCFQT VDRLYFVMEY VNGGDLMYHI QQVGKFKEPQ
360 370 380 390 400
AVFYVAEISI GLFFLHKRGI IYRDLKLDNV MLDSEGHIKI ADFGMCKEHM
410 420 430 440 450
MDGVTTRTFC GTPDYIAPEI IAYQPYGKSV DWWAYGVLLY EMLAGQVMFC
460
YIFMFVYCCV M
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209475 mRNA Translation: BAD92712.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209475 mRNA Translation: BAD92712.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q59FI5 |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR046349, C1-like_sf IPR000008, C2_dom IPR035892, C2_domain_sf IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00168, C2, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR00360, C2DOMAIN PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00239, C2, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF56112, SSF56112, 1 hit SSF57889, SSF57889, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q59FI5_HUMAN | |
Accessioni | Q59FI5Primary (citable) accession number: Q59FI5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | May 25, 2022 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |