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Entry version 84 (12 Aug 2020)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

Insulin-like growth factor 2 receptor variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Insulin-like growth factor 2 receptor variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2228 – 2250HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q59EZ3

PRoteomics IDEntifications database

More...
PRIDEi
Q59EZ3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1821 – 1867Fibronectin type-IIInterPro annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2347 – 2414DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2365 – 2387PolyampholyteSequence analysisAdd BLAST23

Keywords - Domaini

SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00062, FN2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
2.70.130.10, 15 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000479, CIMR_rpt
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013806, Kringle-like
IPR009011, Man6P_isomerase_rcpt-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00878, CIMR, 14 hits
PF00040, fn2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00059, FN2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57440, SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59EZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GPSSAVCMHD LKTRTYHSVG DSVLRSATRS LLEFNTTVSC DQQGTNHRVQ
60 70 80 90 100
SSIAFLCGKT LGTPEFVTAT ECVHYFEWRT TAACKKDIFK ANKEVPCYVF
110 120 130 140 150
DEELRKHDLN PLIKLSGAYL VDDSDPDTSL FINVCRDIDT LRDPGSQLRA
160 170 180 190 200
CPPGTAACLV RGHQAFDVGQ PRDGLKLVRK DRLVLSYVRE EAGKLDFCDG
210 220 230 240 250
HSPAVTITFV CPSERREGTI PKLTAKSNCR YEIEWITEYA CHRDYLESKT
260 270 280 290 300
CSLSGEQQDV SIDLTPLAQS GGSSYISDGK EYLFYLNVCG ETEIQFCNKK
310 320 330 340 350
QAAVCQVKKS DTSQVKAAGR YHNQTLRYSD GDLTLIYFGG DECSSGFQRM
360 370 380 390 400
SVINFECNKT AGNDGKGTPV FTGEVDCTYF FTWDTEYACV KEKEDLLCGA
410 420 430 440 450
TDGKKRYDLS ALVRHAEPEQ NWEAVDGSQT ETEKKHFFIN ICHRVLQEGK
460 470 480 490 500
ARGCPEDAAV CAVDKNGSKN LGKFISSPMK EKGNIQLSYS DGDDCGHGKK
510 520 530 540 550
IKTNITLVCK PGDLESAPVL RTSGEGGCFY EFEWHTAAAC VLSKTEGENC
560 570 580 590 600
TVFDSQAGFS FDLSPLTKKN GAYKVETKKY DFYINVCGPV SVSPCQPDSG
610 620 630 640 650
ACQVAKSDEK TWNLGLSNAK LSYYDGMIQL NYRGGTPYNN ERHTPRATLI
660 670 680 690 700
TFLCDRDAGV GFPEYQEEDN STYNFRWYTS YACPEEPLEC VVTDPSTLEQ
710 720 730 740 750
YDLSSLAKSE GGLGGNWYAM DNSGEHVTWR KYYINVCRPL NPVPGCNRYA
760 770 780 790 800
SACQMKYEKD QGSFTEVVSI SNLGMAKTGP VVEDSGSLLL EYVNGSACTT
810 820 830 840 850
SDGRQTTYTT RIHLVCSRGR LNSHPIFSLN WECVVSFLWN TEAACPIQTT
860 870 880 890 900
TDTDQACSIR DPNSGFVFNL NPLNSSQGYN VSGIGKIFMF NVCGTMPVCG
910 920 930 940 950
TILGKPASGC EAETQTEELK NWKPARPVGI EKSLQLSTEG FITLTYKGPL
960 970 980 990 1000
SAKGTADAFI VRFVCNDDVY SGPLKFLHQD IDSGQGIRNT YFEFETALAC
1010 1020 1030 1040 1050
VPSPVDCQVT DLAGNEYDLT GLSTVRKPWT AVDTSVDGRK RTFYLSVCNP
1060 1070 1080 1090 1100
LPYIPGCQGS AVGSCLVSEG NSWNLGVVQM SPQAAANGSL SIMYVNGDKC
1110 1120 1130 1140 1150
GNQRFSTRIT FECAQISGSP AFQLQDGCEY VFIWRTVEAC PVVRVEGDNC
