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Entry version 134 (22 Apr 2020)
Sequence version 2 (11 May 2016)
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Protein

Glucanase

Gene

cbhA

Organism
Hungateiclostridium thermocellum (Clostridium thermocellum)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi421Calcium 1Combined sources1
Metal bindingi428Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi431Calcium 1Combined sources1
Metal bindingi433Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi435Calcium 1Combined sources1
Metal bindingi438Calcium 1Combined sources1
Metal bindingi557Calcium 2Combined sources1
Metal bindingi559Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi562Calcium 2Combined sources1
Metal bindingi563Calcium 2Combined sources1
Metal bindingi617Calcium 2; via carbonyl oxygenCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei737PROSITE-ProRule annotation1
Active sitei786PROSITE-ProRule annotation1
Active sitei795PROSITE-ProRule annotation1
Metal bindingi1047Calcium 3Combined sources1
Metal bindingi1049Calcium 3Combined sources1
Metal bindingi1112Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi1115Calcium 3Combined sources1
Metal bindingi1116Calcium 3Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidasePROSITE-ProRule annotationImported, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradationPROSITE-ProRule annotation
LigandCalciumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CTHE637887:G1GQP-1842-MONOMER
GCF_001692755:G1EZZ-1840-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.91 1530

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM3 Carbohydrate-Binding Module Family 3
CBM4 Carbohydrate-Binding Module Family 4
GH9 Glycoside Hydrolase Family 9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GlucanaseUniRule annotation (EC:3.2.1.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cbhAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHungateiclostridium thermocellum (Clostridium thermocellum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1515 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHungateiclostridiaceaeHungateiclostridium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02717 Cellotetraose

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27UniRule annotationAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502398698228 – 1230GlucanaseUniRule annotationAdd BLAST1203

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q59325

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q59325

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 9 (cellulase E) family.PROSITE-ProRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105E08 Bacteria
COG2730 LUCA
COG3979 LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02850 E_set_Cellulase_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1330.10, 1 hit
1.50.10.10, 1 hit
2.60.120.260, 1 hit
2.60.40.10, 3 hits
2.60.40.710, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR004197 Cellulase_Ig-like
IPR003305 CenC_carb-bd
IPR002105 Dockerin_1_rpt
IPR016134 Dockerin_dom
IPR036439 Dockerin_dom_sf
IPR018247 EF_Hand_1_Ca_BS
IPR008979 Galactose-bd-like_sf
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR018221 Glyco_hydro_9_His_AS
IPR013783 Ig-like_fold
IPR014756 Ig_E-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00942 CBM_3, 1 hit
PF02018 CBM_4_9, 1 hit
PF02927 CelD_N, 1 hit
PF00404 Dockerin_1, 1 hit
PF00759 Glyco_hydro_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01067 CBM_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 1 hit
SSF49384 SSF49384, 1 hit
SSF49785 SSF49785, 1 hit
SSF63446 SSF63446, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51172 CBM3, 1 hit
PS00448 CLOS_CELLULOSOME_RPT, 1 hit
PS51766 DOCKERIN, 1 hit
PS00018 EF_HAND_1, 1 hit
PS00592 GH9_2, 1 hit
PS00698 GH9_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q59325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFRRSICTA VLLAVLLTLL VPTSVFALED NSSTLPPYKN DLLYERTFDE
60 70 80 90 100
GLCYPWHTCE DSGGKCSFDV VDVPGQPGNK AFAVTVLDKG QNRWSVQMRH
110 120 130 140 150
RGLTLEQGHT YRVRLKIWAD ASCKVYIKIG QMGEPYAEYW NNKWSPYTLT
160 170 180 190 200
AGKVLEIDET FVMDKPTDDT CEFTFHLGGE LAATPPYTVY LDDVSLYDPE
210 220 230 240 250
YTKPVEYILP QPDVRVNQVG YLPEGKKVAT VVCNSTQPVK WQLKNAAGVV
260 270 280 290 300
VLEGYTEPKG LDKDSQDYVH WLDFSDFATE GIGYYFELPT VNSPTNYSHP
310 320 330 340 350
FDIRKDIYTQ MKYDALAFFY HKRSGIPIEM PYAGGEQWTR PAGHIGIEPN
360 370 380 390 400
KGDTNVPTWP QDDEYAGIPQ KNYTKDVTGG WYDAGDHGKY VVNGGIAVWT
410 420 430 440 450
LMNMYERAKI RGLDNWGPYR DGGMNIPEQN NGYPDILDEA RWEIEFFKKM
460 470 480 490 500
QVTEKEDPSI AGMVHHKIHD FRWTALGMLP HEDPQPRYLR PVSTAATLNF
510 520 530 540 550
AATLAQSARL WKDYDPTFAA DCLEKAEIAW QAALKHPDIY AEYTPGSGGP
560 570 580 590 600
GGGPYNDDYV GDEFYWAACE LYVTTGKDEY KNYLMNSPHY LEMPAKMGEN
610 620 630 640 650
GGANGEDNGL WGCFTWGTTQ GLGTITLALV ENGLPATDIQ KARNNIAKAA
660 670 680 690 700
DRWLENIEEQ GYRLPIKQAE DERGGYPWGS NSFILNQMIV MGYAYDFTGD
710 720 730 740 750
SKYLDGMFDG ISYLLGRNAM DQSYVTGYGE RPLQNPHDRF WTPQTSKRFP
760 770 780 790 800
APPPGIISGG PNSRFEDPTI NAAVKKDTPP QKCFIDHTDS WSTNEITVNW
810 820 830 840 850
NAPFAWVTAY LDEQYTDSET DKVTIDSPVA GERFEAGKDI NISATVKSKT
860 870 880 890 900
PVSKVEFYNG DTLISSDTTA PYTAKITGAA VGAYNLKAVA VLSDGRRIES
910 920 930 940 950
PVTPVLVKVI VKPTVKLTAP KSNVVAYGNE FLKITATASD SDGKISRVDF
960 970 980 990 1000
LVDGEVIGSD REAPYEYEWK AVEGNHEISV IAYDDDDAAS TPDSVKIFVK
1010 1020 1030 1040 1050
QARDVKVQYL CENTQTSTQE IKGKFNIVNT GNRDYSLKDI VLRYYFTKEH
1060 1070 1080 1090 1100
NSQLQFICYY TPIGSGNLIP SFGGSGDEHY LQLEFKDVKL PAGGQTGEIQ
1110 1120 1130 1140 1150
FVIRYADNSF HDQSNDYSFD PTIKAFQDYG KVTLYKNGEL VWGTPPGGTE
1160 1170 1180 1190 1200
PEEPEEPEEP EEPAIVYGDC NDDGKVNSTD VAVMKRYLKK ENVNINLDNA
1210 1220 1230
DVNADGKVNS TDFSILKRYV MKNIEELPYR
Length:1,230
Mass (Da):137,827
Last modified:May 11, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEA2E7115FB81C28
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X80993 Genomic DNA Translation: CAA56918.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S47466

NCBI Reference Sequences

More...
RefSeqi
WP_003519027.1, NZ_SBHL01000029.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80993 Genomic DNA Translation: CAA56918.2
PIRiS47466
RefSeqiWP_003519027.1, NZ_SBHL01000029.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RQ5X-ray2.40A208-817[»]
2YLKX-ray2.20A/B/C/D1004-1147[»]
3ZQXX-ray1.04A1004-1148[»]
4C8XX-ray2.00A/B/C/D1004-1147[»]
SMRiQ59325
ModBaseiSearch...
PDBe-KBiSearch...

Chemistry databases

DrugBankiDB02717 Cellotetraose

Protein family/group databases

CAZyiCBM3 Carbohydrate-Binding Module Family 3
CBM4 Carbohydrate-Binding Module Family 4
GH9 Glycoside Hydrolase Family 9

Phylogenomic databases

eggNOGiENOG4105E08 Bacteria
COG2730 LUCA
COG3979 LUCA

Enzyme and pathway databases

BioCyciCTHE637887:G1GQP-1842-MONOMER
GCF_001692755:G1EZZ-1840-MONOMER
BRENDAi3.2.1.91 1530

Miscellaneous databases

EvolutionaryTraceiQ59325

Family and domain databases

CDDicd02850 E_set_Cellulase_N, 1 hit
Gene3Di1.10.1330.10, 1 hit
1.50.10.10, 1 hit
2.60.120.260, 1 hit
2.60.40.10, 3 hits
2.60.40.710, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR004197 Cellulase_Ig-like
IPR003305 CenC_carb-bd
IPR002105 Dockerin_1_rpt
IPR016134 Dockerin_dom
IPR036439 Dockerin_dom_sf
IPR018247 EF_Hand_1_Ca_BS
IPR008979 Galactose-bd-like_sf
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR018221 Glyco_hydro_9_His_AS
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF00942 CBM_3, 1 hit
PF02018 CBM_4_9, 1 hit
PF02927 CelD_N, 1 hit
PF00404 Dockerin_1, 1 hit
PF00759 Glyco_hydro_9, 1 hit
SMARTiView protein in SMART
SM01067 CBM_3, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF49384 SSF49384, 1 hit
SSF49785 SSF49785, 1 hit
SSF63446 SSF63446, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51172 CBM3, 1 hit
PS00448 CLOS_CELLULOSOME_RPT, 1 hit
PS51766 DOCKERIN, 1 hit
PS00018 EF_HAND_1, 1 hit
PS00592 GH9_2, 1 hit
PS00698 GH9_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59325_HUNTH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59325
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 11, 2016
Last modified: April 22, 2020
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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