UniProtKB - Q59EG3 (Q59EG3_HUMAN)
Protein
Submitted name:
MutL protein homolog 1 variant
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: InterPro
- mismatched DNA binding Source: InterPro
GO - Biological processi
- mismatch repair Source: InterPro
Keywordsi
Biological process | DNA damageARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: MutL protein homolog 1 variantImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-KW
Other locations
- mismatch repair complex Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 81 – 200 | DNA_mis_repairInterPro annotationAdd BLAST | 120 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 220 – 243 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 265 – 356 | DisorderedSequence analysisAdd BLAST | 92 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 223 – 243 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 265 – 281 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 283 – 297 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 310 – 328 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 329 – 356 | PolyampholyteSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the DNA mismatch repair MutL/HexB family.ARBA annotation
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit 3.30.565.10, 1 hit |
InterProi | View protein in InterPro IPR013507, DNA_mismatch_S5_2-like IPR036890, HATPase_C_sf IPR032189, Mlh1_C IPR038973, MutL/Mlh/Pms IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr |
PANTHERi | PTHR10073, PTHR10073, 2 hits |
Pfami | View protein in Pfam PF01119, DNA_mis_repair, 1 hit PF16413, Mlh1_C, 2 hits |
SMARTi | View protein in SMART SM01340, DNA_mis_repair, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q59EG3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KPLLNHVLAI KGPRSRWRTF FYNIATRRKA LKNPSEEYGK ILEVVGRYSV
60 70 80 90 100
HNAGISFSVK KQGETVADVR TLPNASTVDN IRSIFGNAVS RELIEIGCED
110 120 130 140 150
KTLAFKMNGY ISNANYSVKK CIFLLFINHR LVESTSLRKA IETVYAAYLP
160 170 180 190 200
KNTHPFLYLS LEISPQNVDV NVHPTKHEVH FLHEESILER VQQHIESKLL
210 220 230 240 250
GSNSSRMYFT QTLLPGLAGP SGEMVKSTTS LTSSSTSGSS DKVYAHQMVR
260 270 280 290 300
TDSREQKLDA FLQPLSKPLS SQPQAIVTED KTDISSGRAR QQDEEMLELP
310 320 330 340 350
APAEVAAKNQ SLEGDTTKGT SEMSEKRGPT SSNPRKRHRE DSDVEMVEDD
360 370 380 390 400
SRKEMTAACT PRRRIINLTS VLSLQEEINE QGHEVLREML HNHSFVGCVN
410 420 430 440 450
PQWALAQHQT KLYLLNTTKL SEELFYQILI YDFANFGVLR LSEPAPLFDL
460 470 480 490 500
AMLALDSPES GWTEEDGPKE GLAEYIVEFL KKKAEMLADY FSLEIDESEV
510 520 530 540 550
PGSIPNSWKW TVEHIVYKAL RSHILPPKHF TEDGNILQLA NLPDLYKVFE
RC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209848 mRNA Translation: BAD93085.1 |
RefSeqi | NP_001245200.1, NM_001258271.1 |
Genome annotation databases
GeneIDi | 4292 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209848 mRNA Translation: BAD93085.1 |
RefSeqi | NP_001245200.1, NM_001258271.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q59EG3 |
Protocols and materials databases
DNASUi | 4292 |
Genome annotation databases
GeneIDi | 4292 |
Organism-specific databases
CTDi | 4292 |
Miscellaneous databases
BioGRID-ORCSi | 4292, 8 hits in 1002 CRISPR screens |
GenomeRNAii | 4292 |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit 3.30.565.10, 1 hit |
InterProi | View protein in InterPro IPR013507, DNA_mismatch_S5_2-like IPR036890, HATPase_C_sf IPR032189, Mlh1_C IPR038973, MutL/Mlh/Pms IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr |
PANTHERi | PTHR10073, PTHR10073, 2 hits |
Pfami | View protein in Pfam PF01119, DNA_mis_repair, 1 hit PF16413, Mlh1_C, 2 hits |
SMARTi | View protein in SMART SM01340, DNA_mis_repair, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q59EG3_HUMAN | |
Accessioni | Q59EG3Primary (citable) accession number: Q59EG3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | April 7, 2021 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |