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Entry version 86 (11 Dec 2019)
Sequence version 2 (01 Feb 2005)
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Protein

Immunoglobulin A1 protease

Gene

iga

Organism
Streptococcus sanguinis
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleavage of Pro-|-Thr bond in the hinge region of the heavy chain of human IgA. EC:3.4.24.13

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by EDTA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1494ZincCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1495Curated1
Metal bindingi1498ZincBy similarity1
Metal bindingi1518ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M26.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin A1 protease (EC:3.4.24.13)
Short name:
IgA1 protease
Alternative name(s):
IgA-specific zinc metalloproteinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:iga
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus sanguinis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1305 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei106 – 125HelicalSequence analysisAdd BLAST20
Transmembranei132 – 154HelicalSequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini155 – 1854ExtracellularSequence analysisAdd BLAST1700

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1494H → F: Loss of activity. 1 Publication1
Mutagenesisi1495E → K: Loss of activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37Sequence analysisAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002683938 – 99Sequence analysisAdd BLAST62
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000026840100 – 1854Immunoglobulin A1 proteaseAdd BLAST1755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The Gram-positive cell-wall anchor motif LPXTG is located in the N-terminal part, in contrast to such motifs in other known streptococcal and staphylococcal proteins. The protease could be cleaved by the sortase and anchored in the membrane via the two potential N-terminal transmembrane domains, whereas the propeptide located prior to the LPXTG motif would remain attached to the cell wall peptidoglycan by an amide bond (By similarity).By similarity

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q59986

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini256 – 335G5PROSITE-ProRule annotationAdd BLAST80
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati349 – 3681Add BLAST20
Repeati369 – 3882Add BLAST20
Repeati389 – 4063Add BLAST18
Repeati407 – 4264Add BLAST20
Repeati427 – 4465Add BLAST20
Repeati447 – 4666Add BLAST20
Repeati467 – 4867Add BLAST20
Repeati487 – 5068Add BLAST20
Repeati507 – 5269Add BLAST20
Repeati527 – 54610Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni349 – 54610 X 20 AA approximate tandem repeatsAdd BLAST198

