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Protein

60 kDa chaperonin

Gene

groL

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Heat shock protein 60
Short name:
HSP60
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:TC_0386
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000633272 – 54460 kDa chaperoninAdd BLAST543

Proteomic databases

PRIDEiQ59322

Expressioni

Inductioni

By stress.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi243161.CmurN_010100001933

Structurei

3D structure databases

ProteinModelPortaliQ59322
SMRiQ59322
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9 Bacteria
COG0459 LUCA
KOiK04077
OMAiTDTDKME

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAKNIKYNE EARKKIQKGV KTLAEAVKVT LGPKGRHVVI DKSFGSPQVT
60 70 80 90 100
KDGVTVAKEV ELADKHENMG AQMVKEVASK TADKAGDGTT TATVLAEAIY
110 120 130 140 150
TEGLRNVTAG ANPMDLKRGI DKAVKVVVDQ IKKISKPVQH HKEIAQVATI
160 170 180 190 200
SANNDAEIGN LIAEAMEKVG KNGSITVEEA KGFETVLDVV EGMNFNRGYL
210 220 230 240 250
SSYFATNPET QECVLEDALV LIYDKKISGI KDFLPVLQQV AESGRPLLII
260 270 280 290 300
AEDIEGEALA TLVVNRIRGG FRVCAVKAPG FGDRRKAMLE DIAILTGGQL
310 320 330 340 350
ISEELGMKLE NASLAMLGKA KKVIVSKEDT TIVEGMGEKE ALDARCESIK
360 370 380 390 400
KQIEDSTSDY DKEKLQERLA KLSGGVAVIR VGAATEIEMK EKKDRVDDAQ
410 420 430 440 450
HATIAAVEEG ILPGGGTALI RCIPTLEAFL PMLTNEDERI GARIVLKALS
460 470 480 490 500
APLKQIAANA GKEGAIIFQQ VMSRSANEGY DALRDAYTDM IEAGILDPAK
510 520 530 540
VTRSALESAA SVAGLLLTTE ALIAEIPEEK PAAAPAMPGA GMDY
Length:544
Mass (Da):58,106
Last modified:January 23, 2007 - v3
Checksum:i3C7660523E0B2701
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti387I → N in AAA19871 (PubMed:7909303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12004 Genomic DNA Translation: AAA19871.1
U52049 Genomic DNA Translation: AAA97911.1
AE002160 Genomic DNA Translation: AAF39243.1
PIRiD81709
I40731
RefSeqiWP_010230304.1, NZ_CP027217.1

Genome annotation databases

EnsemblBacteriaiAAF39243; AAF39243; TC_0386
GeneIDi1245738
KEGGicmu:TC_0386

Similar proteinsi

Entry informationi

Entry nameiCH60_CHLMU
AccessioniPrimary (citable) accession number: Q59322
Secondary accession number(s): P56837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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