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Protein

Pyruvate dehydrogenase E1 component

Gene

pdhA

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:pdhA
Ordered Locus Names:H16_A1374
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000008210 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622381 – 895Pyruvate dehydrogenase E1 componentAdd BLAST895

Proteomic databases

PRIDEiQ59097

Interactioni

Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

Protein-protein interaction databases

STRINGi381666.H16_A1374

Structurei

3D structure databases

ProteinModelPortaliQ59097
SMRiQ59097
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105DAQ Bacteria
COG2609 LUCA
HOGENOMiHOG000115215
KOiK00163
OMAiREPWFPG

Family and domain databases

CDDicd02017 TPP_E1_EcPDC_like, 1 hit
Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR004660 2-oxoA_DH_E1
IPR035807 PDC_E1_N
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005474 Transketolase_N
PANTHERiPTHR43825:SF3 PTHR43825:SF3, 1 hit
PfamiView protein in Pfam
PF00456 Transketolase_N, 1 hit
PIRSFiPIRSF000156 Pyruvate_dh_E1, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00759 aceE, 1 hit

Sequencei

Sequence statusi: Complete.

Q59097-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAVPEQILG ASSANDADPQ ETHEWLDALQ GVLAAEGPAR AAFLIDKQIE
60 70 80 90 100
YARVNGVTQP FHAETQYINT IPVEQQARIP GDQDIEHRIR SYTRWNAMAM
110 120 130 140 150
VLRANKHTNV GGHISSFASA ATLYDVGYNH FWRAPSEAGG GDLVFVQGHS
160 170 180 190 200
APGVYSRAFL LGRLTQDQLD NFRQEVDGKG ISSYPHPWLM PDFWQFPTVS
210 220 230 240 250
MGLGPIMAIY QARFMKYLDS RGLAKAGDRK VWAFLGDGET DEPESLGAIG
260 270 280 290 300
MAGREKLDNL VFVINCNLQR LDGPVRGNGK IIQELESEFR GAGWNVIKVV
310 320 330 340 350
WGSKWDSLLA RDTKGLLMKR MMECVDGEYQ TMKAKDGAYV REHFFNTPEL
360 370 380 390 400
KAMVADWSDD DIWRLNRGGH DPHKIYAAYK AASEHKGQPT LILAKTIKGY
410 420 430 440 450
GMGDAGQAMN VAHQQKKMPV DAIRKFRDQF NLPVADDQLE EVPYITFPEG
460 470 480 490 500
SKELEYMRQA RQNLGGYLPA RRQKAEALPV PQLSAFDALL KATGEGREVS
510 520 530 540 550
TTMAFVRILN TLLKDKQIGK HVVPIVPDES RTFGMEGLFR QVGIWNQEGQ
560 570 580 590 600
KYVPEDHDQL MFYKESQTGQ VLQEGINEAG AMCDWIAAAT SYSTHGVQMI
610 620 630 640 650
PFYIYYSMFG IQRIGDLCWA AADMRSRGFL LGGTAGRTTL NGEGLQHEDG
660 670 680 690 700
HSHVFHAAIP NCISYDPTFQ YELAVVMQDG LRRMYAEQED VYYYLTVMNE
710 720 730 740 750
NYEHPEMPAG VEQDIVKGMY QFRKGVENSN APRVQLLGSG TIFREVIAAA
760 770 780 790 800
DLLKKDWGVE SDLWGCPSFT ELAREGHDVE RFNLLHPTET PRESHVAKSL
810 820 830 840 850
KSARGPVIAS TDYVRAFAEQ IRPFVPRRYV VLGTDGFGRS DTREKLRHFF
860 870 880 890
EVDRYWVTLA ALKALADEGA IGRDKVAEAI KKYNLDPNKP NPMSV
Length:895
Mass (Da):100,365
Last modified:November 1, 1996 - v1
Checksum:i522A9A3C43454051
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09865 Genomic DNA Translation: AAA21598.1
AM260479 Genomic DNA Translation: CAJ92510.1
PIRiA55514
RefSeqiWP_011615027.1, NC_008313.1

Genome annotation databases

EnsemblBacteriaiCAJ92510; CAJ92510; H16_A1374
KEGGireh:H16_A1374
PATRICifig|381666.6.peg.1763

Similar proteinsi

Entry informationi

Entry nameiODP1_CUPNH
AccessioniPrimary (citable) accession number: Q59097
Secondary accession number(s): Q0KBW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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