UniProtKB - Q59FA0 (Q59FA0_HUMAN)
Protein
DNA polymerase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.7.7UniRule annotation
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA-directed DNA polymerase activity Source: UniProtKB-KW
- nucleotide binding Source: InterPro
GO - Biological processi
- DNA replication Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotationARBA annotation, Nucleotidyltransferase, Transferase |
Biological process | DNA replicationUniRule annotation |
Ligand | 4Fe-4SARBA annotation, Iron, Iron-sulfur, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 479 | DNA_pol_B_exo1InterPro annotationAdd BLAST | 347 | |
Domaini | 543 – 909 | DNA_pol_BInterPro annotationAdd BLAST | 367 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 35 | DisorderedSequence analysisAdd BLAST | 35 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 43 – 63 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerARBA annotationFamily and domain databases
Gene3Di | 1.10.132.60, 1 hit 3.30.420.10, 1 hit 3.90.1600.10, 1 hit |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR017964, DNA-dir_DNA_pol_B_CS IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR043502, DNA/RNA_pol_sf IPR042087, DNA_pol_B_C IPR023211, DNA_pol_palm_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 1 hit PF03104, DNA_pol_B_exo1, 1 hit |
PRINTSi | PR00106, DNAPOLB |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00116, DNA_POLYMERASE_B, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q59FA0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SGMDGKRRPG PGPGVPPKRA RGGLWDDDDA PWPSQFEEDL ALMEEMEAEH
60 70 80 90 100
RLQEQEEEEL QSVLEGVADG QVPPSAIDPR WLRPTPPALD PQTEPLIFQQ
110 120 130 140 150
LEIDHYVGPA QPVPGGPPPS RGSVPVLRAF GVTDEGFSVC CHIHGFAPYF
160 170 180 190 200
YTPAPPGFGP EHMGDLQREL NLAISRDSRG GRELTGPAVL AVELCSRESM
210 220 230 240 250
FGYHGHGPSP FLRITVALPR LVAPARRLLE QGIRVAGLGT PSFAPYEANV
260 270 280 290 300
DFEIRFMVDT DIVGCNWLEL PAGKYALRLK EKATQCQLEA DVLWSDVVSH
310 320 330 340 350
PPEGPWQRIA PLRVLSFDIE CAGRKGIFPE PERDPVIQIC SLGLRWGEPE
360 370 380 390 400
PFLRLALTLR PCAPILGAKV QSYEKEEDLL QAWSTFIRIM DPDVITGYNI
410 420 430 440 450
QNFDLPYLIS RAQTLKVQTF PFLGRVAGLC SNIRDSSFQS KQTGRRDTKV
460 470 480 490 500
VSMVGRVQMD MLQVLLREYK LRSYTLNAVS FHFLGEQKED VQHSIITDLQ
510 520 530 540 550
NGNDQTRRRL AVYCLKDAYL PLRLLERLMV LVNAVEMARV TGVPLSYLLS
560 570 580 590 600
RGQQVKVVSQ LLRQAMHEGL LMPVVKSEGG EDYTGATVIE PLKGYYDVPI
610 620 630 640 650
ATLDFSSLYP SIMMAHNLCY TTLLRPGTAQ KLGLTEDQFI RTPTGDEFVK
660 670 680 690 700
TSVRKGLLPQ ILENLLSARK RAKAELAKET DPLRRQVLDG RQLALKVSAN
710 720 730 740 750
SVYGFTGAQV GKLPCLEISQ SVTGFGRQMI EKTKQLVESK YTVENGYSTS
760 770 780 790 800
AKVVYGDTDS VMCRFGVSSV AEAMALGREA ADWVSGHFPS PIRLEFEKVY
810 820 830 840 850
FPYLLISKKR YAGLLFSSRP DAHDRMDCKG LEAVRRDNCP LVANLVTASL
860 870 880 890 900
RRLLIDRDPE GAVAHAQDVI SDLLCNRIDI SQLVITKELT RAASDYAGKQ
910 920 930 940 950
AHVELAERTR CSCWSTACPL TRSTTWSSSW PSPSCASSSP SWARAVPRLC
960 970 980 990 1000
YCGGTTRAAR RCSRARWAAS WPSPNAATAA LAAAQCSATR EPCVSSASPG
1010
SLSCIRRRYP I
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209560 mRNA Translation: BAD92797.1 |
RefSeqi | NP_002682.2, NM_002691.3 |
Genome annotation databases
GeneIDi | 5424 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209560 mRNA Translation: BAD92797.1 |
RefSeqi | NP_002682.2, NM_002691.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | Q59FA0 |
PeptideAtlasi | Q59FA0 |
Genome annotation databases
GeneIDi | 5424 |
Organism-specific databases
CTDi | 5424 |
Miscellaneous databases
BioGRID-ORCSi | 5424, 739 hits in 851 CRISPR screens |
GenomeRNAii | 5424 |
Family and domain databases
Gene3Di | 1.10.132.60, 1 hit 3.30.420.10, 1 hit 3.90.1600.10, 1 hit |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR017964, DNA-dir_DNA_pol_B_CS IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR043502, DNA/RNA_pol_sf IPR042087, DNA_pol_B_C IPR023211, DNA_pol_palm_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 1 hit PF03104, DNA_pol_B_exo1, 1 hit |
PRINTSi | PR00106, DNAPOLB |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00116, DNA_POLYMERASE_B, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q59FA0_HUMAN | |
Accessioni | Q59FA0Primary (citable) accession number: Q59FA0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |