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Protein

RUN domain-containing protein 3A

Gene

RUNDC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as an effector of RAP2A in neuronal cells.By similarity

GO - Molecular functioni

  • GTPase regulator activity Source: ProtInc

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
RUN domain-containing protein 3A
Alternative name(s):
Rap2-interacting protein 8
Short name:
RPIP-8
Gene namesi
Name:RUNDC3A
Synonyms:RAP2IP, RPIP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108309.12
HGNCiHGNC:16984 RUNDC3A
MIMi605448 gene
neXtProtiNX_Q59EK9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108309
PharmGKBiPA162402277

Polymorphism and mutation databases

BioMutaiRUNDC3A
DMDMi172045944

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241551 – 446RUN domain-containing protein 3AAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215PhosphothreonineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei416PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ59EK9
PeptideAtlasiQ59EK9
PRIDEiQ59EK9
ProteomicsDBi62634
62635 [Q59EK9-2]
62636 [Q59EK9-3]
62637 [Q59EK9-4]

PTM databases

iPTMnetiQ59EK9
PhosphoSitePlusiQ59EK9

Expressioni

Gene expression databases

BgeeiENSG00000108309 Expressed in 178 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_RUNDC3A
GenevisibleiQ59EK9 HS

Organism-specific databases

HPAiHPA023548
HPA070733

Interactioni

Subunit structurei

Interacts with the GTP-bound form of RAP2A.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi116106, 44 interactors
IntActiQ59EK9, 33 interactors
STRINGi9606.ENSP00000410862

Structurei

3D structure databases

ProteinModelPortaliQ59EK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 189RUNPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 298Interaction with RAP2ABy similarityAdd BLAST298

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili267 – 322Sequence analysisAdd BLAST56

Sequence similaritiesi

Belongs to the RUNDC3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4381 Eukaryota
ENOG410XRAX LUCA
GeneTreeiENSGT00550000074558
HOGENOMiHOG000143407
HOVERGENiHBG052747
InParanoidiQ59EK9
OMAiEESWSNK
OrthoDBiEOG091G06Y5
PhylomeDBiQ59EK9
TreeFamiTF323904

Family and domain databases

InterProiView protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
PfamiView protein in Pfam
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q59EK9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASFVQTTM ALGLSSKKAS SRNVAVERKN LITVCRFSVK TLLEKYTAEP
60 70 80 90 100
IDDSSEEFVN FAAILEQILS HRFKACAPAG PVSWFSSDGQ RGFWDYIRLA
110 120 130 140 150
CSKVPNNCVS SIENMENIST ARAKGRAWIR VALMEKRMSE YITTALRDTR
160 170 180 190 200
TTRRFYDSGA IMLRDEATIL TGMLIGLSAI DFSFCLKGEV LDGKTPVVID
210 220 230 240 250
YTPYLKFTQS YDYLTDEEER HSAESSTSED NSPEHPYLPL VTDEDSWYSK
260 270 280 290 300
WHKMEQKFRI VYAQKGYLEE LVRLRESQLK DLEAENRRLQ LQLEEAAAQN
310 320 330 340 350
QREKRELEGV ILELQEQLTG LIPSDHAPLA QGSKELTTPL VNQWPSLGTL
360 370 380 390 400
NGAEGASNSK LYRRHSFMST EPLSAEASLS SDSQRLGEGT RDEEPWGPIG
410 420 430 440
KDPTPSMLGL CGSLASIPSC KSLASFKSNE CLVSDSPEGS PALSPS
Length:446
Mass (Da):49,747
Last modified:March 18, 2008 - v2
Checksum:i2C753EA8619B1024
GO
Isoform 2 (identifier: Q59EK9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-79: Missing.
     401-405: KDPTP → SSEPN
     406-446: Missing.

Show »
Length:400
Mass (Da):45,269
Checksum:iA240F80E209EDB28
GO
Isoform 3 (identifier: Q59EK9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-405: KDPTP → SSEPN
     406-446: Missing.

Show »
Length:405
Mass (Da):45,682
Checksum:i4D39EDF3A180023A
GO
Isoform 4 (identifier: Q59EK9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-446: Missing.

Show »
Length:364
Mass (Da):41,324
Checksum:iDE4CDEBD8C6085CF
GO

Sequence cautioni

The sequence BAD93039 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134M → V in CAD97685 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03215375 – 79Missing in isoform 2. 2 Publications5
Alternative sequenceiVSP_032154365 – 446Missing in isoform 4. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_032155401 – 405KDPTP → SSEPN in isoform 2 and isoform 3. 6 Publications5
Alternative sequenceiVSP_032156406 – 446Missing in isoform 2 and isoform 3. 6 PublicationsAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93871 mRNA Translation: AAB68767.1
AF055026 mRNA Translation: AAC09366.1
AK313669 mRNA Translation: BAG36421.1
CR456748 mRNA Translation: CAG33029.1
AB209802 mRNA Translation: BAD93039.1 Different initiation.
BX537443 mRNA Translation: CAD97685.1
AL133657 mRNA Translation: CAB63771.1
CH471178 Genomic DNA Translation: EAW51609.1
CH471178 Genomic DNA Translation: EAW51610.1
BC006194 mRNA Translation: AAH06194.1
CCDSiCCDS45698.1 [Q59EK9-1]
CCDS45699.1 [Q59EK9-3]
CCDS59294.1 [Q59EK9-2]
RefSeqiNP_001138297.1, NM_001144825.1 [Q59EK9-1]
NP_001138298.1, NM_001144826.1 [Q59EK9-2]
NP_006686.1, NM_006695.4 [Q59EK9-3]
UniGeneiHs.500197

Genome annotation databases

EnsembliENST00000225441; ENSP00000225441; ENSG00000108309 [Q59EK9-3]
ENST00000426726; ENSP00000410862; ENSG00000108309 [Q59EK9-1]
ENST00000590941; ENSP00000468214; ENSG00000108309 [Q59EK9-2]
GeneIDi10900
KEGGihsa:10900
UCSCiuc002igi.4 human [Q59EK9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93871 mRNA Translation: AAB68767.1
AF055026 mRNA Translation: AAC09366.1
AK313669 mRNA Translation: BAG36421.1
CR456748 mRNA Translation: CAG33029.1
AB209802 mRNA Translation: BAD93039.1 Different initiation.
BX537443 mRNA Translation: CAD97685.1
AL133657 mRNA Translation: CAB63771.1
CH471178 Genomic DNA Translation: EAW51609.1
CH471178 Genomic DNA Translation: EAW51610.1
BC006194 mRNA Translation: AAH06194.1
CCDSiCCDS45698.1 [Q59EK9-1]
CCDS45699.1 [Q59EK9-3]
CCDS59294.1 [Q59EK9-2]
RefSeqiNP_001138297.1, NM_001144825.1 [Q59EK9-1]
NP_001138298.1, NM_001144826.1 [Q59EK9-2]
NP_006686.1, NM_006695.4 [Q59EK9-3]
UniGeneiHs.500197

3D structure databases

ProteinModelPortaliQ59EK9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116106, 44 interactors
IntActiQ59EK9, 33 interactors
STRINGi9606.ENSP00000410862

PTM databases

iPTMnetiQ59EK9
PhosphoSitePlusiQ59EK9

Polymorphism and mutation databases

BioMutaiRUNDC3A
DMDMi172045944

Proteomic databases

PaxDbiQ59EK9
PeptideAtlasiQ59EK9
PRIDEiQ59EK9
ProteomicsDBi62634
62635 [Q59EK9-2]
62636 [Q59EK9-3]
62637 [Q59EK9-4]

Protocols and materials databases

DNASUi10900
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225441; ENSP00000225441; ENSG00000108309 [Q59EK9-3]
ENST00000426726; ENSP00000410862; ENSG00000108309 [Q59EK9-1]
ENST00000590941; ENSP00000468214; ENSG00000108309 [Q59EK9-2]
GeneIDi10900
KEGGihsa:10900
UCSCiuc002igi.4 human [Q59EK9-1]

Organism-specific databases

CTDi10900
EuPathDBiHostDB:ENSG00000108309.12
GeneCardsiRUNDC3A
HGNCiHGNC:16984 RUNDC3A
HPAiHPA023548
HPA070733
MIMi605448 gene
neXtProtiNX_Q59EK9
OpenTargetsiENSG00000108309
PharmGKBiPA162402277
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4381 Eukaryota
ENOG410XRAX LUCA
GeneTreeiENSGT00550000074558
HOGENOMiHOG000143407
HOVERGENiHBG052747
InParanoidiQ59EK9
OMAiEESWSNK
OrthoDBiEOG091G06Y5
PhylomeDBiQ59EK9
TreeFamiTF323904

Miscellaneous databases

ChiTaRSiRUNDC3A human
GeneWikiiRUNDC3A
GenomeRNAii10900
PROiPR:Q59EK9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108309 Expressed in 178 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_RUNDC3A
GenevisibleiQ59EK9 HS

Family and domain databases

InterProiView protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
PfamiView protein in Pfam
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRUN3A_HUMAN
AccessioniPrimary (citable) accession number: Q59EK9
Secondary accession number(s): B2R974
, O15483, O60651, Q7Z3S2, Q9UF50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 7, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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