UniProtKB - Q59677 (MUTB_PORGI)
Protein
Methylmalonyl-CoA mutase large subunit
Gene
mutB
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Functioni
Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.By similarity
Catalytic activityi
- EC:5.4.99.2
Cofactori
: propanoyl-CoA degradation Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- no protein annotated in this organism
- no protein annotated in this organism
- Methylmalonyl-CoA mutase small subunit (mutA), Methylmalonyl-CoA mutase large subunit (mutB)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 600 | Cobalt (cobalamin axial ligand)By similarity | 1 |
GO - Molecular functioni
- cobalamin binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- methylmalonyl-CoA mutase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Isomerase |
Ligand | Cobalamin, Cobalt, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00945;UER00910 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:mutB Synonyms:mcmB Ordered Locus Names:PG_1657 |
Organismi | Porphyromonas gingivalis (strain ATCC BAA-308 / W83) |
Taxonomic identifieri | 242619 [NCBI] |
Taxonomic lineagei | Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194272 | 1 – 715 | Methylmalonyl-CoA mutase large subunitAdd BLAST | 715 |
Proteomic databases
PRIDEi | Q59677 |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta chain.
Protein-protein interaction databases
STRINGi | 242619.PG_1657 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 587 – 715 | B12-bindingPROSITE-ProRule annotationAdd BLAST | 129 |
Sequence similaritiesi
Belongs to the methylmalonyl-CoA mutase family.Curated
Phylogenomic databases
eggNOGi | COG1884, Bacteria COG2185, Bacteria |
HOGENOMi | CLU_009523_3_1_10 |
OMAi | GPYATMY |
OrthoDBi | 154460at2 |
Family and domain databases
InterProi | View protein in InterPro IPR006159, Acid_CoA_mut_C IPR016176, Cbl-dep_enz_cat IPR006158, Cobalamin-bd IPR036724, Cobalamin-bd_sf IPR006099, MeMalonylCoA_mutase_a/b_cat IPR006098, MMCoA_mutase_a_cat |
Pfami | View protein in Pfam PF02310, B12-binding, 1 hit PF01642, MM_CoA_mutase, 1 hit |
SUPFAMi | SSF51703, SSF51703, 1 hit SSF52242, SSF52242, 1 hit |
TIGRFAMsi | TIGR00640, acid_CoA_mut_C, 1 hit TIGR00641, acid_CoA_mut_N, 1 hit |
PROSITEi | View protein in PROSITE PS51332, B12_BINDING, 1 hit PS00544, METMALONYL_COA_MUTASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q59677-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKPNYKDIDI KSAGFVAKDA TRWAEEKGIV ADWRTPEQIM VKPLYTKDDL
60 70 80 90 100
EGMEHLDYVS GLPPFLRGPY SGMYPMRPWT IRQYAGFSTA EESNAFYRRN
110 120 130 140 150
LASGQKGLSV AFDLATHRGY DADHSRVVGD VGKAGVSICS LEDMKVLFDG
160 170 180 190 200
IPLSKMSVSM TMNGAVLPIL AFYINAGLEQ GAKLEEMAGT IQNDILKEFM
210 220 230 240 250
VRNTYIYPPE FSMRIIADIF EYTSQNMPKF NSISISGYHM QEAGATADIE
260 270 280 290 300
MAYTLADGMQ YLKAGIDAGI DVDAFAPRLS FFWAIGVNHF MEIAKMRAAR
310 320 330 340 350
LLWAKIVKSF GAKNPKSLAL RTHSQTSGWS LTEQDPFNNV GRTCIEAMAA
360 370 380 390 400
ALGHTQSLHT NALDEAIALP TDFSARIARN TQIYIQEETL VCKEIDPWGG
410 420 430 440 450
SYYVESLTNE LVHKAWTLIK EVQEMGGMAK AIETGLPKLR IEEAAARTQA
460 470 480 490 500
RIDSHQQVIV GVNKYRLPKE DPIDILEIDN TAVRKQQIER LNDLRSHRDE
510 520 530 540 550
KAVQEALEAI TKCVETKEGN LLDLAVKAAG LRASLGEISD ACEKVVGRYK
560 570 580 590 600
AVIRTISGVY SSESGEDKDF AHAKELAEKF AKKEGRQPRI MIAKMGQDGH
610 620 630 640 650
DRGAKVVATG YADCGFDVDM GPLFQTPEEA ARQAVENDVH VMGVSSLAAG
660 670 680 690 700
HKTLIPQVIA ELEKLGRPDI LVTAGGVIPA QDYDFLYQAG VAAIFGPGTP
710
VAYSAAKVLE ILLEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L30136 Genomic DNA Translation: AAB51084.1 AE015924 Genomic DNA Translation: AAQ66676.1 |
PIRi | JC4560 |
RefSeqi | WP_005875477.1, NC_002950.2 |
Genome annotation databases
EnsemblBacteriai | AAQ66676; AAQ66676; PG_1657 |
KEGGi | pgi:PG_1657 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L30136 Genomic DNA Translation: AAB51084.1 AE015924 Genomic DNA Translation: AAQ66676.1 |
PIRi | JC4560 |
RefSeqi | WP_005875477.1, NC_002950.2 |
3D structure databases
SMRi | Q59677 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 242619.PG_1657 |
Proteomic databases
PRIDEi | Q59677 |
Genome annotation databases
EnsemblBacteriai | AAQ66676; AAQ66676; PG_1657 |
KEGGi | pgi:PG_1657 |
Phylogenomic databases
eggNOGi | COG1884, Bacteria COG2185, Bacteria |
HOGENOMi | CLU_009523_3_1_10 |
OMAi | GPYATMY |
OrthoDBi | 154460at2 |
Enzyme and pathway databases
UniPathwayi | UPA00945;UER00910 |
Family and domain databases
InterProi | View protein in InterPro IPR006159, Acid_CoA_mut_C IPR016176, Cbl-dep_enz_cat IPR006158, Cobalamin-bd IPR036724, Cobalamin-bd_sf IPR006099, MeMalonylCoA_mutase_a/b_cat IPR006098, MMCoA_mutase_a_cat |
Pfami | View protein in Pfam PF02310, B12-binding, 1 hit PF01642, MM_CoA_mutase, 1 hit |
SUPFAMi | SSF51703, SSF51703, 1 hit SSF52242, SSF52242, 1 hit |
TIGRFAMsi | TIGR00640, acid_CoA_mut_C, 1 hit TIGR00641, acid_CoA_mut_N, 1 hit |
PROSITEi | View protein in PROSITE PS51332, B12_BINDING, 1 hit PS00544, METMALONYL_COA_MUTASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MUTB_PORGI | |
Accessioni | Q59677Primary (citable) accession number: Q59677 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families