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UniProtKB - Q59332 (PLD_CORUL)
Protein
Phospholipase D
Gene
pld
Organism
Corynebacterium ulcerans
Status
Functioni
Virulence factor affecting bacterial dissemination and survival within the host. Has magnesium-dependent catalytic activity toward sphingomyelin (SM) and acyl- and alkyl-lysophosphatidylcholine (LPC), but not toward sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC). Lysophosphatidic acid (LPA), assumed to result from LPC hydrolysis, evokes pathophysiological responses after LPA receptor internalization. Shows hemolytic activity.
By similarityCatalytic activityi
- EC:3.1.4.41By similarity
- 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H+By similarity
Cofactori
Mg2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 44 | Sequence analysis | 1 |
GO - Molecular functioni
- sphingomyelin phosphodiesterase D activity Source: UniProtKB-EC
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism, Virulence |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pld |
Organismi | Corynebacterium ulcerans |
Taxonomic identifieri | 65058 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Corynebacteriaceae › Corynebacterium |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_0000022067 | 25 – 307 | Phospholipase DAdd BLAST | 283 |
Family & Domainsi
Sequence similaritiesi
Belongs to the sphingomyelinase D/phospholipase D family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502ZB0H, Bacteria |
Family and domain databases
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR017946, PLC-like_Pdiesterase_TIM-brl IPR016674, SMase_D/PLipase_D |
PIRSFi | PIRSF016632, Phospholipase_actinobac/fun, 1 hit |
SUPFAMi | SSF51695, SSF51695, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q59332-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKKVVLFLS IIMGILFPVG NAVATPVSHD AASTGNRPVY AIAHRVLTTQ
60 70 80 90 100
GVDDAVAIGA NALEIDFTAW RGGWWADHDG IPTSAGATAE AIFKHIAEKR
110 120 130 140 150
NQGANITFTW LDIKNPDYCT DPHSVCSINA LRDLARKYLE PAGVRVLYGF
160 170 180 190 200
YKTVGGPGWK TITSDLRDNE AVALSGPTRD VLNDFAKAGD KILTKQKIAD
210 220 230 240 250
YGYYDINQGF GDCYGDGNKT CDQLRKSSEA RDQGKLGKTF GWTITTGQDD
260 270 280 290 300
RVNDLLGKAH VDGMIFGFKV THFYRHADTE NSFKAIKTWV DKHSDTHHLA
TAADNPW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L16585 Genomic DNA Translation: AAB68401.1 |
RefSeqi | WP_023634800.1, NZ_UFXR01000001.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L16585 Genomic DNA Translation: AAB68401.1 |
RefSeqi | WP_023634800.1, NZ_UFXR01000001.1 |
3D structure databases
AlphaFoldDBi | Q59332 |
SMRi | Q59332 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 65058.Cul210931_0042 |
Phylogenomic databases
eggNOGi | ENOG502ZB0H, Bacteria |
Family and domain databases
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR017946, PLC-like_Pdiesterase_TIM-brl IPR016674, SMase_D/PLipase_D |
PIRSFi | PIRSF016632, Phospholipase_actinobac/fun, 1 hit |
SUPFAMi | SSF51695, SSF51695, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLD_CORUL | |
Accessioni | Q59332Primary (citable) accession number: Q59332 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |