UniProtKB - Q59EN6 (Q59EN6_HUMAN)
Protein
Sphingomyelin phosphodiesterase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.1.4.12ARBA annotation
Cofactori
Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 241 | Zinc 1UniRule annotation | 1 | |
Metal bindingi | 243 | Zinc 1; via tele nitrogenUniRule annotation | 1 | |
Metal bindingi | 313 | Zinc 1UniRule annotation | 1 | |
Metal bindingi | 313 | Zinc 2UniRule annotation | 1 | |
Metal bindingi | 353 | Zinc 2UniRule annotation | 1 | |
Metal bindingi | 460 | Zinc 2; via tele nitrogenUniRule annotation | 1 | |
Metal bindingi | 492 | Zinc 2; via pros nitrogenUniRule annotation | 1 | |
Metal bindingi | 494 | Zinc 1; via tele nitrogenUniRule annotation | 1 |
GO - Molecular functioni
- hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- sphingomyelin phosphodiesterase activity Source: UniProtKB-EC
GO - Biological processi
- sphingomyelin catabolic process Source: InterPro
Keywordsi
Molecular function | GlycosidaseARBA annotation, Hydrolase |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 63 – 82 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Membrane, SecretedARBA annotationPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 124 ↔ 200 | UniRule annotation | ||
Disulfide bondi | 127 ↔ 192 | UniRule annotation | ||
Disulfide bondi | 155 ↔ 166 | UniRule annotation | ||
Disulfide bondi | 256 ↔ 261 | UniRule annotation | ||
Disulfide bondi | 262 ↔ 285 | UniRule annotation | ||
Disulfide bondi | 420 ↔ 466 | UniRule annotation | ||
Disulfide bondi | 619 ↔ 623 | UniRule annotation | ||
Disulfide bondi | 629 ↔ 642 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 120 – 204 | Saposin B-typeInterPro annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 34 | DisorderedSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the acid sphingomyelinase family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OrthoDBi | 1142100at2759 |
Family and domain databases
CDDi | cd00842, MPP_ASMase, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR041805, ASMase/PPN1_MPP IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR011001, Saposin-like IPR008139, SaposinB_dom IPR011160, Sphingomy_PDE |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
PIRSFi | PIRSF000948, Sphingomy_PDE, 1 hit |
SMARTi | View protein in SMART SM00741, SapB, 1 hit |
SUPFAMi | SSF47862, SSF47862, 1 hit |
PROSITEi | View protein in PROSITE PS50015, SAP_B, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q59EN6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SGVPGAARGP EGWLGSRPGG TGQTNQPRVG SATMPRYGAS LRQSCPRSGR
60 70 80 90 100
EQGQDGTAGA PGLLWMGLAL ALALALALAL ALSDSRVLWA PAEAHPLSPQ
110 120 130 140 150
GHPARLHRIV PRLRDVFGWG NLTCPICKGL FTAINLGLKK EPNVARVGSV
160 170 180 190 200
AIKLCNLLKI APPAVCQSIV HLFEDDMVEV WRRSVLSPSE ACGLLLGSTC
210 220 230 240 250
GHWDIFSSWN ISLPTVPKPP PKPPSPPAPG APVSRILFLT DLHWDHDYLE
260 270 280 290 300
GTDPDCADPL CCRRGSGLPP ASRPGAGYWG EYSKCDLPLR TLESLLSGLG
310 320 330 340 350
PAGPFDMVYW TGDIPAHDVW HQTRQDQLRA LTTVTALVRK FLGPVPVYPA
360 370 380 390 400
VGNHESTPVN SFPPPFIEGN HSSRWLYEAM AKAWEPWLPA EALRTLRIGG
410 420 430 440 450
FYALSPYPGL RLISLNMNFC SRENFWLLIN STDPAGQLQW LVGELQAAED
460 470 480 490 500
RGDKVHIIGH IPPGHCLKSW SWNYYRIVAR YENTLAAQFF GHTHVDEFEV
510 520 530 540 550
FYDEETLSRP LAVAFLAPSA TTYIGLNPGY RVYQIDGNYS GSSHVVLDHE
560 570 580 590 600
TYILNLTQAN IPGAIPHWQL LYRARETYGL PNTLPTAWHN LVYRMRGDMQ
610 620 630 640 650
LFQTFWFLYH KGHPPSEPCG TPCRLATLCA QLSARADSPA LCRHLMPDGS
660
LPEAQSLWPR PLFC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209775 mRNA Translation: BAD93012.1 |
RefSeqi | NP_000534.3, NM_000543.4 NP_001007594.2, NM_001007593.2 NP_001305017.1, NM_001318088.1 |
Genome annotation databases
GeneIDi | 6609 |
KEGGi | hsa:6609 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209775 mRNA Translation: BAD93012.1 |
RefSeqi | NP_000534.3, NM_000543.4 NP_001007594.2, NM_001007593.2 NP_001305017.1, NM_001318088.1 |
3D structure databases
SMRi | Q59EN6 |
ModBasei | Search... |
Protocols and materials databases
DNASUi | 6609 |
Genome annotation databases
GeneIDi | 6609 |
KEGGi | hsa:6609 |
Organism-specific databases
CTDi | 6609 |
Phylogenomic databases
OrthoDBi | 1142100at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6609, 5 hits in 849 CRISPR screens |
GenomeRNAii | 6609 |
Gene expression databases
Genevisiblei | Q59EN6, HS |
Family and domain databases
CDDi | cd00842, MPP_ASMase, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR041805, ASMase/PPN1_MPP IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR011001, Saposin-like IPR008139, SaposinB_dom IPR011160, Sphingomy_PDE |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
PIRSFi | PIRSF000948, Sphingomy_PDE, 1 hit |
SMARTi | View protein in SMART SM00741, SapB, 1 hit |
SUPFAMi | SSF47862, SSF47862, 1 hit |
PROSITEi | View protein in PROSITE PS50015, SAP_B, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q59EN6_HUMAN | |
Accessioni | Q59EN6Primary (citable) accession number: Q59EN6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | December 2, 2020 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |