Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc-transporting ATPase

Gene

ziaA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + Zn2+(In) = ADP + phosphate + Zn2+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19ZincPROSITE-ProRule annotation1
Metal bindingi22ZincPROSITE-ProRule annotation1
Active sitei4254-aspartylphosphate intermediateBy similarity1
Metal bindingi618MagnesiumPROSITE-ProRule annotation1
Metal bindingi622MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Transport, Zinc transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-transporting ATPase (EC:3.6.3.5)
Alternative name(s):
Zn(2+)-translocating P-type ATPase
Gene namesi
Name:ziaA
Ordered Locus Names:slr0798
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 107CytoplasmicBy similarityAdd BLAST107
Transmembranei108 – 128HelicalBy similarityAdd BLAST21
Topological domaini129 – 140ExtracellularBy similarityAdd BLAST12
Transmembranei141 – 160HelicalBy similarityAdd BLAST20
Topological domaini161 – 167CytoplasmicBy similarity7
Transmembranei168 – 187HelicalBy similarityAdd BLAST20
Topological domaini188 – 190ExtracellularBy similarity3
Transmembranei191 – 210HelicalBy similarityAdd BLAST20
Topological domaini211 – 344CytoplasmicBy similarityAdd BLAST134
Transmembranei345 – 363HelicalBy similarityAdd BLAST19
Topological domaini364 – 369ExtracellularBy similarity6
Transmembranei370 – 387HelicalBy similarityAdd BLAST18
Topological domaini388 – 671CytoplasmicBy similarityAdd BLAST284
Transmembranei672 – 693HelicalBy similarityAdd BLAST22
Topological domaini694 – 701ExtracellularBy similarity8
Transmembranei702 – 717HelicalBy similarityAdd BLAST16
Topological domaini718 – 721CytoplasmicBy similarity4

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463331 – 721Zinc-transporting ATPaseAdd BLAST721

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ59998
PRIDEiQ59998

Interactioni

Protein-protein interaction databases

IntActiQ59998, 25 interactors
STRINGi1148.SYNGTS_2744

Structurei

Secondary structure

1721
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ59998
SMRiQ59998
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59998

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 75HMAPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250399
InParanoidiQ59998
KOiK01534
OMAiAVVAKCC
PhylomeDBiQ59998

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
PRINTSiPR00941 CDATPASE
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q59998-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQSSPLKTQ QMQVGGMDCT SCKLKIEGSL ERLKGVAEAS VTVATGRLTV
60 70 80 90 100
TYDPKQVSEI TIQERIAALG YTLAEPKSSV TLNGHKHPHS HREEGHSHSH
110 120 130 140 150
GAGEFNLKQE LLPVLTAIAL FTIAILFEQP LHNTPGQIAE FAVIIPAYLL
160 170 180 190 200
SGWTVLKTAG RNILRGQIFD ENFLMTIATL GALAIHQLPE AVAVMLFFRV
210 220 230 240 250
GELFQEYSVG RSRRSIKALL EARPDTANLK RNGTVQQVSP ETVQVDDLIL
260 270 280 290 300
VKPGEKVPLD GEILGGTSQV DTSALTGESV PGTVKPGDTI LAGMINQSGV
310 320 330 340 350
LTIRVTKLFS ESSIAKVLDL VENASSKKAS TEKFITQFAR YYTPVIVFLS
360 370 380 390 400
LAVALLPPLF IPGADRADWV YRALVLLVIS CPCGLVISIP LGYFGGIGGA
410 420 430 440 450
AKHGILIKGS TFLDSLTAVK TVVFDKTGTL TKGTFKVTQV VTKNGFSESE
460 470 480 490 500
LLTLAAKAES HSTHPIALSI REAYAQSIAD SEVADYEEIA GHGIRAVVQN
510 520 530 540 550
QVVIAGNDRL LHREKIDHDT CDVAGTVVHL AVDGRYGGYI LIADEIKEDA
560 570 580 590 600
VQAIRDLKRM GVEKTVMLTG DSEIVAQSVA QQIGLDAFVA ELLPEEKVDE
610 620 630 640 650
IEQLLDPSGK AKLAFVGDGI NDAPVIARAD VGIAMGGLGS DAAIETADVV
660 670 680 690 700
LMTDAPSKVA EAIHVARKTR QIVVQNIVLA LGIKALFIAL GTIGLATLWE
710 720
AVFADVGVAL LAILNATRIA K
Length:721
Mass (Da):76,884
Last modified:November 1, 1996 - v1
Checksum:iBE187EB3900EC58B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA10707.1
PIRiS77015

Genome annotation databases

EnsemblBacteriaiBAA10707; BAA10707; BAA10707
KEGGisyn:slr0798

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA10707.1
PIRiS77015

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LDINMR-A6-111[»]
2OFGNMR-X1-111[»]
2OFHNMR-X1-111[»]
ProteinModelPortaliQ59998
SMRiQ59998
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ59998, 25 interactors
STRINGi1148.SYNGTS_2744

Proteomic databases

PaxDbiQ59998
PRIDEiQ59998

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10707; BAA10707; BAA10707
KEGGisyn:slr0798

Phylogenomic databases

HOGENOMiHOG000250399
InParanoidiQ59998
KOiK01534
OMAiAVVAKCC
PhylomeDBiQ59998

Miscellaneous databases

EvolutionaryTraceiQ59998

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
PRINTSiPR00941 CDATPASE
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATZN_SYNY3
AccessioniPrimary (citable) accession number: Q59998
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again