UniProtKB - Q59FD9 (Q59FD9_HUMAN)
Protein
Submitted name:
Actinin, alpha 2 variant
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calcium ion binding Source: InterPro
Keywordsi
Molecular function | Actin-bindingARBA annotation |
Ligand | CalciumARBA annotation, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Actinin, alpha 2 variantImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 523 – 558 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 559 – 594 | EF-handInterPro annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 42 – 69 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 159 – 179 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 207 – 241 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 263 – 290 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 441 – 475 | Sequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotationFamily and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR014837, EF-hand_Ca_insen IPR002048, EF_hand_dom IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF08726, EFhand_Ca_insen, 1 hit PF00435, Spectrin, 4 hits |
SMARTi | View protein in SMART SM00054, EFh, 2 hits SM00150, SPEC, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits |
i Sequence
Sequence statusi: Fragment.
Q59FD9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
STLSSVEGSP PESSTCSYQE MRRSSVNSSA MAETAANRIC KVLAVNQENE
60 70 80 90 100
RLMEEYERLA SELLEWIRRT IPWLENRTPE KTMQAMQKKL EDFRDYRRKH
110 120 130 140 150
KPPKVQEKCQ LEINFNTLQT KLRISNRPAF MPSEGKMVSD IAGAWQRLEQ
160 170 180 190 200
AEKGYEEWLL NEIRRLERLE HLAEKFRQKA STHETWAYGK EQILLQKDYE
210 220 230 240 250
SASLTEVRAL LRKHEAFESD LAAHQDRVEQ IAAIAQELNE LDYHDAVNVN
260 270 280 290 300
DRCQKICDQW DRLGTLTQKR REALERMEKL LETIDQLHLE FAKRAAPFNN
310 320 330 340 350
WMEGAMEDLQ DMFIVHSIEE IQSLITAHEQ FKATLPEADG ERQSIMAIQN
360 370 380 390 400
EVEKVIQSYN IRISSSNPYS TVTMDELRTK WDKVKQLVPI RDQSLQEELA
410 420 430 440 450
RQHANERLRR QFAAQANAIG PWIQNKMEEI ARSSIQITGA LEDQMNQLKQ
460 470 480 490 500
YEHNIINYKN NIDKLEGDHQ LIQEALVFDN KHTNYTMEHI RVGWELLLTT
510 520 530 540 550
IARTINEVET QILTRDAKGI TQEQMNEFRA SFNHFDRRKN GLMDHEDFRA
560 570 580 590 600
CLISMGYDLG EAEFARIMTL VDPNGQGTVT FQSFIDFMTR ETADTDTAEQ
610 620 630 640 650
VIASFRILAS DKPYILAEEL RRELPPDQAQ YCIKRMPAYS GPGSVPGALD
660
YAAFSSALYG ESDL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209521 mRNA Translation: BAD92758.1 |
RefSeqi | NP_001265273.1, NM_001278344.1 |
Genome annotation databases
GeneIDi | 88 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209521 mRNA Translation: BAD92758.1 |
RefSeqi | NP_001265273.1, NM_001278344.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q59FD9 |
Protocols and materials databases
DNASUi | 88 |
Genome annotation databases
GeneIDi | 88 |
Organism-specific databases
CTDi | 88 |
Miscellaneous databases
BioGRID-ORCSi | 88, 10 hits in 986 CRISPR screens |
GenomeRNAii | 88 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR014837, EF-hand_Ca_insen IPR002048, EF_hand_dom IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF08726, EFhand_Ca_insen, 1 hit PF00435, Spectrin, 4 hits |
SMARTi | View protein in SMART SM00054, EFh, 2 hits SM00150, SPEC, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q59FD9_HUMAN | |
Accessioni | Q59FD9Primary (citable) accession number: Q59FD9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | April 7, 2021 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |