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UniProtKB - Q59121 (PLD_ARCHD)
Protein
Phospholipase D
Gene
pld
Organism
Arcanobacterium haemolyticum (strain ATCC 9345 / DSM 20595 / CCUG 17215 / LMG 16163 / NBRC 15585 / NCTC 8452 / 11018)
Status
Functioni
Virulence factor affecting bacterial dissemination and survival within the host. Has magnesium-dependent catalytic activity toward sphingomyelin (SM) and acyl- and alkyl-lysophosphatidylcholine (LPC), but not toward sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC). Lysophosphatidic acid (LPA), assumed to result from LPC hydrolysis, evokes pathophysiological responses after LPA receptor internalization. Shows hemolytic activity.
By similarityCatalytic activityi
- EC:3.1.4.41By similarity
- 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H+By similarity
Cofactori
Mg2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 46 | Sequence analysis | 1 |
GO - Molecular functioni
- sphingomyelin phosphodiesterase D activity Source: UniProtKB-EC
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism, Virulence |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pld Ordered Locus Names:Arch_1099 |
Organismi | Arcanobacterium haemolyticum (strain ATCC 9345 / DSM 20595 / CCUG 17215 / LMG 16163 / NBRC 15585 / NCTC 8452 / 11018) |
Taxonomic identifieri | 644284 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Actinomycetales › Actinomycetaceae › Arcanobacterium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | By similarityAdd BLAST | 26 | |
ChainiPRO_0000022065 | 27 – 309 | Phospholipase DAdd BLAST | 283 |
Structurei
3D structure databases
AlphaFoldDBi | Q59121 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the sphingomyelinase D/phospholipase D family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502ZB0H, Bacteria |
HOGENOMi | CLU_059400_0_0_11 |
OMAi | WLDLKNP |
OrthoDBi | 697975at2 |
Family and domain databases
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR017946, PLC-like_Pdiesterase_TIM-brl IPR016674, SMase_D/PLipase_D |
PIRSFi | PIRSF016632, Phospholipase_actinobac/fun, 1 hit |
SUPFAMi | SSF51695, SSF51695, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q59121-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTRKKIALA LSLLTGFMLP IGSAAAAPLA QEQPTTGNRP VYAIAHRVLT
60 70 80 90 100
KQSVDDAIKI GANALEIDFT AWRRGWWADH DGLPTSAGDT AEDILKYIAQ
110 120 130 140 150
KRREGNNITF VWFDIKNPDY CKDQNSVCSI TKLRDLARQT IEQEGVRALF
160 170 180 190 200
GFYKTVGGVG WNTIANNLND KEAVALSGRK DDIMKDFKQY ENKIKPQQRV
210 220 230 240 250
ADNGYYNLSY GFGGCYRDEN QTCDQLRLAG EERKKGNLGK TFGWTVSTGQ
260 270 280 290 300
EYLAADLLNK AEVDGMIFGF KTTYFYDHAD TRNAFAGIKN WVDAHQGTHH
MATNKDIPW
Sequence cautioni
The sequence AAA21882 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence ADH92813 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L16583 Genomic DNA Translation: AAA21882.1 Different initiation. CP002045 Genomic DNA Translation: ADH92813.1 Different initiation. |
PIRi | I39484 |
RefSeqi | WP_041640381.1, NC_014218.1 |
Genome annotation databases
EnsemblBacteriai | ADH92813; ADH92813; Arch_1099 |
KEGGi | ahe:Arch_1099 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L16583 Genomic DNA Translation: AAA21882.1 Different initiation. CP002045 Genomic DNA Translation: ADH92813.1 Different initiation. |
PIRi | I39484 |
RefSeqi | WP_041640381.1, NC_014218.1 |
3D structure databases
AlphaFoldDBi | Q59121 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
EnsemblBacteriai | ADH92813; ADH92813; Arch_1099 |
KEGGi | ahe:Arch_1099 |
Phylogenomic databases
eggNOGi | ENOG502ZB0H, Bacteria |
HOGENOMi | CLU_059400_0_0_11 |
OMAi | WLDLKNP |
OrthoDBi | 697975at2 |
Family and domain databases
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR017946, PLC-like_Pdiesterase_TIM-brl IPR016674, SMase_D/PLipase_D |
PIRSFi | PIRSF016632, Phospholipase_actinobac/fun, 1 hit |
SUPFAMi | SSF51695, SSF51695, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLD_ARCHD | |
Accessioni | Q59121Primary (citable) accession number: Q59121 Secondary accession number(s): D7BPG4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 81 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families