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UniProtKB - Q59F16 (Q59F16_HUMAN)

Entry version 73 (02 Dec 2020)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

Alpha 1 type VII collagen variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alpha 1 type VII collagen variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26730

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		Q59F16

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q59F16, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 580DisorderedSequence analysisAdd BLAST580
Regioni602 – 1027DisorderedSequence analysisAdd BLAST426

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 31Pro-richSequence analysisAdd BLAST24
Compositional biasi64 – 78Pro-richSequence analysisAdd BLAST15
Compositional biasi352 – 369PolyampholyteSequence analysisAdd BLAST18
Compositional biasi487 – 514PolyampholyteSequence analysisAdd BLAST28
Compositional biasi524 – 540Pro-richSequence analysisAdd BLAST17
Compositional biasi695 – 712PolyampholyteSequence analysisAdd BLAST18
Compositional biasi718 – 735Pro-richSequence analysisAdd BLAST18
Compositional biasi808 – 834Pro-richSequence analysisAdd BLAST27
Compositional biasi917 – 931Pro-richSequence analysisAdd BLAST15
Compositional biasi973 – 989PolyampholyteSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

CollagenImported

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		67372at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008160, Collagen

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01391, Collagen, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59F16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GLPGRKGDPG PSGPPGPRGP LGDPGPRGPP GLPGTAMKGD KGDRGERGPP 
        60         70         80         90        100
GPGEGGIAPG EPGLPGLPGS PGPQGPVGPP GKKGEKGDSE DGAPGLPGQP 
       110        120        130        140        150
GSPGEQGPRG PPGAIGPKGD RGFPGPLGEA GEKGERGPPG PAGSRGLPGV 
       160        170        180        190        200
AGRPGAKGPE GPPGPTGRQG EKGEPGRPGD PAVVGPAVAG PKGEKGDVGP 
       210        220        230        240        250
AGPRGATGVQ GERGPPGLVL PGDPGPKGDP GDRGPIGLTG RAGPPGDSGP 
       260        270        280        290        300
PGEKGDPGRP GPPGPVGPRG RDGEVGEKGD EGPPGDPGLP GKAGERGLRG 
       310        320        330        340        350
APGVRGPVGE KGDQGDPGED GRNGSPGSSG PKGDRGEPGP PGPPGRLVDT 
       360        370        380        390        400
GPGAREKGEP GDRGQEGPRG PKGDPGLPGA PGERGIEGFR GPPGPQGDPG 
       410        420        430        440        450
VRGPAGEKGD RGPPGLDGRS GLDGKPGAAG PSGPNGAAGK AGDPGRDGLP 
       460        470        480        490        500
GLRGEQGLPG PSGPPGLPGK PGEDGKPGLN GKNGEPGDPG EDGRKGEKGD 
       510        520        530        540        550
SGASGREGRD GPKGERGAPG ILGPQGPPGL PGPVGPPGQG FPGVPGGTGP 
       560        570        580        590        600
KGDRGETGSK GEQGLPGERG LRGEPGSVPN VDRLLETAGI KASALREIVE 
       610        620        630        640        650
TWDESSGSFL PVPERRRGPK GDSGEQGPPG KEGPIGFPGE RGLKGDRGDP 
       660        670        680        690        700
GPQGPPGLAL GERGPPGPSG LAGEPGKPGI PGLPGRAGGV GEAGRPGERG 
       710        720        730        740        750
ERGEKGERGE QGRDGPPGLP GTPGPPGPPG PKVSVDEPGP GLSGEQGPPG 
       760        770        780        790        800
LKGAKGEPGS NGDQGPKGDR GVPGIKGDRG EPGPRGQDGN PGLPGERGMA 
       810        820        830        840        850
GPEGKPGLQG PRGPPGPVGG HGDPGPPGAP GLAGPAGPQG PSGLKGEPGE 
       860        870        880        890        900
TGPPGRGLTG PTGAVGLPGP PGPSGLVGPQ GSPGLPGQVG ETGKPGAPGR 
       910        920        930        940        950
DGASGKDGDR GSPGVPGSPG LPGPVGPKGE PGPTGAPGQA VVGLPGAKGE 
       960        970        980        990       1000
KGAPGGLAGD LVGEPGAKGD RGLPGPRGEK GEAGRAGEPG DPGEDVSPGP 
      1010       1020 
RQGRAWPEEC DGGHKGPLLG RGTCLSP
Length:1,027
Mass (Da):96,806
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59F1A5256985A6D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB209645 mRNA Translation: BAD92882.1

NCBI Reference Sequences

More...RefSeqi		NP_000085.1, NM_000094.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1294

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1294

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209645 mRNA Translation: BAD92882.1
RefSeqiNP_000085.1, NM_000094.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ59F16

Genome annotation databases

GeneIDi1294
KEGGihsa:1294

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1294
PharmGKBiPA26730

Phylogenomic databases

OrthoDBi67372at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1294, 12 hits in 842 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1294

Gene expression databases

GenevisibleiQ59F16, HS

Family and domain databases

InterProiView protein in InterPro
IPR008160, Collagen
PfamiView protein in Pfam
PF01391, Collagen, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59F16_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59F16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: December 2, 2020
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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