Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 104 (12 Aug 2020)
Sequence version 1 (10 May 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

DnaJ (Hsp40) homolog, subfamily A, member 3 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri221 – 299CR-typePROSITE-ProRule annotationAdd BLAST79

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DnaJ (Hsp40) homolog, subfamily A, member 3 variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    MembraneARBA annotation

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Keywords - PTMi

    MethylationARBA annotation

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q59E88

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q59E88, HS

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    GO - Molecular functioni

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q59E88

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini91 – 156JInterPro annotationAdd BLAST66
    Domaini221 – 299CR-typeInterPro annotationAdd BLAST79

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni441 – 469DisorderedSequence analysisAdd BLAST29

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri221 – 299CR-typePROSITE-ProRule annotationAdd BLAST79

    Keywords - Domaini

    RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

    Phylogenomic databases

    KEGG Orthology (KO)

    More...
    KOi
    K09504

    Database of Orthologous Groups

    More...
    OrthoDBi
    894595at2759

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06257, DnaJ, 1 hit
    cd10719, DnaJ_zf, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.287.110, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01152, DnaJ, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR012724, DnaJ
    IPR002939, DnaJ_C
    IPR001623, DnaJ_domain
    IPR018253, DnaJ_domain_CS
    IPR008971, HSP40/DnaJ_pept-bd
    IPR001305, HSP_DnaJ_Cys-rich_dom
    IPR036410, HSP_DnaJ_Cys-rich_dom_sf
    IPR036869, J_dom_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00226, DnaJ, 1 hit
    PF01556, DnaJ_C, 1 hit
    PF00684, DnaJ_CXXCXGXG, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00625, JDOMAIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00271, DnaJ, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF46565, SSF46565, 1 hit
    SSF49493, SSF49493, 1 hit
    SSF57938, SSF57938, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00636, DNAJ_1, 1 hit
    PS50076, DNAJ_2, 1 hit
    PS51188, ZF_CR, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

    Q59E88-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    ARCSTRWLLV VVGTPRLPAI SGRGARPPRE GVVGAWLSRK LSVPAFASSL
    60 70 80 90 100
    TSCGPRALLT LRPGVSLTGT KHNPFICTAS FHTSAPLAKE DYYQILGVPR
    110 120 130 140 150
    NASQKEIKKA YYQLAKKYHP DTNKDDPKAK EKFSQLAEAY EVLSDEVKRK
    160 170 180 190 200
    QYDAYGSAGF DPGASGSQHS YWKGGPTVDP EELFRKIFGE FSSSSFGDFQ
    210 220 230 240 250
    TVFDQPQEYF MELTFNQAAK GVNKEFTVNI MDTCERCNGK GNEPGTKVQH
    260 270 280 290 300
    CHYCGGSGME TINTGPFVMR STCRRCGGRG SIIISPCVVC RGAGQAKQKK
    310 320 330 340 350
    RVMIPVPAGV EDGQTVRMPV GKREIFITFR VQKSPVFRRD GADIHSDLFI
    360 370 380 390 400
    SIAQALLGGT ARAQGLYETI NVTIPPGTQT DQKIRMGGKG IPRINSYGYG
    410 420 430 440 450
    DHYIHIKIRV PKRLTSRQQS LILSYAEDET DVEGTVNGVT LTSSGGSTMD
    460 470
    SSAGSKARRE AGEDEEGFLS KLKKMFTS
    Length:478
    Mass (Da):52,286
    Last modified:May 10, 2005 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF79D9A5FC3B18DD9
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB209923 mRNA Translation: BAD93160.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_005138.3, NM_005147.5

    Genome annotation databases

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    9093

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:9093

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB209923 mRNA Translation: BAD93160.1
    RefSeqiNP_005138.3, NM_005147.5

    3D structure databases

    SMRiQ59E88
    ModBaseiSearch...

    Proteomic databases

    PRIDEiQ59E88

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    9093

    Genome annotation databases

    GeneIDi9093
    KEGGihsa:9093

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    9093

    Phylogenomic databases

    KOiK09504
    OrthoDBi894595at2759

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    9093, 656 hits in 882 CRISPR screens

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    9093

    Gene expression databases

    GenevisibleiQ59E88, HS

    Family and domain databases

    CDDicd06257, DnaJ, 1 hit
    cd10719, DnaJ_zf, 1 hit
    Gene3Di1.10.287.110, 1 hit
    HAMAPiMF_01152, DnaJ, 1 hit
    InterProiView protein in InterPro
    IPR012724, DnaJ
    IPR002939, DnaJ_C
    IPR001623, DnaJ_domain
    IPR018253, DnaJ_domain_CS
    IPR008971, HSP40/DnaJ_pept-bd
    IPR001305, HSP_DnaJ_Cys-rich_dom
    IPR036410, HSP_DnaJ_Cys-rich_dom_sf
    IPR036869, J_dom_sf
    PfamiView protein in Pfam
    PF00226, DnaJ, 1 hit
    PF01556, DnaJ_C, 1 hit
    PF00684, DnaJ_CXXCXGXG, 1 hit
    PRINTSiPR00625, JDOMAIN
    SMARTiView protein in SMART
    SM00271, DnaJ, 1 hit
    SUPFAMiSSF46565, SSF46565, 1 hit
    SSF49493, SSF49493, 1 hit
    SSF57938, SSF57938, 1 hit
    PROSITEiView protein in PROSITE
    PS00636, DNAJ_1, 1 hit
    PS50076, DNAJ_2, 1 hit
    PS51188, ZF_CR, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59E88_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59E88
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: August 12, 2020
    This is version 104 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again