UniProtKB - Q59EL2 (Q59EL2_HUMAN)
Protein
COP9 signalosome complex subunit 2
Gene
N/A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: COP9 signalosome complex subunit 2ARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- COP9 signalosome Source: InterPro
Other locations
- cytoplasm Source: UniProtKB-SubCell
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 262 – 424 | PCIInterPro annotationAdd BLAST | 163 |
Sequence similaritiesi
Belongs to the CSN2 family.ARBA annotation
Phylogenomic databases
OrthoDBi | 1108845at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR037750, COPS2 IPR000717, PCI_dom IPR011990, TPR-like_helical_dom_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10678:SF3, PTHR10678:SF3, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q59EL2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KMSDMEDDFM CDDEEDYDLE YSEDSNSEPN VDLENQYYNS KALKEDDPKA
60 70 80 90 100
ALSSFQKVLE LEGEKGEWGF KALKQMIKIN FKLTNFPEMM NRYKQLLTYI
110 120 130 140 150
RSAVTRNYSE KSINSILDYI STSKQNSDFL CQMDLLQEFY ETTLEALKDA
160 170 180 190 200
KNDRLWFKTN TKLGKLYLER EEYGKLQKIL RQLHQSCQTD DGEDDLKKGT
210 220 230 240 250
QLLEIYALEI QMYTAQKNNK KLKALYEQSL HIKSAIPHPL IMGVIRECGG
260 270 280 290 300
KMHLREGEFE KAHTDFFEAF KNYDESGSPR RTTCLKYLVL ANMLMKSGIN
310 320 330 340 350
PFDSQEAKPY KNDPEILAMT NLVSAYQNND ITEFEKILKT NHSNIMDDPF
360 370 380 390 400
IREHIEELLR NIRTQVLIKL IKPYTRIHIP FISKELNIDV ADVESLLVQC
410 420 430 440 450
ILDNTIHGRI DQVNQLLELD HQKRGGARYT ALDKWTNQLN SLNQAVVSKL
A
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209799 mRNA Translation: BAD93036.1 |
RefSeqi | NP_001137359.1, NM_001143887.1 |
Genome annotation databases
GeneIDi | 9318 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209799 mRNA Translation: BAD93036.1 |
RefSeqi | NP_001137359.1, NM_001143887.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q59EL2, 2 interactors |
MINTi | Q59EL2 |
Proteomic databases
PeptideAtlasi | Q59EL2 |
Protocols and materials databases
DNASUi | 9318 |
Genome annotation databases
GeneIDi | 9318 |
Organism-specific databases
CTDi | 9318 |
PharmGKBi | PA134952445 |
Phylogenomic databases
OrthoDBi | 1108845at2759 |
Miscellaneous databases
BioGRID-ORCSi | 9318, 671 hits in 890 CRISPR screens |
GenomeRNAii | 9318 |
Gene expression databases
Genevisiblei | Q59EL2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR037750, COPS2 IPR000717, PCI_dom IPR011990, TPR-like_helical_dom_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10678:SF3, PTHR10678:SF3, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q59EL2_HUMAN | |
Accessioni | Q59EL2Primary (citable) accession number: Q59EL2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | February 10, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |