UniProtKB - Q59EL5 (Q59EL5_HUMAN)
Protein
Submitted name:
Aldo-keto reductase family 1, member B1 variant
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 46 | Proton donorUniRule annotation | 1 | |
Sitei | 75 | Lowers pKa of active site TyrUniRule annotation | 1 | |
Binding sitei | 108 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- oxidoreductase activity Source: UniProtKB-KW
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Ligand | NADPARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Aldo-keto reductase family 1, member B1 variantImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 245 | Aldo_ket_redInterPro annotationAdd BLAST | 233 |
Sequence similaritiesi
Belongs to the aldo/keto reductase family.ARBA annotation
Family and domain databases
CDDi | cd06660, Aldo_ket_red, 1 hit |
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR018170, Aldo/ket_reductase_CS IPR020471, Aldo/keto_reductase IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
PANTHERi | PTHR11732, PTHR11732, 1 hit |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PIRSFi | PIRSF000097, AKR, 1 hit |
PRINTSi | PR00069, ALDKETRDTASE |
SUPFAMi | SSF51430, SSF51430, 1 hit |
PROSITEi | View protein in PROSITE PS00798, ALDOKETO_REDUCTASE_1, 1 hit PS00062, ALDOKETO_REDUCTASE_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q59EL5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
RLLLNNGAKM PILGLGTWKS PPGQVTEAVK VAIDVGYRHI DCAHVYQNEN
60 70 80 90 100
EVGVAIQEKL REQVVKREEL FIVSKLWCTY HEKGLVKGAC QKTLSDLKLD
110 120 130 140 150
YLDLYLIHWP TGFKPGKEFF PLDESGNVVP SDTNILDTWA AMEELVDEGL
160 170 180 190 200
VKAIGISNFN HLQVEMILNK PGLKYKPAVN QIECHPYLTQ EKLIQYCQSK
210 220 230 240 250
GIVVTAYSPL GSPDRPWAKP EDPSLLEDPR IKAIAAKHNK TTAQVQPLQV
260
LLTVHNCLHS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209796 mRNA Translation: BAD93033.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209796 mRNA Translation: BAD93033.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q59EL5 |
Family and domain databases
CDDi | cd06660, Aldo_ket_red, 1 hit |
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR018170, Aldo/ket_reductase_CS IPR020471, Aldo/keto_reductase IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
PANTHERi | PTHR11732, PTHR11732, 1 hit |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PIRSFi | PIRSF000097, AKR, 1 hit |
PRINTSi | PR00069, ALDKETRDTASE |
SUPFAMi | SSF51430, SSF51430, 1 hit |
PROSITEi | View protein in PROSITE PS00798, ALDOKETO_REDUCTASE_1, 1 hit PS00062, ALDOKETO_REDUCTASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q59EL5_HUMAN | |
Accessioni | Q59EL5Primary (citable) accession number: Q59EL5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | October 7, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |