Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 127 (16 Oct 2019)
Sequence version 2 (11 Jan 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

thiamine diphosphateBy similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PAER208964:G1FZ6-5131-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aceE
Synonyms:aceA
Ordered Locus Names:PA5015
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri208964 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002438 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Pseudomonas genome database

More...
PseudoCAPi
PA5015

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001622471 – 882Pyruvate dehydrogenase E1 componentAdd BLAST882

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q59637

PRoteomics IDEntifications database

More...
PRIDEi
Q59637

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q59637

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DAQ Bacteria
COG2609 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115215

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q59637

KEGG Orthology (KO)

More...
KOi
K00163

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDEYRTF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q59637

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02017 TPP_E1_EcPDC_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.920, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035807 PDC_E1_N
IPR004660 PDH_E1
IPR041621 PDH_E1_M
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005474 Transketolase_N

The PANTHER Classification System

More...
PANTHERi
PTHR43825:SF3 PTHR43825:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17831 PDH_E1_M, 1 hit
PF00456 Transketolase_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000156 Pyruvate_dh_E1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00759 aceE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q59637-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQDLDPVETQ EWLDALESVL DREGEDRAHY LMTRMGELAS RSGTQLPYAI
60 70 80 90 100
TTPYRNTIPV THEARMPGDL FMERRIRSLV RWNALAMVMR ANKHDPDLGG
110 120 130 140 150
HISTFASSAT LYDIGFNYFF QAPTDEHGGD LVFFQGHASP GVYARAFLEG
160 170 180 190 200
RISEEQLENF RQEVDGNGLS SYPHPWLMPD FWQFPTVSMG LGPIQAIYQA
210 220 230 240 250
RFMKYLESRG FIPAGKQKVW CFMGDGECDE PESLGAISLA GREKLDNLIF
260 270 280 290 300
VINCNLQRLD GPVRGNAKII QELEGVFRGA EWNVNKVIWG RFWDPLFAKD
310 320 330 340 350
TAGLLQQRMD EVIDGEYQNY KAKDGAYVRE HFFGARPELL EMVKDLSDEE
360 370 380 390 400
IWKLNRGGHD PYKVYAAYHQ AVNHKGQPTV ILAKTIKGYG TGSGEAKNIA
410 420 430 440 450
HNVKKVDVDS LRAFRDKFDI PVKDADLEKL PFYKPEEGSA EAKYLAERRA
460 470 480 490 500
ALGGFMPVRR QKSMSVPVPP LETLKAMLDG SGDREISTTM AFVRIISQLV
510 520 530 540 550
KDKELGPRIV PIVPDEARTF GMEGMFRQLG IYSSVGQLYE PVDKDQVMFY
560 570 580 590 600
REDKKGQILE EGINEAGAMS SWIAAGTSYS THNQPMLPFY IFYSMFGFQR
610 620 630 640 650
IGDLAWAAGD SRAHGFLIGG TAGRTTLNGE GLQHEDGHSH LLASTIPNCR
660 670 680 690 700
TYDPTYAYEL AVIIREGSRQ MIEEQQDIFY YITVMNENYV QPAMPKGAEE
710 720 730 740 750
GIIKGMYLLE EDKKEAAHHV QLLGSGTILR EVEEAAKLLR NDFGIGADVW
760 770 780 790 800
SVPSFNELRR DGLAVERWNR LHPGQKPKQS YVEECLGGRR GPVIASTDYM
810 820 830 840 850
KLYAEQIRQW VPSKEYKVLG TDGFGRSDSR KKLRNFFEVD RHWVVLAALE
860 870 880
ALADRGDIEP KVVAEAIAKY GIDPEKRNPL DC
Length:882
Mass (Da):99,564
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FD387B8332E24D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76 – 78IRS → DPLP in AAC45353 (PubMed:9171401).Curated3
Sequence conflicti149 – 156EGRISEEQ → GRPHQRRNK in AAC45353 (PubMed:9171401).Curated8
Sequence conflicti167 – 174NGLSSYPH → TACPPIRT in AAC45353 (PubMed:9171401).Curated8
Sequence conflicti377Q → H in AAC45353 (PubMed:9171401).Curated1
Sequence conflicti388G → V in AAC45353 (PubMed:9171401).Curated1
Sequence conflicti392G → A in AAC45353 (PubMed:9171401).Curated1
Sequence conflicti408 – 409Missing in AAC45353 (PubMed:9171401).Curated2
Sequence conflicti517A → G in AAC45353 (PubMed:9171401).Curated1
Sequence conflicti671Missing in AAC45353 (PubMed:9171401).Curated1
Sequence conflicti740R → H in AAC45353 (PubMed:9171401).Curated1
Sequence conflicti744 – 746GIG → DIV in AAC45353 (PubMed:9171401).Curated3
Sequence conflicti760 – 765RDGLAV → HDDLTL in AAC45353 (PubMed:9171401).Curated6
Sequence conflicti788 – 791GRRG → APSR in AAC45353 (PubMed:9171401).Curated4
Sequence conflicti821Missing in AAC45353 (PubMed:9171401).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U47920 Genomic DNA Translation: AAC45353.1
AE004091 Genomic DNA Translation: AAG08400.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G83018

NCBI Reference Sequences

More...
RefSeqi
NP_253702.1, NC_002516.2
WP_003114556.1, NZ_QZGE01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG08400; AAG08400; PA5015

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
881326

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pae:PA5015

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|208964.12.peg.5255

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47920 Genomic DNA Translation: AAC45353.1
AE004091 Genomic DNA Translation: AAG08400.1
PIRiG83018
RefSeqiNP_253702.1, NC_002516.2
WP_003114556.1, NZ_QZGE01000002.1

3D structure databases

SMRiQ59637
ModBaseiSearch...

Proteomic databases

PaxDbiQ59637
PRIDEiQ59637

Genome annotation databases

EnsemblBacteriaiAAG08400; AAG08400; PA5015
GeneIDi881326
KEGGipae:PA5015
PATRICifig|208964.12.peg.5255

Organism-specific databases

PseudoCAPiPA5015

Phylogenomic databases

eggNOGiENOG4105DAQ Bacteria
COG2609 LUCA
HOGENOMiHOG000115215
InParanoidiQ59637
KOiK00163
OMAiPDEYRTF
PhylomeDBiQ59637

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-5131-MONOMER

Family and domain databases

CDDicd02017 TPP_E1_EcPDC_like, 1 hit
Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR035807 PDC_E1_N
IPR004660 PDH_E1
IPR041621 PDH_E1_M
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005474 Transketolase_N
PANTHERiPTHR43825:SF3 PTHR43825:SF3, 1 hit
PfamiView protein in Pfam
PF17831 PDH_E1_M, 1 hit
PF00456 Transketolase_N, 1 hit
PIRSFiPIRSF000156 Pyruvate_dh_E1, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00759 aceE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiODP1_PSEAE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59637
Secondary accession number(s): Q9HUF3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: October 16, 2019
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again