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UniProtKB - Q59112 (GCTB_ACIFV)
Protein
Glutaconate CoA-transferase subunit B
Gene
gctB
Organism
Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4)
Status
Functioni
Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate.
Catalytic activityi
- EC:2.8.3.12
: L-glutamate degradation via hydroxyglutarate pathway Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes crotonoyl-CoA from L-glutamate. This subpathway is part of the pathway L-glutamate degradation via hydroxyglutarate pathway, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes crotonoyl-CoA from L-glutamate, the pathway L-glutamate degradation via hydroxyglutarate pathway and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 54 | 1 |
GO - Molecular functioni
- glutaconate CoA-transferase activity Source: UniProtKB-EC
GO - Biological processi
- glutamate catabolic process via 2-hydroxyglutarate Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
BRENDAi | 2.8.3.12, 85 |
SABIO-RKi | Q59112 |
UniPathwayi | UPA00533;UER00686 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutaconate CoA-transferase subunit B (EC:2.8.3.12)Alternative name(s): GCT small subunit |
Gene namesi | Name:gctB Ordered Locus Names:Acfer_1818 |
Organismi | Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4) |
Taxonomic identifieri | 591001 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Negativicutes › Acidaminococcales › Acidaminococcaceae › Acidaminococcus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000157930 | 2 – 266 | Glutaconate CoA-transferase subunit BAdd BLAST | 265 |
Interactioni
Subunit structurei
Heterooctamer of four A and four B subunits.
Protein-protein interaction databases
DIPi | DIP-6201N |
IntActi | Q59112, 1 interactor |
STRINGi | 591001.Acfer_1818 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q59112 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q59112 |
Family & Domainsi
Sequence similaritiesi
Belongs to the 3-oxoacid CoA-transferase subunit B family.Curated
Phylogenomic databases
eggNOGi | COG2057, Bacteria |
HOGENOMi | CLU_069088_0_0_9 |
OMAi | YWVGNHS |
OrthoDBi | 1380130at2 |
Family and domain databases
InterProi | View protein in InterPro IPR004165, CoA_trans_fam_I IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01144, CoA_trans, 1 hit |
SMARTi | View protein in SMART SM00882, CoA_trans, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q59112-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADYTNYTNK EMQAVTIAKQ IKNGQVVTVG TGLPLIGASV AKRVYAPDCH
60 70 80 90 100
IIVESGLMDC SPVEVPRSVG DLRFMAHCGC IWPNVRFVGF EINEYLHKAN
110 120 130 140 150
RLIAFIGGAQ IDPYGNVNST SIGDYHHPKT RFTGSGGANG IATYSNTIIM
160 170 180 190 200
MQHEKRRFMN KIDYVTSPGW IDGPGGRERL GLPGDVGPQL VVTDKGILKF
210 220 230 240 250
DEKTKRMYLA AYYPTSSPED VLENTGFDLD VSKAVELEAP DPAVIKLIRE
260
EIDPGQAFIQ VPTEAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81440 Genomic DNA Translation: CAA57200.1 CP001859 Genomic DNA Translation: ADB48172.1 |
PIRi | S51052 |
RefSeqi | WP_012939155.1, NC_013740.1 |
Genome annotation databases
EnsemblBacteriai | ADB48172; ADB48172; Acfer_1818 |
KEGGi | afn:Acfer_1818 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81440 Genomic DNA Translation: CAA57200.1 CP001859 Genomic DNA Translation: ADB48172.1 |
PIRi | S51052 |
RefSeqi | WP_012939155.1, NC_013740.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1POI | X-ray | 2.50 | B/D | 3-262 | [»] | |
SMRi | Q59112 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-6201N |
IntActi | Q59112, 1 interactor |
STRINGi | 591001.Acfer_1818 |
Genome annotation databases
EnsemblBacteriai | ADB48172; ADB48172; Acfer_1818 |
KEGGi | afn:Acfer_1818 |
Phylogenomic databases
eggNOGi | COG2057, Bacteria |
HOGENOMi | CLU_069088_0_0_9 |
OMAi | YWVGNHS |
OrthoDBi | 1380130at2 |
Enzyme and pathway databases
UniPathwayi | UPA00533;UER00686 |
BRENDAi | 2.8.3.12, 85 |
SABIO-RKi | Q59112 |
Miscellaneous databases
EvolutionaryTracei | Q59112 |
Family and domain databases
InterProi | View protein in InterPro IPR004165, CoA_trans_fam_I IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01144, CoA_trans, 1 hit |
SMARTi | View protein in SMART SM00882, CoA_trans, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GCTB_ACIFV | |
Accessioni | Q59112Primary (citable) accession number: Q59112 Secondary accession number(s): D2RM70 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families