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi96 – 100LPXTG sorting signalPROSITE-ProRule annotation5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M26 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011098 G5_dom
IPR011493 GLUG
IPR019948 Gram-positive_anchor
IPR019931 LPXTG_anchor
IPR011505 Peptidase_M26_C_dom
IPR008006 Peptidase_M26_N_dom
IPR005877 YSIRK_signal_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07501 G5, 1 hit
PF07581 Glug, 1 hit
PF00746 Gram_pos_anchor, 1 hit
PF07580 Peptidase_M26_C, 1 hit
PF05342 Peptidase_M26_N, 1 hit
PF04650 YSIRK_signal, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01208 G5, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01168 YSIRK_signal, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51109 G5, 1 hit
PS50847 GRAM_POS_ANCHORING, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q59986-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKFLGEKQT RFAFRKLAVG LVSAAISSLF FVSIVGVDSV QAQEKLNVHY
60 70 80 90 100
KYVTDTEITP QEKELIVSGV PRMPEGNEET YYLVYRLNSN AGAKTLPNTG
110 120 130 140 150
DNNSNTMMAA GLLLTTIGLV VFAVSKRKVQ SKFLLTVLVG ASVGGGLILS
160 170 180 190 200
VDALENGSLL QYNAEYQVSA GESLPSPGEI SGYTYVGYIK DESIKKLLDN
210 220 230 240 250
KIPDNQQNAN VDKEALNQNK KLDYSVSFDK NGLKNQTVGV NTIEPQDEVL
260 270 280 290 300
SGRVAKPELL YKETSIETEI AYGEQIQENP DLAEGTVRVK QEGKPGRKIE
310 320 330 340 350
VVRIFTVDNA EVSREVLSTK IEEATPKIVE KGTKKLEAPS EKPVTSNLVQ
360 370 380 390 400
PEQVAPLPEY TGVQSGAIVE PEQVASLPEY SGTLSGAIVE PEQIEPEIGG
410 420 430 440 450
VQSGAIVEPE QVTPLPEYTG TQAGAVVSPE QVAPLPEYTG TQSGAIVEPA
460 470 480 490 500
QVTPLPEYTG VQSGAIVKPA QVTPLPEYTG TQSGAIVEPE QVTPSPEYTG
510 520 530 540 550
VQAGAIVEPE QVASLPEYTG SQAGAIVEPE QVEPPQEYTG NIEPAAPEAE
560 570 580 590 600
NPTEKAQEPK EQKQEPEKNI ELRNVSDVEL YSLADGKYKQ HVSLDAIPSN
610 620 630 640 650
QENYFVKVKS SKFKDVFLPI SSIVDSTKDG QPVYKITASA EKLKQDVNNK
660 670 680 690 700
YEDNFTFYLA KKAEREVTNF TSFSNLVQAI NNNLNGTYYL AASLNANEVE
710 720 730 740 750
LENGASSYIK GRFTGKLFGS KDGKNYAIYN LKKPLFDTLS AATVENLTLK
760 770 780 790 800
DVNISGKTDI GALANEANNA TRINNVHVDG VLAGERGIGG LVWKADNSKI
810 820 830 840 850
SNSSFKGRIV NSYETKAPYN IGGLVGQLTG INALVDKSKA TITISSNADS
860 870 880 890 900
TNQTVGGLAG LVEKDALISN SYAEGNINNV KRFGSVAGVA GYLWDRDSSE
910 920 930 940 950
ERHAGRLHNV LSDINVMNGN AISGYHYRGM RITDSYSNKD NRVYKVTLEK
960 970 980 990 1000
DEVVTKESLE ERGTILDVSQ IASKKSEINS LSAPKVETLL TSTNKESDFS
1010 1020 1030 1040 1050
KVKDYQASRA LAYKNIEKLL PFYNKATIVK YGNLVKEDST LYEKEILSAV
1060 1070 1080 1090 1100
MMKDNEVITD IASHKEAANK LLIHYKDHSS EKLDLTYQSD FSKLAEYRVG
1110 1120 1130 1140 1150
DTGLIYTPNQ FLQNHSSIVN EVLPDLKAVD YQSEAIRNTL GISSGVSLTE
1160 1170 1180 1190 1200
LYLEEQFAKT KENLANTLEK LLSADAVIAS ENQTINGYVV DKIKRNKEAL
1210 1220 1230 1240 1250
LLGLTYLERW YNFNYGDVNV KDLVMYHMDF FGKGNVSPLD TIIELGKSGF
1260 1270 1280 1290 1300
NNLLAKNNVD AYNISLANNN ATKDLFSTLA NYREVFLPNK TNNQWFKEQT
1310 1320 1330 1340 1350
KAYIVEEKSA IDEVRVKQEQ AGSKYSIGVY DRITSDTWKY RNMVLPLLTM
1360 1370 1380 1390 1400
PERSVFVIST ISSLGFGAYD RYRNNEHRAG AELNKFVEDN AQETAKRQRD
1410 1420 1430 1440 1450
HYDYWYRILD EQGREKLYRN ILVYDAYKFG DDTTVDKATV EAQFDSSNPA
1460 1470 1480 1490 1500
MKYFFGPVGN KVVHNKHGAY ATGDSVYYMG YRMLDKDGAI TYTHEMTHDS
1510 1520 1530 1540 1550
DNEIYLGGYG RRSGLGPEFF AKGLLQAPDH PDDATITVNS ILKYDKNDAS
1560 1570 1580 1590 1600
EKSRLQVLDP TKRFQNADDL KNYVHNMFDV IYMLEYLEGM SIVNRLSDVQ
1610 1620 1630 1640 1650
KVNALRKIEN KYVRDADGND VYATNVIKNI TMADAQKLNS FNSLIENDIL
1660 1670 1680 1690 1700
SAREYKNGDV ERNGYHTIKL FSPIYSALSS EKGTPGDLMG RRIAYELLAA
1710 1720 1730 1740 1750
KGFKDGMVPY ISNQYEDDAK QNGKTISIYG KTRGLVTDDL VLRKVFNGQF
1760 1770 1780 1790 1800
NNWTEFKKAM YEERKNKFDS LNKVTFDDTR QPWTSYATKT ISTVEELQTL
1810 1820 1830 1840 1850
MDEAVLQDAN DNWYSWSGYK PEYNSAVHKL KKAVFKAYLD QTKDFRKSIF

ENQK
Length:1,854
Mass (Da):206,024
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE2149C0BC7FA4DE
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA26901 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L29504 Genomic DNA Translation: AAA26901.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...
PIRi
A60272
B60272

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29504 Genomic DNA Translation: AAA26901.1 Frameshift.
PIRiA60272
B60272

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiM26.001

Proteomic databases

PRIDEiQ59986

Family and domain databases

InterProiView protein in InterPro
IPR011098 G5_dom
IPR011493 GLUG
IPR019948 Gram-positive_anchor
IPR019931 LPXTG_anchor
IPR011505 Peptidase_M26_C_dom
IPR008006 Peptidase_M26_N_dom
IPR005877 YSIRK_signal_dom
PfamiView protein in Pfam
PF07501 G5, 1 hit
PF07581 Glug, 1 hit
PF00746 Gram_pos_anchor, 1 hit
PF07580 Peptidase_M26_C, 1 hit
PF05342 Peptidase_M26_N, 1 hit
PF04650 YSIRK_signal, 1 hit
SMARTiView protein in SMART
SM01208 G5, 1 hit
TIGRFAMsiTIGR01168 YSIRK_signal, 1 hit
PROSITEiView protein in PROSITE
PS51109 G5, 1 hit
PS50847 GRAM_POS_ANCHORING, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGA1_STRSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59986
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: December 11, 2019
This is version 86 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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