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Entry version 101 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Cellulose synthase 2

Gene

acsAII

Organism
Komagataeibacter hansenii (Gluconacetobacter hansenii)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

It is not essential for cellulose production in this strain.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei187Sequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei234SubstrateSequence analysis1
Binding sitei236SubstrateSequence analysis1
Active sitei331Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCellulose biosynthesis

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT2, Glycosyltransferase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cellulose synthase 2
Including the following 2 domains:
Cellulose synthase catalytic subunit [UDP-forming] (EC:2.4.1.12)
Cyclic di-GMP-binding domain
Alternative name(s):
Cellulose synthase 2 regulatory domain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:acsAII
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKomagataeibacter hansenii (Gluconacetobacter hansenii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri436 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Transmembranei505 – 525HelicalSequence analysisAdd BLAST21
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Transmembranei1553 – 1573HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000592611 – 1596Cellulose synthase 2Add BLAST1596

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini570 – 669PilZAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 749CatalyticAdd BLAST749
Regioni145 – 238Catalytic subdomain AAdd BLAST94
Regioni315 – 375Catalytic subdomain BAdd BLAST61
Regioni750 – 1596Cyclic di-GMP bindingSequence analysisAdd BLAST847
Regioni769 – 812DisorderedSequence analysisAdd BLAST44
Regioni828 – 868DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi784 – 807Pro residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

There are two conserved domains in the globular part of the catalytic subunit: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 2 family.Curated
In the C-terminal section; belongs to the AcsB/BcsB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 2 hits
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003919, Cell_synth_A
IPR003920, Cell_synth_B
IPR018513, Cell_synthase_bac
IPR005150, Cellulose_synth
IPR008979, Galactose-bd-like_sf
IPR001173, Glyco_trans_2-like
IPR029044, Nucleotide-diphossugar_trans
IPR009875, PilZ_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03170, BcsB, 1 hit
PF03552, Cellulose_synt, 1 hit
PF00535, Glycos_transf_2, 1 hit
PF07238, PilZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01440, CELLSNTHASEB

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448, SSF53448, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03030, CelA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q59167-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIYRAILKRL RLEQLARVPA VSAASPFVMM AVGVFLMLMA GGVTISTTSQ
60 70 80 90 100
AFVTCGTVGL FLLLKGRKGR GVTCFLMMLS LLVSLRYMVW RLTTTLELHS
110 120 130 140 150
PLQAALSLLL VAAELYALLT LCLSYFQMSW PLDRKPLPLP ADTTDWPVVD
160 170 180 190 200
VYVPSYNEEL SLVRSTVLGA LAIDWPADKL NVYILDDGRR KSFHAFAMEA
210 220 230 240 250
GAGYIIRDQN NHAKAGNLNH ALRVTEGEYV VIFDCDHIPT RGFLKKTIGW
260 270 280 290 300
MMADPKLALL QTPHHFYSPD PFQRNLATGQ NVPPEGNMFY GLVQDGNDFW
310 320 330 340 350
DATFFCGSCA AIRRSAVLGI GGFATETVTE DAHTALKMQR EGWHTAYLRQ
360 370 380 390 400
PLAAGLSTER LMLHIGQRVR WARGMLQIMR LDNPLLGSGL RWQQRLCYLS
410 420 430 440 450
AMSHFLFAIP RLVFLASPLA FLFLGQNIIA ASPFAILVYA FPHVFHSIGT
460 470 480 490 500
LSRVEGRWRY SFWSEIYETT LALFLVRVTI MTLLNPRKGE FNVTDKGGLL
510 520 530 540 550
QSEYFDLNAV YPNVILAVIL ALALVRGIGG MMWEYHDRLA LQSFALNTLW
560 570 580 590 600
VAVSLIIVLA SIAVGRETRQ IRHKPRVRAT LPITLIDEHG QHYHAHTSDI
610 620 630 640 650
SLGGIAARLS TEHALPTQTR VTMLYHNEKD GIDVRIPAVI LFSKPGQLHL
660 670 680 690 700
QWSVDDLDVE RQIVEFMFGR NDAWSNWGDF QPDRPVRSFL MVLRSIGGLF
710 720 730 740 750
RRGQRLFRWQ APQEAPLAES EHVEEEKLEK KSLVLKPVRR SARHGATASL
760 770 780 790 800
IVLLGLPAAI APSLAQAPSR ATPVATEQGA TPVEPPPVNA PPPPSLPQPP
810 820 830 840 850
GTLPTPPQIA PASAGELLPA ATAVSLPTGP ATQQMRERLS ERTGVSPASP
860 870 880 890 900
FGDTNTGALP ADPSAPPIDP ADAARVADGE ITRTSTFRDL GLATGPLTLR
910 920 930 940 950
GFSPLQGLDV IVPANRVVTR ARITLSGALS PSLLPEASAV SVTLNEQYVG
960 970 980 990 1000
TIRVDPEHPR FGPITFDIDP LYFTGDNKLN FHFAGEYRRD CNDLYNEVLW
1010 1020 1030 1040 1050
ARISDFSTVT LTTTRIAPDR KLSYLPAPFY DPNLRTPLRV PVVMPNPDAH
1060 1070 1080 1090 1100
GMLKASALVA SWFGKLADFR KVSFPVSTTI PASGNAIAIG ENLPIDARGT
1110 1120 1130 1140 1150
RPTGPTLSEV ENPNDRLGTI LVLTGRNAQE VEVAARVLAF SSDTLGAVGT
1160 1170 1180 1190 1200
KVVNDVTLQP RHPYDAPAFV PTDRPVRFGE LVAASDLQGG GFAPPVMALP
1210 1220 1230 1240 1250
FHLPPDLYSW RNRPYPIDLW VRTPGGPVVD LETSRLDVHL NNNYLDSFTL
1260 1270 1280 1290 1300
KPPSLWAAWS ERLVNQHAGA VEHAAALPPW LLFGQNQLKF SFDARPIDRG
1310 1320 1330 1340 1350
VCRRTPDDIH MSVDSDSWLD FRRGYHFARL PNLSYFAEAA FPFSRMADLS
1360 1370 1380 1390 1400
ETTVVVPHHI DAGTAGTFMD LMGFFGATTW YPASGVQVAD INDLSEHPPQ
1410 1420 1430 1440 1450
GDILILATAG DAPKFEELLT RAPYELTDGH IRVGQHMGLQ GIWYLFQDHD
1460 1470 1480 1490 1500
HAGLQDGVQA NLNAPIAGAG VLLGAQSPYR SDRSVVALMG DTPSRMHDLV
1510 1520 1530 1540 1550
MGLRSKEDVP RIQGDLVLRN GDRLTSYRTA PTFTMGSLPW WMWLDWYLGT
1560 1570 1580 1590
RPLTLYVLGL VGAGLVAAAA VRLLRRRAQH RLEEAARVKD TTDASH
Length:1,596
Mass (Da):175,801
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD98A6F6259E1F3CE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U15957 Genomic DNA Translation: AAA85264.1

Protein sequence database of the Protein Information Resource

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PIRi
T31338

NCBI Reference Sequences

More...
RefSeqi
WP_003621570.1, NZ_LUCI01000092.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15957 Genomic DNA Translation: AAA85264.1
PIRiT31338
RefSeqiWP_003621570.1, NZ_LUCI01000092.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiGT2, Glycosyltransferase Family 2

Family and domain databases

Gene3Di2.60.120.260, 2 hits
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR003919, Cell_synth_A
IPR003920, Cell_synth_B
IPR018513, Cell_synthase_bac
IPR005150, Cellulose_synth
IPR008979, Galactose-bd-like_sf
IPR001173, Glyco_trans_2-like
IPR029044, Nucleotide-diphossugar_trans
IPR009875, PilZ_domain
PfamiView protein in Pfam
PF03170, BcsB, 1 hit
PF03552, Cellulose_synt, 1 hit
PF00535, Glycos_transf_2, 1 hit
PF07238, PilZ, 1 hit
PRINTSiPR01440, CELLSNTHASEB
SUPFAMiSSF53448, SSF53448, 1 hit
TIGRFAMsiTIGR03030, CelA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACSA2_KOMHA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59167
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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