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Entry version 110 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation EC:3.1.11.1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Multifunctional enzyme, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase II large subunit (EC:2.7.7.7UniRule annotation)
Short name:
Pol II
Alternative name(s):
Exodeoxyribonuclease large subunitUniRule annotation (EC:3.1.11.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polC
Ordered Locus Names:MJ1630
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243232 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001525751 – 1139DNA polymerase II large subunitAdd BLAST1139

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q59024

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a large subunit and a small subunit.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
243232.MJ_1630

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q59024

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG04447, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001154_0_0_2

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q59024

Identification of Orthologs from Complete Genome Data

More...
OMAi
KRRNCDG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q59024

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00324, DNApol_II_L_arch, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004475, PolC_DP2
IPR016033, PolC_DP2_N

The PANTHER Classification System

More...
PANTHERi
PTHR42210, PTHR42210, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03833, PolC_DP2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016275, PolC_DP2, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00354, polC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q59024-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVMVHVACS ENMKKYFENI VDEVKKIYRI AEECRKKGFD PTDEVEIPLA
60 70 80 90 100
ADMADRVEGL VGPKGVAERI RELVKELGKE PAALEIAKEI VEGKFGNFDK
110 120 130 140 150
EKKAEQAVRT ALAVLTEGIV AAPLEGIADV KIKKNPDGTE YLAIYYAGPI
160 170 180 190 200
RSAGGTAQAL SVLVGDFVRK AMGLDRYKPT EDEIERYVEE VELYQSEVGS
210 220 230 240 250
FQYNPTADEI RTAIRNIPIE ITGEATDDVE VSGHRDLPRV ETNQLRGGAL
260 270 280 290 300
LVLVEGVLLK APKILRHVDK LGIEGWDWLK DLMSKKEEKE EEKDEKVDDE
310 320 330 340 350
EIDEEEEEIS GYWRDVKIEA NKKFISEVIA GRPVFAHPSK VGGFRLRYGR
360 370 380 390 400
SRNTGFATQG FHPALMYLVD EFMAVGTQLK TERPGKATCV VPVDSIEPPI
410 420 430 440 450
VKLKNGDVIR VDTIEKAMDV RNRVEEILFL GDVLVNYGDF LENNHPLLPS
460 470 480 490 500
CWCEEWYEKI LIANNIEYDK DFIKNPKPEE AVKFALETKT PLHPRFTYHW
510 520 530 540 550
HDVSKEDIIL LRNWLLKGKE DSLEGKKVWI VDLEIEEDKK AKRILELIGC
560 570 580 590 600
CHLVRNKKVI IEEYYPLLYS LGFDVENKKD LVENIEKILE SAKNSMHLIN
610 620 630 640 650
LLAPFEVRRN TYVYVGARMG RPEKAAPRKM KPPVNGLFPI GNAGGQVRLI
660 670 680 690 700
NKAVEENNTD DVDVSYTRCP NCGKISLYRV CPFCGTKVEL DNFGRIKAPL
710 720 730 740 750
KDYWYAALKR LGINKPGDVK CIKGMTSKQK IVEPLEKAIL RAINEVYVFK
760 770 780 790 800
DGTTRFDCTD VPVTHFKPNE INVTVEKLRE LGYDKDIYGN ELVDGEQVVE
810 820 830 840 850
LKPQDVIIPE SCAEYFVKVA NFIDDLLEKF YKVERFYNVK KKEDLIGHLV
860 870 880 890 900
IGMAPHTSAG MVGRIIGYTK ANVGYAHPYF HAAKRRNCDG DEDSFFLLLD
910 920 930 940 950
AFLNFSKKFL PDKRGGQMDA PLVLTTILDP KEVDGEVHNM DTMWSYPLEF
960 970 980 990 1000
YEKTLEMPSP KEVKEFMETV EDRLGKPEQY EGIGYTHETS RIDLGPKVCA
1010 1020 1030 1040 1050
YKTLGSMLEK TTSQLSVAKK IRATDERDVA EKVIQSHFIP DLIGNLRAFS
1060 1070 1080 1090 1100
RQAVRCKCGA KYRRIPLKGK CPKCGSNLIL TVSKGAVEKY MDVAEKMAEE
1110 1120 1130
YNVNDYIKQR LKIIKEGINS IFENEKSRQV KLSDFFKIG
Length:1,139
Mass (Da):129,402
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B7968A013AAC45A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99651.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D64503

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAB99651; AAB99651; MJ_1630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mja:MJ_1630

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99651.1
PIRiD64503

3D structure databases

SMRiQ59024
ModBaseiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1630

Proteomic databases

PRIDEiQ59024

Genome annotation databases

EnsemblBacteriaiAAB99651; AAB99651; MJ_1630
KEGGimja:MJ_1630

Phylogenomic databases

eggNOGiarCOG04447, Archaea
HOGENOMiCLU_001154_0_0_2
InParanoidiQ59024
OMAiKRRNCDG
PhylomeDBiQ59024

Family and domain databases

HAMAPiMF_00324, DNApol_II_L_arch, 1 hit
InterProiView protein in InterPro
IPR004475, PolC_DP2
IPR016033, PolC_DP2_N
PANTHERiPTHR42210, PTHR42210, 1 hit
PfamiView protein in Pfam
PF03833, PolC_DP2, 1 hit
PIRSFiPIRSF016275, PolC_DP2, 1 hit
TIGRFAMsiTIGR00354, polC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDP2L_METJA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59024
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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