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UniProtKB - Q59EV6 (Q59EV6_HUMAN)

Entry version 100 (19 Jan 2022)
Sequence version 1 (26 Apr 2005)
Previous versions | rss
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Protein

Carboxypeptidase

Gene

PPGB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, Protease

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-CTSA, Carboxypeptidase_S10

MEROPS protease database

More...MEROPSi		S10.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CarboxypeptidaseUniRule annotation (EC:3.4.16.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPGBImported
ORF Names:hCG_38374Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 45Sequence analysisAdd BLAST45
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501013988346 – 497CarboxypeptidaseSequence analysisAdd BLAST452

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q59EV6
With#Exp.IntAct
AHNAK2 - isoform 3 [Q8IVF2-3]3EBI-14210385,EBI-12078468
AQP2 [P41181]3EBI-14210385,EBI-12701138
AQP6 [Q13520]3EBI-14210385,EBI-13059134
ARL13B [Q3SXY8]3EBI-14210385,EBI-11343438
ASPH - isoform 6 [Q12797-6]3EBI-14210385,EBI-12092171
BSND [Q8WZ55]3EBI-14210385,EBI-7996695
CD79A [P11912]3EBI-14210385,EBI-7797864
COQ9 [O75208]3EBI-14210385,EBI-724524
CPLX4 [Q7Z7G2]3EBI-14210385,EBI-18013275
CREB3L1 [Q96BA8]3EBI-14210385,EBI-6942903
CSPG5 - isoform 2 [O95196-2]3EBI-14210385,EBI-18400097
ERGIC3 [Q9Y282]3EBI-14210385,EBI-781551
FAM209A [Q5JX71]3EBI-14210385,EBI-18304435
FKBP7 [Q9Y680]3EBI-14210385,EBI-3918971
FNDC9 [Q8TBE3]3EBI-14210385,EBI-12142257
GORAB [Q5T7V8]3EBI-14210385,EBI-3917143
HIBADH [P31937]3EBI-14210385,EBI-11427100
HTT [P42858]10EBI-14210385,EBI-466029
MFSD14B [Q5SR56]3EBI-14210385,EBI-373355
MGST3 [O14880]3EBI-14210385,EBI-724754
MUC1 - isoform Y-LSP [P15941-11]3EBI-14210385,EBI-17263240
MYG1 [Q9HB07]3EBI-14210385,EBI-709754
REEP4 [Q9H6H4]3EBI-14210385,EBI-7545592
RHBDD1 [Q8TEB9]3EBI-14210385,EBI-9916444
RNF122 [Q9H9V4]3EBI-14210385,EBI-2129998
SAR1A [Q9NR31]3EBI-14210385,EBI-3920694
SGMS2 [Q8NHU3]3EBI-14210385,EBI-10977284
SIGLEC12 [Q96PQ1]3EBI-14210385,EBI-17640454
SLC18A1 - isoform 3 [P54219-3]3EBI-14210385,EBI-17595455
SLC30A2 [Q9BRI3]3EBI-14210385,EBI-8644112
SPN [P16150]3EBI-14210385,EBI-10049055
SSMEM1 [Q8WWF3]3EBI-14210385,EBI-17280858
STX2 - isoform 1 [P32856-2]3EBI-14210385,EBI-11956649
THAP4 [Q8WY91]3EBI-14210385,EBI-726691
TMEM139 [Q8IV31]3EBI-14210385,EBI-7238458
TMEM154 [Q6P9G4]3EBI-14210385,EBI-13329239
TMEM237 - isoform 2 [Q96Q45-2]5EBI-14210385,EBI-10982110
TMEM35A [Q53FP2]3EBI-14210385,EBI-11722971
TMX2 [Q9Y320]3EBI-14210385,EBI-6447886

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q59EV6, 40 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S10 family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR001563, Peptidase_S10
IPR033124, Ser_caboxypep_his_AS
IPR018202, Ser_caboxypep_ser_AS

The PANTHER Classification System

More...PANTHERi		PTHR11802, PTHR11802, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00450, Peptidase_S10, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00724, CRBOXYPTASEC

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00560, CARBOXYPEPT_SER_HIS, 1 hit
PS00131, CARBOXYPEPT_SER_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59EV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSPRAPPG EQGRGGAEMI RAAPPPLFLL LLLLLLVSWA SRGEAAPDQD 
        60         70         80         90        100
EIQRLPGLAK QPSFRQYSGY LKGSGSKHLH YWFVESQKDP ENSPVVLWLN 
       110        120        130        140        150
GGPGCSSLDG LLTEHGPFLV QPDGVTLEYN PYSWNLIANV LYLESPAGVG 
       160        170        180        190        200
FSYSDDKFYA TNDTEVAQSN FEALQDFFRL FPEYKNNKLF LTGESYAGIY 
       210        220        230        240        250
IPTLAVLVMQ DPSMNLQGLA VGNGLSSYEQ NDNSLVYFAY YHGLLGNRLW 
       260        270        280        290        300
SSLQTHCCSQ NKCNFYDNKD LECVTNLQEV ARIVGNSGLN IYNLYAPCAG 
       310        320        330        340        350
GVPSHFRYEK DTVVVQDLGN IFTRLPLKRM WHQALLRSGD KVRMDPPCTN 
       360        370        380        390        400
TTAASTYLNN PYVRKALNIP EQLPQWDMCN FLVNLQYRRL YRSMNSQYLK 
       410        420        430        440        450
LLSSQKYQIL LYNGDVDMAC NFMGDEWFVD SLNQKMEVQR RPWLVKYGDS 
       460        470        480        490 
GEQIAGFVKE FSHIAFLTIK GAGHMVPTDK PLAAFTMFSR FLNKQPY
Length:497
Mass (Da):56,120
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE54B23F0EFF02E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB209705 mRNA Translation: BAD92942.1
CH471077 Genomic DNA Translation: EAW75789.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209705 mRNA Translation: BAD92942.1
CH471077 Genomic DNA Translation: EAW75789.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ59EV6, 40 interactors

Protein family/group databases

ESTHERihuman-CTSA, Carboxypeptidase_S10
MEROPSiS10.002

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CTSA, human

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR001563, Peptidase_S10
IPR033124, Ser_caboxypep_his_AS
IPR018202, Ser_caboxypep_ser_AS
PANTHERiPTHR11802, PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450, Peptidase_S10, 1 hit
PRINTSiPR00724, CRBOXYPTASEC
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560, CARBOXYPEPT_SER_HIS, 1 hit
PS00131, CARBOXYPEPT_SER_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59EV6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59EV6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: January 19, 2022
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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