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Entry version 117 (07 Apr 2021)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

Nuclear receptor coactivator 3 isoform a variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, ReceptorImported
Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear receptor coactivator 3 isoform a variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31472

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q59EE8, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 86BHLHInterPro annotationAdd BLAST58
Domaini121 – 184PASInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni14 – 40DisorderedSequence analysisAdd BLAST27
Regioni412 – 497DisorderedSequence analysisAdd BLAST86
Regioni505 – 524DisorderedSequence analysisAdd BLAST20
Regioni541 – 678DisorderedSequence analysisAdd BLAST138
Regioni713 – 734DisorderedSequence analysisAdd BLAST22
Regioni752 – 802DisorderedSequence analysisAdd BLAST51
Regioni915 – 949DisorderedSequence analysisAdd BLAST35
Regioni1276 – 1324DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi507 – 524PolarSequence analysisAdd BLAST18
Compositional biasi541 – 576PolarSequence analysisAdd BLAST36
Compositional biasi594 – 608PolyampholyteSequence analysisAdd BLAST15
Compositional biasi632 – 678PolarSequence analysisAdd BLAST47
Compositional biasi765 – 784PolarSequence analysisAdd BLAST20
Compositional biasi1276 – 1291PolarSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
HQFSPVT

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00130, PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.1070, 1 hit
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598, bHLH_dom
IPR010011, DUF1518
IPR032565, DUF4927
IPR036638, HLH_DNA-bd_sf
IPR028818, NCOA3
IPR009110, Nuc_rcpt_coact
IPR014920, Nuc_rcpt_coact_Ncoa-typ
IPR037077, Nuc_rcpt_coact_Ncoa_int_sf
IPR017426, Nuclear_rcpt_coactivator
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR014935, SRC/p160_LXXLL

The PANTHER Classification System

More...
PANTHERi
PTHR10684, PTHR10684, 1 hit
PTHR10684:SF3, PTHR10684:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07469, DUF1518, 1 hit
PF16279, DUF4927, 1 hit
PF08815, Nuc_rec_co-act, 1 hit
PF00989, PAS, 1 hit
PF08832, SRC-1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038181, Nuclear_receptor_coactivator, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01151, DUF1518, 1 hit
SM00353, HLH, 1 hit
SM00091, PAS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
SSF69125, SSF69125, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59EE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CIFKMSGLGE NLDPLASDSR KRKLPCDTPG QGLTCSGEKR RREQESKYIE
60 70 80 90 100
ELAELISANL SDIDNFNVKP DKCAILKETV RQIRQIKEQG KTISNDDDVQ
110 120 130 140 150
KADVSSTGQG VIDKDSLGPL LLQALDGFLF VVNRDGNIVF VSENVTQYLQ
160 170 180 190 200
YKQEDLVNTS VYNILHEEDR KDFLKNLPKS TVNGVSWTNE TQRQKSHTFN
210 220 230 240 250
CRMLMKTPHD ILEDINASPE MRQRYETMQC FALSQPRAMM EEGEDLQSCM
260 270 280 290 300
ICVARRITTG ERTFPSNPES FITRHDLSGK VVNIDTNSLR SSMRPGFEDI
310 320 330 340 350
IRRCIQRFFS LNDGQSWSQK RHYQEAYLNG HAETPVYRFS LADGTIVTAQ
360 370 380 390 400
TKSKLFRNPV TNDRHGFVST HFLQREQNGY RPNPNPVGQG IRPPMAGCNS
410 420 430 440 450
SVGGMSMSPN QGLQMPSSRA YGLADPSTTG QMSGARYGGS SNIASLTPGP
460 470 480 490 500
GMQSPSSYQN NNYGLNMSSP PHGSPGLAPN QQNIMISPRN RGSPKIASHQ
510 520 530 540 550
FSPVAGVHSP MASSGNTGNH SFSSSSLSAL QAISEGVGTS LLSTLSSPGP
560 570 580 590 600
KLDNSPNMNI TQPSKVSNQD SKSPLGFYCD QNPVESSMCQ SNSRDHLSDK
610 620 630 640 650
ESKESSVEGA ENQRGPLESK GHKKLLQLLT CSSDDRGHSS LTNSPLDSSC
660 670 680 690 700
KESSVSVTSP SGVSSSTSGG VSSTSNMHGS LLQEKHRILH KLLQNGNSPA
710 720 730 740 750
EVAKITAEAT GKDTSSITSC GDGNVVKQEQ LSPKKKENNA LLRYLLDRDD
760 770 780 790 800
PSDALSKELQ PQVEGVDNKM SQCTSSTIPS SSQEKDPKIK TETSEEGSGD
810 820 830 840 850
LDNLDAILGD LTSSDFYNNS ISSNGSHLGT KQQVFQGTNS LGLKSSQSVQ
860 870 880 890 900
SIRPPYNRAV SLDSPVSVGS SPPVKNISAF PMLPKQPMLG GNPRMMDSQE
910 920 930 940 950
NYGSSMGGPN RNVTVTQTPS SGDWGLPNSK AGRMEPMNSN SMGRPGGDYN
960 970 980 990 1000
TSLPRPALGG SIPTLPLRSN SIPGARPVLQ QQQQMLQMRP GEIPMGMGAN
1010 1020 1030 1040 1050
PYGQAAASNQ LGSWPDGMLS MEQVSHGTQN RPLLRNSLDD LVGPPSNLEG
1060 1070 1080 1090 1100
QSDERALLDQ LHTLLSNTDA TGLEEIDRAL GIPELVNQGQ ALEPKQDAFQ
1110 1120 1130 1140 1150
GQEAAVMMDQ KAGLYGQTYP AQGPPMQGGF HLQGQSPSFN SMMNQMNQQG
1160 1170 1180 1190 1200
NFPLQGMHPR ANIMRPRTNT PKQLRMQLQQ RLQGQQFLNQ SRQALELKME
1210 1220 1230 1240 1250
NPTAGGAAVM RPMMQPQVSS QGFLNAQMVA QRSRELLSHH FRQQRVAMMM
1260 1270 1280 1290 1300
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQT QAFSPPPNVT ASPSMDGLLA
1310 1320 1330 1340 1350
GPTMPQAPPQ QFPYQPNYGM GQQPDPAFGR VSSPPNAMMS SRMGPSQNPM
1360 1370 1380 1390 1400
MQHPQAASIY QSSEMKGWPS GNLARNSSFS QQQFAHQGNP AVYSMVHMNG
1410 1420
SSGHMGQMNM NPMPMSGMPM GPDQKYC
Length:1,427
Mass (Da):155,657
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA882D1D5ABE45ACB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB209863 mRNA Translation: BAD93100.1

NCBI Reference Sequences

More...
RefSeqi
NP_001167558.1, NM_001174087.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8202

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209863 mRNA Translation: BAD93100.1
RefSeqiNP_001167558.1, NM_001174087.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8202

Genome annotation databases

GeneIDi8202

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8202
PharmGKBiPA31472

Phylogenomic databases

OMAiHQFSPVT

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8202, 18 hits in 1008 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8202

Gene expression databases

GenevisibleiQ59EE8, HS

Family and domain databases

CDDicd00130, PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR010011, DUF1518
IPR032565, DUF4927
IPR036638, HLH_DNA-bd_sf
IPR028818, NCOA3
IPR009110, Nuc_rcpt_coact
IPR014920, Nuc_rcpt_coact_Ncoa-typ
IPR037077, Nuc_rcpt_coact_Ncoa_int_sf
IPR017426, Nuclear_rcpt_coactivator
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR014935, SRC/p160_LXXLL
PANTHERiPTHR10684, PTHR10684, 1 hit
PTHR10684:SF3, PTHR10684:SF3, 1 hit
PfamiView protein in Pfam
PF07469, DUF1518, 1 hit
PF16279, DUF4927, 1 hit
PF08815, Nuc_rec_co-act, 1 hit
PF00989, PAS, 1 hit
PF08832, SRC-1, 1 hit
PIRSFiPIRSF038181, Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151, DUF1518, 1 hit
SM00353, HLH, 1 hit
SM00091, PAS, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
SSF69125, SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59EE8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59EE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 7, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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