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Protein

Beta-galactosidase

Gene

lacZ

Organism
Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei382Proton donorBy similarity1
Active sitei463NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
OrganismiRhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri382 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3484

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000576741 – 755Beta-galactosidaseAdd BLAST755

Interactioni

Chemistry databases

BindingDBiQ59750

Structurei

3D structure databases

ProteinModelPortaliQ59750
SMRiQ59750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
SUPFAMiSSF49303 SSF49303, 1 hit
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q59750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSVTSFNDS WVFSEASTRD AERSGRVSRS ACRTNAVELP FNYFDERCYQ
60 70 80 90 100
RAFTYQRVLA WRPDFSQGSR SSSTRQWPMR SCISTAKRSS RIRDGYTPFE
110 120 130 140 150
ARLTDRLLEG DNLITVKIDG SENPEIPPFG AGIDYLTYAG IYRDVWLKVT
160 170 180 190 200
DPVSIANIKI ETRDVLSDHK AVSLRCDLSN PQGLSFSGTI SALLKNAAGE
210 220 230 240 250
VLAEVAGETT GQSLAFEMDG LRGLSLWDID DPVLYVIEVE LRTGQGFRLL
260 270 280 290 300
RRAFRLPHGE FTTEGFRLNG RPLKIRGLNR HQSFPYVGLR MGRTAKGSAH
310 320 330 340 350
ADIMNAHRLH CNLVRTSHYP QSKWFLDHCD RIGLLVFARN PRLAAYRWGG
360 370 380 390 400
METGGNPERP PHRSSATGTT RLSYIWGVRI NESQDSHDFY AETNRLAREL
410 420 430 440 450
DPTRQTGGVR YITDSEFLED VYTMNDFILG NEELPGANRP GTALRPQQEC
460 470 480 490 500
TGLPRKVPYL ITEFGGHMYP TKIYDQEQRQ AEHVRRHLEV LNAAYARNPG
510 520 530 540 550
ISGAIGWCMF DYNTTRISAP ATGSAITASW TCSASPKFAA YVYASQCDPS
560 570 580 590 600
EEIVMKPVTF WARGDDDIGG VLPLIVLTNC DEIELKYGSL TKRVGPDREN
610 620 630 640 650
FPHLPHPPVV IDHRHFTKDE LGVWGMKWES AEFTGFIAGK PVADLRMAAD
660 670 680 690 700
PVPTTLQVEA DSKTLRREGR DTVRLILRAL DQAGNVLPFL NDAVDIEIHG
710 720 730 740 750
PARLVGPARI VLQGGSGFLA GVHGRRRHAS SRSRRRGSAA AKLDLVALAD

GAASA
Length:755
Mass (Da):84,149
Last modified:November 1, 1996 - v1
Checksum:i09E339A92CC0D366
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20757 Genomic DNA Translation: AAA26296.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20757 Genomic DNA Translation: AAA26296.1

3D structure databases

ProteinModelPortaliQ59750
SMRiQ59750
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiQ59750
ChEMBLiCHEMBL3484

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
SUPFAMiSSF49303 SSF49303, 1 hit
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBGAL_RHIML
AccessioniPrimary (citable) accession number: Q59750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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