1160 1170 1180 1190 1200
EVKDPRHGNL YDLKPLGLND TIVSAGEYTY YFRVCGKLSS DVCPTSDKSK
1210 1220 1230 1240 1250
VVSSCQEKRE PQGFHKVAGL LTQKLTYENG LLKMNFTGGD TCHKVYQRST
1260 1270 1280 1290 1300
AIFFYCDRGT QRPVFLKETS DCSYLFEWRT QYACPPFDLT ECSFKDGAGN
1310 1320 1330 1340 1350
SFDLSSLSRY SDNWEAITGT GDPEHYLINV CKSLAPQAGT EPCPPEAAAC
1360 1370 1380 1390 1400
LLGGSKPVNL GRVRDGPQWR DGIIVLKYVD GDLCPDGIRK KSTTIRFTCS
1410 1420 1430 1440 1450
ESQVNSRPMF ISAVEDCEYT FAWPTATACP MKSNEHDDCQ VTNPSTGHLF
1460 1470 1480 1490 1500
DLSSLSGRAG FTAAYSEKGL VYMSICGENE NCPPGVGACF GQTRISVGKA
1510 1520 1530 1540 1550
NKRLRYVDQV LQLVYKDGSP CPSKSGLSYK SVISFVCRPE AGPTNRPMLI
1560 1570 1580 1590 1600
SLDKQTCTLF FSWHTPLACE QATECSVRNG SSIVDLSPLI HRTGGYEAYD
1610 1620 1630 1640 1650
ESEDDASDTN PDFYINICQP LNPMHGVPCP AGAAVCKVPI DGPPIDIGRV
1660 1670 1680 1690 1700
AGPPILNPIA NEIYLNFESS TPCLADKHFN YTSLIAFHCK RGVSMGTPKL
1710 1720 1730 1740 1750
LRTSECDFVF EWETPVVCPD EVRMDGCTLT DEQLLYSFNL SSLSTSTFKV
1760 1770 1780 1790 1800
TRDSRTYSVG VCTFAVGPEQ GGCKDGGVCL LSGTKGASFG RLQSMKLDYR
1810 1820 1830 1840 1850
HQDEAVVLSY VNGDRCPPET DDGVPCVFPF IFNGKSYEEC IIESRAKLWC
1860 1870 1880 1890 1900
STTADYDRDH EWGFCRHSNS YRTSSIIFKC DEDEDIGRPQ VFSEVRGCDV
1910 1920 1930 1940 1950
TFEWKTKVVC PPKKLECKFV QKHKTYDLRL LSSLTGSWSL VHNGVSYYIN
1960 1970 1980 1990 2000
LCQKIYKGPL GCSERASICR RTTTGDVQVL GLVHTQKLGV IGDKVVVTYS
2010 2020 2030 2040 2050
KGYPCGGNKT ASSVIELTPT KTVGRPAFKR FDIDSCTYYF SWDSRAACAV
2060 2070 2080 2090 2100
KPQEVQMVNG TITNPINGKS FSLGDIYFKL FRASGDMRTN GDNYLYEIQL
2110 2120 2130 2140 2150
SSITSSRNPA CSGANICQVK PNDQHFSRKV GTSDKTKYYL QDGDLDVVFA
2160 2170 2180 2190 2200
SSSKCGKDKT KSVSSTIFFH CDPLVEDGIP EFSHETADCQ YLFSWYTSAV
2210 2220 2230 2240 2250
CPLGVGFDSE NPGDDGQMHK GLSERSQAVG AVLSLLLVAL TCCLLALLLY
2260 2270 2280 2290 2300
KKERRETVIS KLTTCCRRSS NVSYKYSKVN KEEETDENET EWLMEEIQLP
2310 2320 2330 2340 2350
PPRQGKEGQE NGHITTKSVK ALSSLHGDDQ DSEDEVLTIP EVKVHSGRGA
2360 2370 2380 2390 2400
GAESSHPVRN AQSNALQERE DDRVGLVRGE KARKGKSSSA QQKTVSSTKL
2410
VSFHDDSDED LLHI
Length:2,414
Mass (Da):266,114
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB330B247A541AFB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB209668 mRNA Translation: BAD92905.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209668 mRNA Translation: BAD92905.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ59EZ3
PRIDEiQ59EZ3

Family and domain databases

CDDicd00062, FN2, 1 hit
Gene3Di2.10.10.10, 1 hit
2.70.130.10, 15 hits
InterProiView protein in InterPro
IPR000479, CIMR_rpt
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013806, Kringle-like
IPR009011, Man6P_isomerase_rcpt-bd_dom_sf
PfamiView protein in Pfam
PF00878, CIMR, 14 hits
PF00040, fn2, 1 hit
SMARTiView protein in SMART
SM00059, FN2, 1 hit
SUPFAMiSSF57440, SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59EZ3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59EZ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: August 12, 2020
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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