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Entry version 118 (12 Aug 2020)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

Low density lipoprotein-related protein 1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorARBA annotation
Biological processEndocytosisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Low density lipoprotein-related protein 1 variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2239 – 2259HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi348 ↔ 366PROSITE-ProRule annotation
Disulfide bondi382 ↔ 394PROSITE-ProRule annotation
Disulfide bondi389 ↔ 407PROSITE-ProRule annotation
Disulfide bondi401 ↔ 416PROSITE-ProRule annotation
Disulfide bondi421 ↔ 433PROSITE-ProRule annotation
Disulfide bondi428 ↔ 446PROSITE-ProRule annotation
Disulfide bondi440 ↔ 455PROSITE-ProRule annotation
Disulfide bondi489 ↔ 504PROSITE-ProRule annotation
Disulfide bondi512 ↔ 524PROSITE-ProRule annotation
Disulfide bondi519 ↔ 537PROSITE-ProRule annotation
Disulfide bondi531 ↔ 546PROSITE-ProRule annotation
Disulfide bondi550 ↔ 562PROSITE-ProRule annotation
Disulfide bondi557 ↔ 575PROSITE-ProRule annotation
Disulfide bondi634 ↔ 646PROSITE-ProRule annotation
Disulfide bondi641 ↔ 659PROSITE-ProRule annotation
Disulfide bondi674 ↔ 686PROSITE-ProRule annotation
Disulfide bondi728 ↔ 746PROSITE-ProRule annotation
Disulfide bondi740 ↔ 755PROSITE-ProRule annotation
Disulfide bondi802 ↔ 812PROSITE-ProRule annotation
Disulfide bondi1150 ↔ 1162PROSITE-ProRule annotation
Disulfide bondi1157 ↔ 1175PROSITE-ProRule annotation
Disulfide bondi1190 ↔ 1202PROSITE-ProRule annotation
Disulfide bondi1197 ↔ 1215PROSITE-ProRule annotation
Disulfide bondi1209 ↔ 1224PROSITE-ProRule annotation
Disulfide bondi1249 ↔ 1264PROSITE-ProRule annotation
Disulfide bondi1352 ↔ 1364PROSITE-ProRule annotation
Disulfide bondi1359 ↔ 1377PROSITE-ProRule annotation
Disulfide bondi1371 ↔ 1386PROSITE-ProRule annotation
Disulfide bondi1391 ↔ 1403PROSITE-ProRule annotation
Disulfide bondi1398 ↔ 1416PROSITE-ProRule annotation
Disulfide bondi1410 ↔ 1425PROSITE-ProRule annotation
Disulfide bondi1429 ↔ 1441PROSITE-ProRule annotation
Disulfide bondi1436 ↔ 1454PROSITE-ProRule annotation
Disulfide bondi1448 ↔ 1463PROSITE-ProRule annotation
Disulfide bondi1470 ↔ 1482PROSITE-ProRule annotation
Disulfide bondi1477 ↔ 1495PROSITE-ProRule annotation
Disulfide bondi1532 ↔ 1547PROSITE-ProRule annotation
Disulfide bondi1576 ↔ 1591PROSITE-ProRule annotation
Disulfide bondi2015 ↔ 2025PROSITE-ProRule annotation
Disulfide bondi2051 ↔ 2061PROSITE-ProRule annotation
Disulfide bondi2073 ↔ 2082PROSITE-ProRule annotation
Disulfide bondi2087 ↔ 2097PROSITE-ProRule annotation
Disulfide bondi2123 ↔ 2133PROSITE-ProRule annotation
Disulfide bondi2145 ↔ 2154PROSITE-ProRule annotation
Disulfide bondi2192 ↔ 2202PROSITE-ProRule annotation
Disulfide bondi2214 ↔ 2223PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation, LipoproteinImported

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q59FG2

PRoteomics IDEntifications database

More...
PRIDEi
Q59FG2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q59FG2, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati69 – 110LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati111 – 159LDL-receptor class BPROSITE-ProRule annotationAdd BLAST49
Repeati160 – 204LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati205 – 247LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati248 – 289LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini798 – 833EGF-likeInterPro annotationAdd BLAST36
Repeati885 – 929LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati930 – 972LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati973 – 1016LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1017 – 1059LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1060 – 1100LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati1727 – 1739LDL-receptor class BPROSITE-ProRule annotationAdd BLAST13
Repeati1785 – 1827LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1828 – 1871LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1872 – 1916LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Domaini2011 – 2044EGF-likeInterPro annotationAdd BLAST34
Domaini2047 – 2083EGF-likeInterPro annotationAdd BLAST37
Domaini2084 – 2116EGF-likeInterPro annotationAdd BLAST33
Domaini2119 – 2155EGF-likeInterPro annotationAdd BLAST37
Domaini2190 – 2224EGF-likeInterPro annotationAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.ARBA annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K04550

Database of Orthologous Groups

More...
OrthoDBi
1606at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 21 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 3 hits
4.10.400.10, 21 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR032485, DUF5050
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 1 hit
PF16472, DUF5050, 1 hit
PF07645, EGF_CA, 1 hit
PF00057, Ldl_recept_a, 19 hits
PF00058, Ldl_recept_b, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 17 hits
SM00179, EGF_CA, 5 hits
SM00192, LDLa, 21 hits
SM00135, LY, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 1 hit
SSF57424, SSF57424, 20 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 1 hit
PS01209, LDLRA_1, 8 hits
PS50068, LDLRA_2, 21 hits
PS51120, LDLRB, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59FG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VCFVCLSHLL PPDSVYLLYS ERTILKSIHL SDERNLNAPV QPFEDPEHMK
60 70 80 90 100
NVIALAFDYR AGTSPGTPNR IFFSDIHFGN IQQINDDGSR RITIVENVGS
110 120 130 140 150
VEGLAYHRGW DTLYWTSYTT STITRHTVDQ TRPGAFERET VITMSGDDHP
160 170 180 190 200
RAFVLDECQN LMFWTNWNEQ HPSIMRAALS GANVLTLIEK DIRTPNGLAI
210 220 230 240 250
DHRAEKLYFS DATLDKIERC EYDGSHRYVI LKSEPVHPFG LAVYGEHIFW
260 270 280 290 300
TDWVRRAVQR ANKHVGSNMK LLRVDIPQQP MGIIAVANDT NSCELSPCRI
310 320 330 340 350
NNGGCQDLCL LTHQGHVNCS CRGGRILQDD LTCRAVNSSC RAQDEFECAN
360 370 380 390 400
GECINFSLTC DGVPHCKDKS DEKPSYCNSR RCKKTFRQCS NGRCVSNMLW
410 420 430 440 450
CNGADDCGDG SDEIPCNKTA CGVGEFRCRD GTCIGNSSRC NQFVDCEDAS
460 470 480 490 500
DEMNCSATDC SSYFRLGVKG VLFQPCERTS LCYAPSWVCD GANDCGDYSD
510 520 530 540 550
ERDCPGVKRP RCPLNYFACP SGRCIPMSWT CDKEDDCEHG EDETHCNKFC
560 570 580 590 600
SEAQFECQNH RCISKQWLCD GSDDCGDGSD EAAHCEGKTC GPSSFSCPGT
610 620 630 640 650
HVCVPERWLC DGDKDCADGA DESIAAGCLY NSTCDDREFM CQNRQCIPKH
660 670 680 690 700
FVCDHDRDCA DGSDESPECE YPTCGPSEFR CANGRCLSSR QWECDGENDC
710 720 730 740 750
HDQSDEAPKN PHCTSPEHKC NASSQFLCSS GRCVAEALLC NGQDDCGDSS
760 770 780 790 800
DERGCHINEC LSRKLSGCSQ DCEDLKIGFK CRCRPGFRLK DDGRTCADVD
810 820 830 840 850
ECSTTFPCSQ RCINTHGSYK CLCVEGYAPR GGDPHSCKAV TDEEPFLIFA
860 870 880 890 900
NRYYLRKLNL DGSNYTLLKQ GLNNAVALDF DYREQMIYWT DVTTQGSMIR
910 920 930 940 950
RMHLNGSNVQ VLHRTGLSNP DGLAVDWVGG NLYWCDKGRD TIEVSKLNGA
960 970 980 990 1000
YRTVLVSSGL REPRALVVDV QNGYLYWTDW GDHSLIGRIG MDGSSRSVIV
1010 1020 1030 1040 1050
DTKITWPNGL TLDYVTERIY WADAREDYIE FASLDGSNRH VVLSQDIPHI
1060 1070 1080 1090 1100
FALTLFEDYV YWTDWETKSI NRAHKTTGTN KTLLISTLHR PMDLHVFHAL
1110 1120 1130 1140 1150
RQPDVPNHPC KVNNGGCSNL CLLSPGGGHK CACPTNFYLG SDGRTCVSNC
1160 1170 1180 1190 1200
TASQFVCKND KCIPFWWKCD TEDDCGDHSD EPPDCPEFKC RPGQFQCSTG
1210 1220 1230 1240 1250
ICTNPAFICD GDNDCQDNSD EANCDIHVCL PSQFKCTNTN RCIPGIFRCN
1260 1270 1280 1290 1300
GQDNCGDGED ERDCPEVTCA PNQFQCSITK RCIPRVWVCD RDNDCVDGSD
1310 1320 1330 1340 1350
EPANCTQMTC GVDEFRCKDS GRCIPARWKC DGEDDCGDGS DEPKEECDER
1360 1370 1380 1390 1400
TCEPYQFRCK NNRCVPGRWQ CDYDNDCGDN SDEESCTPRP CSESEFSCAN
1410 1420 1430 1440 1450
GRCIAGRWKC DGDHDCADGS DEKDCTPRCD MDQFQCKSGH CIPLRWRCDA
1460 1470 1480 1490 1500
DADCMDGSDE EACGTGVRTC PLDEFQCNNT LCKPLAWKCD GEDDCGDNSD
1510 1520 1530 1540 1550
ENPEECARFV CPPNRPFRCK NDRVCLWIGR QCDGTDNCGD GTDEEDCEPP
1560 1570 1580 1590 1600
TAHTTHCKDK KEFLCRNQRC LSSLRCNMFD DCGDGSDEED CSIDPKLTSC
1610 1620 1630 1640 1650
ATNASICGDE ARCVRTEKAA YCACRSGFHT VPGQPGCQDI NECLRFGTCS
1660 1670 1680 1690 1700
QLCNNTKGGH LCSCARNFMK THNTCKAEGS EYQVLYIADD NEIRSLFPGH
1710 1720 1730 1740 1750
PHSAYEQAFQ GDESVRIDAM DVHVKAGRVY WTNWHTGTIS YRSLPPAAPP
1760 1770 1780 1790 1800
TTSNRHRRQI DRGVTHLNIS GLKMPRGIAI DWVAGNVYWT DSGRDVIEVA
1810 1820 1830 1840 1850
QMKGENRKTL ISGMIDEPHA IVVDPLRGTM YWSDWGNHPK IETAAMDGTL
1860 1870 1880 1890 1900
RETLVQDNIQ WPTGLAVDYH NERLYWADAK LSVIGSIRLN GTDPIVAADS
1910 1920 1930 1940 1950
KRGLSHPFSI DVFEDYIYGV TYINNRVFKI HKFGHSPLVN LTGGLSHASD
1960 1970 1980 1990 2000
VVLYHQHKQP EVTNPCDRKK CEWLCLLSPS GPVCTCPNGK RLDNGTCVPV
2010 2020 2030 2040 2050
PSPTPPPDAP RPGTCNLQCF NGGSCFLNAR RQPKCRCQPR YTGDKCELDQ
2060 2070 2080 2090 2100
CWEHCRNGGT CAASPSGMPT CRCPTGFTGP KCTQQVCAGY CANNSTCTVN
2110 2120 2130 2140 2150
QGNQPQCRCL PGFLGDRCQY RQCSGYCENF GTCQMAADGS RQCRCTAYFE
2160 2170 2180 2190 2200
GSRCEVNKCS RCLEGACVVN KQSGDVTCNC TDGRVAPSCL TCVGHCSNGG
2210 2220 2230 2240 2250
SCTMNSKMMP ECQCPPHMTG PRCEEHVFSQ QQPGHIASIL IPLLLLLLLV
2260 2270 2280 2290 2300
LVAGVVFWYK RRVQGAKGFQ HQRMTNGAMN VEIGNPTYKM YEGGEPDDVG
2310 2320 2330 2340 2350
GLLDADFALD PDKPTNFTNP VYATLYMGGH GSRHSLASTD EKRELLGRGP

EDEIGDPLA
Length:2,359
Mass (Da):262,019
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2588B2908EA320B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB209498 mRNA Translation: BAD92735.1

NCBI Reference Sequences

More...
RefSeqi
NP_002323.2, NM_002332.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4035

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4035

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209498 mRNA Translation: BAD92735.1
RefSeqiNP_002323.2, NM_002332.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ59FG2
PRIDEiQ59FG2

Genome annotation databases

GeneIDi4035
KEGGihsa:4035

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4035

Phylogenomic databases

KOiK04550
OrthoDBi1606at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4035, 5 hits in 876 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4035

Gene expression databases

GenevisibleiQ59FG2, HS

Family and domain databases

CDDicd00112, LDLa, 21 hits
Gene3Di2.120.10.30, 3 hits
4.10.400.10, 21 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR032485, DUF5050
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF16472, DUF5050, 1 hit
PF07645, EGF_CA, 1 hit
PF00057, Ldl_recept_a, 19 hits
PF00058, Ldl_recept_b, 5 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 17 hits
SM00179, EGF_CA, 5 hits
SM00192, LDLa, 21 hits
SM00135, LY, 13 hits
SUPFAMiSSF57184, SSF57184, 1 hit
SSF57424, SSF57424, 20 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 1 hit
PS01209, LDLRA_1, 8 hits
PS50068, LDLRA_2, 21 hits
PS51120, LDLRB, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59FG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59FG2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: August 12, 2020
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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