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Protein

Bacterioferritin

Gene

bfr

Organism
Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
  • Fe cationNote: Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18Iron 11
Metal bindingi51Iron 11
Metal bindingi51Iron 21
Metal bindingi52Iron (heme axial ligand); shared with dimeric partner1
Metal bindingi54Iron 11
Metal bindingi94Iron 21
Metal bindingi127Iron 11
Metal bindingi127Iron 21
Metal bindingi130Iron 21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin (EC:1.16.3.1)
Short name:
BFR
Gene namesi
Name:bfr
OrganismiRhodobacter capsulatus (Rhodopseudomonas capsulata)
Taxonomic identifieri1061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001926111 – 161BacterioferritinAdd BLAST161

Interactioni

Subunit structurei

Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 34Combined sources30
Helixi38 – 64Combined sources27
Helixi83 – 111Combined sources29
Helixi114 – 144Combined sources31
Helixi146 – 152Combined sources7

3D structure databases

ProteinModelPortaliQ59738
SMRiQ59738
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59738

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 145Ferritin-like diironPROSITE-ProRule annotationAdd BLAST145

Sequence similaritiesi

Belongs to the bacterioferritin family.Curated

Phylogenomic databases

eggNOGiENOG4108UQY Bacteria
COG2193 LUCA
HOGENOMiHOG000262383

Family and domain databases

CDDicd00907 Bacterioferritin, 1 hit
Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR002024 Bacterioferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR008331 Ferritin_DPS_dom
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
PIRSFiPIRSF002560 Bacterioferritin, 1 hit
PRINTSiPR00601 BACFERRITIN
SUPFAMiSSF47240 SSF47240, 1 hit
TIGRFAMsiTIGR00754 bfr, 1 hit
PROSITEiView protein in PROSITE
PS00549 BACTERIOFERRITIN, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q59738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGDAKVIEF LNAALRSELT AISQYWVHFR LQEDWGLAKM AKKSREESIE
60 70 80 90 100
EMGHADKIIA RILFLEGHPN LQKLDPLRIG EGPRETLECD LAGEHDALKL
110 120 130 140 150
YREARDYCAE VGDIVSKNIF ESLITDEEGH VDFLETQISL YDRLGPQGFA
160
LLNAAPMDAA E
Length:161
Mass (Da):18,173
Last modified:November 1, 1997 - v1
Checksum:i9E534CBC531EC709
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54247 Genomic DNA Translation: CAA91017.1
PIRiS48182

Genome annotation databases

GeneIDi31489850

Similar proteinsi

Entry informationi

Entry nameiBFR_RHOCA
AccessioniPrimary (citable) accession number: Q59738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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