Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Proteus mirabilis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Porphobilinogen deaminase (hemC), Porphobilinogen deaminase (hemC), Porphobilinogen deaminase (hemC), Porphobilinogen deaminase (hemC)
  3. Uroporphyrinogen-III synthase (hemD)
  4. Uroporphyrinogen decarboxylase (hemE), Uroporphyrinogen decarboxylase (hemE), Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processPorphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
OrganismiProteus mirabilis
Taxonomic identifieri584 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352441 – 199Uroporphyrinogen-III synthaseAdd BLAST199

Structurei

3D structure databases

ProteinModelPortaliQ59683
SMRiQ59683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd06578 HemD, 1 hit
InterProiView protein in InterPro
IPR036108 4pyrrol_syn_uPrphyn_synt_sf
IPR003754 4pyrrol_synth_uPrphyn_synth
PfamiView protein in Pfam
PF02602 HEM4, 1 hit
SUPFAMiSSF69618 SSF69618, 1 hit

Sequencei

Sequence statusi: Complete.

Q59683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILITRPSP AGEQLTQRLI DAGKHAFHAP LIEIAAGKEL SILENKLNKL
60 70 80 90 100
STGDYLFLLS KNAVWYANWQ LNQLQQSWPD TLFYYGIGQS TAEEFQQLTA
110 120 130 140 150
HSIRYPEFGE TSEDLLALSS LQQIENKRVL LLRGNGGREL LATTLRQRGA
160 170 180 190
IVDECECYQR LFIDYVSEEF ALKWKNAQVE YLCGHQCEML QQLLSSRWI
Length:199
Mass (Da):22,799
Last modified:November 1, 1997 - v1
Checksum:i4CC1CC06C26D31BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22969 Genomic DNA Translation: AAC44328.1

Similar proteinsi

Entry informationi

Entry nameiHEM4_PROMI
AccessioniPrimary (citable) accession number: Q59683
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 25, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health