UniProtKB - Q59EW6 (Q59EW6_HUMAN)
Protein
Glutamate receptor
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.UniRule annotation
GO - Molecular functioni
- ionotropic glutamate receptor activity Source: InterPro
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channelUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptorUniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 584 – 606 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 656 – 678 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 847 – 870 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
Cell junction, Cell membraneUniRule annotationARBA annotation, Membrane, Postsynaptic cell membraneUniRule annotationARBA annotation, SynapseFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 458 – 825 | PBPeInterPro annotationAdd BLAST | 368 | |
Domaini | 466 – 529 | Lig_chan-Glu_bdInterPro annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1016 – 1110 | DisorderedSequence analysisAdd BLAST | 95 | |
Regioni | 1362 – 1399 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1016 – 1035 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1046 – 1063 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1064 – 1110 | PolyampholyteSequence analysisAdd BLAST | 47 | |
Compositional biasi | 1380 – 1399 | PolyampholyteSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]UniRule annotation
Keywords - Domaini
SignalARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
OMAi | PKYPRDC |
OrthoDBi | 188544at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR018884, NMDAR2_C IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit PF10565, NMDAR2_C, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q59EW6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GGRDARARSA PHCILDLLGL QGPSVATMGR VGYWTLLVLP ALLVWRGPAP
60 70 80 90 100
SAAAEKGPPA LNIAVMLGHS HDVTERELRT LWGPEQAAGL PLDVNVVALL
110 120 130 140 150
MNRTDPKSLI THVCDLMSGA RIHGLVFGDD TDQEAVAQML DFISSHTFVP
160 170 180 190 200
ILGIHGGASM IMADKDPTST FFQFGASIQQ QATVMLKIMQ DYDWHVFSLV
210 220 230 240 250
TTIFPGYREF ISFVKTTVDN SFVGWDMQNV ITLDTSFEDA KTQVQLKKIH
260 270 280 290 300
SSVILLYCSK DEAVLILSEA RSLGLTGYDF FWIVPSLVSG NTELIPKEFP
310 320 330 340 350
SGLISVSYDD WDYSLEARVR DGIGILTTAA SSMLEKFSYI PEAKASCYGQ
360 370 380 390 400
MERPEVPMHT LHPFMVNVTW DGKDLSFTEE GYQVHPRLVV IVLNKDREWE
410 420 430 440 450
KVGKWENHTL SLRHAVWPRY KSFSDCEPDD NHLSIVTLEE APFVIVEDID
460 470 480 490 500
PLTETCVRNT VPCRKFVKIN NSTNEGMNVK KCCKGFCIDI LKKLSRTVKF
510 520 530 540 550
TYDLYLVTNG KHGKKVNNVW NGMIGEVVYQ RAVMAVGSLT INEERSEVVD
560 570 580 590 600
FSVPFVETGI SVMVSRSNGT VSPSAFLEPF SASVWVMMFV MLLIVSAIAV
610 620 630 640 650
FVFEYFSPVG YNRNLAKGKA PHGPSFTIGK AIWLLWGLVF NNSVPVQNPK
660 670 680 690 700
GTTSKIMVSV WAFFAVIFLA SYTANLAAFM IQEEFVDQVT GLSDKKFQRP
710 720 730 740 750
HDYSPPFRFG TVPNGSTERN IRNNYPYMHQ YMTKFNQKGV EDALVSLKTG
760 770 780 790 800
KLDAFIYDAA VLNYKAGRDE GCKLVTIGSG YIFATTGYGI ALQKGSPWKR
810 820 830 840 850
QIDLALLQFV GDGEMEELET LWLTGICHNE KNEVMSSQLD IDNMAGVFYM
860 870 880 890 900
LAAAMALSLI TFIWEHLFYW KLRFCFTGVC SDRPGLLFSI SRGIYSCIHG
910 920 930 940 950
VHIEEKKKSP DFNLTGSQSN MLKLLRSAKN ISSMSNMNSS RMDSPKRAAD
960 970 980 990 1000
FIQRGSLIMD MVSDKGNLMY SDNRSFQGKE SIFGDNMNEL QTFVANRQKD
1010 1020 1030 1040 1050
NLNNYVFQGQ HPLTLNESNP NTVEVAVSTE SKANSRPRQL WKKSVDSIRQ
1060 1070 1080 1090 1100
DSLSQNPVSQ RDEATAENRT HSLKSPRYLP EEMAHSDFSE TSNRATCHRE
1110 1120 1130 1140 1150
PDNSKNHKTK DNFKRSVASK YPKDCSEVER TYLKTKSSSP RDKIYTIDGE
1160 1170 1180 1190 1200
KEPGFHLDPP QFVENVTLPE NVDFPDPYQD PSENFRKGDS TLPMNRNPLH
1210 1220 1230 1240 1250
NEEGLSNNDQ YKLYSKHFTL KDKGSPHSET SERYRQNSTH CRSCLSNMPT
1260 1270 1280 1290 1300
YSGHFTMRSP FKCDACLRMG NLYDIDEDQM LQETGNPATG EQVYQQDWAQ
1310 1320 1330 1340 1350
NNALQLQKNK LRISRQHSYD NIVDKPRELD LSRPSRSISL KDRERLLEGN
1360 1370 1380 1390 1400
FYGSLFSVPS SKLSGKKSSL FPQGLEDSKR SKSLLPDHTS DNPFLHSHRD
1410 1420 1430 1440 1450
DQRLVIGRCP SDPYKHSLPS QAVNDSYLRS SLRSTASYCS RDSRGHNDVY
1460 1470 1480 1490
ISEHVMPYAA NKNNMYSTPR VLNSCSNRRV YKKMPSIESD V
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209695 mRNA Translation: BAD92932.1 |
RefSeqi | NP_001127879.1, NM_001134407.2 |
Genome annotation databases
GeneIDi | 2903 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209695 mRNA Translation: BAD92932.1 |
RefSeqi | NP_001127879.1, NM_001134407.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q59EW6 |
Protocols and materials databases
DNASUi | 2903 |
Genome annotation databases
GeneIDi | 2903 |
Organism-specific databases
CTDi | 2903 |
PharmGKBi | PA28979 |
Phylogenomic databases
OMAi | PKYPRDC |
OrthoDBi | 188544at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2903, 3 hits in 988 CRISPR screens |
GenomeRNAii | 2903 |
Gene expression databases
Genevisiblei | Q59EW6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR018884, NMDAR2_C IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit PF10565, NMDAR2_C, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q59EW6_HUMAN | |
Accessioni | Q59EW6Primary (citable) accession number: Q59EW6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | April 7, 2021 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |