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Protein

DDB1- and CUL4-associated factor 6

Gene

DCAF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.3 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • nuclear receptor transcription coactivator activity Source: MGI

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: MGI
  • post-translational protein modification Source: Reactome
  • protein ubiquitination Source: UniProtKB-UniPathway

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
SignaLinkiQ58WW2
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 6
Alternative name(s):
Androgen receptor complex-associated protein
Short name:
ARCAP
IQ motif and WD repeat-containing protein 1
Nuclear receptor interaction protein
Short name:
NRIP
Gene namesi
Name:DCAF6
Synonyms:IQWD1
ORF Names:MSTP055
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143164.15
HGNCiHGNC:30002 DCAF6
MIMi610494 gene
neXtProtiNX_Q58WW2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55827
OpenTargetsiENSG00000143164
PharmGKBiPA165751150

Polymorphism and mutation databases

BioMutaiDCAF6
DMDMi74755134

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003044011 – 860DDB1- and CUL4-associated factor 6Add BLAST860

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei654PhosphothreonineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei847PhosphoserineBy similarity1
Modified residuei850PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ58WW2
MaxQBiQ58WW2
PaxDbiQ58WW2
PeptideAtlasiQ58WW2
PRIDEiQ58WW2
ProteomicsDBi62628
62629 [Q58WW2-2]
62630 [Q58WW2-3]
62631 [Q58WW2-4]

PTM databases

iPTMnetiQ58WW2
PhosphoSitePlusiQ58WW2

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland.1 Publication

Gene expression databases

BgeeiENSG00000143164 Expressed in 226 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_IQWD1
ExpressionAtlasiQ58WW2 baseline and differential
GenevisibleiQ58WW2 HS

Organism-specific databases

HPAiHPA054305

Interactioni

Subunit structurei

Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GTF2IRD1Q9UHL92EBI-2559044,EBI-372530

Protein-protein interaction databases

BioGridi120933, 52 interactors
DIPiDIP-44678N
IntActiQ58WW2, 15 interactors
MINTiQ58WW2
STRINGi9606.ENSP00000356814

Structurei

Secondary structure

1860
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ58WW2
SMRiQ58WW2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58WW2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 88WD 1Add BLAST40
Repeati92 – 133WD 2Add BLAST42
Repeati139 – 179WD 3Add BLAST41
Repeati189 – 229WD 4Add BLAST41
Repeati251 – 290WD 5Add BLAST40
Domaini676 – 705IQPROSITE-ProRule annotationAdd BLAST30
Repeati718 – 756WD 6Add BLAST39
Repeati759 – 798WD 7Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1310 Eukaryota
KOG1334 Eukaryota
ENOG410XQZP LUCA
GeneTreeiENSGT00530000062951
HOGENOMiHOG000038027
HOVERGENiHBG054871
InParanoidiQ58WW2
KOiK11795
OMAiRDNGHIT
OrthoDBiEOG091G01Z0
PhylomeDBiQ58WW2
TreeFamiTF326071

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q58WW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRGGSYPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH
60 70 80 90 100
DGCVNTICWN DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA
110 120 130 140 150
KFLPCTNDKQ IVSCSGDGVI FYTNVEQDAE TNRQCQFTCH YGTTYEIMTV
160 170 180 190 200
PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE DCKDDILINC RRAATSVAIC
210 220 230 240 250
PPIPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM VARFIPSHLN
260 270 280 290 300
NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE
310 320 330 340 350
ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS
360 370 380 390 400
RWFEEASEVA QSNRGRGRSR PRGGTSQSDI STLPTVPSSP DLEVSETAME
410 420 430 440 450
VDTPAEQFLQ PSTSSTMSAQ AHSTSSPTES PHSTPLLSSP DSEQRQSVEA
460 470 480 490 500
SGHHTHHQSD NNNEKLSPKP GTGEPVLSLH YSTEGTTTST IKLNFTDEWS
510 520 530 540 550
SIASSSRGIG SHCKSEGQEE SFVPQSSVQP PEGDSETKAP EESSEDVTKY
560 570 580 590 600
QEGVSAENPV ENHINITQSD KFTAKPLDSN SGERNDLNLD RSCGVPEESA
610 620 630 640 650
SSEKAKEPET SDQTSTESAT NENNTNPEPQ FQTEATGPSA HEETSTRDSA
660 670 680 690 700
LQDTDDSDDD PVLIPGARYR AGPGDRRSAV ARIQEFFRRR KERKEMEELD
710 720 730 740 750
TLNIRRPLVK MVYKGHRNSR TMIKEANFWG ANFVMSGSDC GHIFIWDRHT
760 770 780 790 800
AEHLMLLEAD NHVVNCLQPH PFDPILASSG IDYDIKIWSP LEESRIFNRK
810 820 830 840 850
LADEVITRNE LMLEETRNTI TVPASFMLRM LASLNHIRAD RLEGDRSEGS
860
GQENENEDEE
Length:860
Mass (Da):96,292
Last modified:April 26, 2005 - v1
Checksum:i8C7602D635DAF124
GO
Isoform 2 (identifier: Q58WW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: S → SDSPSSVVNKQLGSMSLDEQQ

Note: No experimental confirmation available.
Show »
Length:880
Mass (Da):98,423
Checksum:i3CB84C1FBB647E0D
GO
Isoform 3 (identifier: Q58WW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: S → SEFLRGPEIA...LGSMSLDEQQ
     675-675: D → DRFNIRGTTIGDRIM

Show »
Length:951
Mass (Da):106,542
Checksum:iA60EC942B9C5035A
GO
Isoform 4 (identifier: Q58WW2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-84: Missing.
     459-459: S → SEFLRGPEIA...LGSMSLDEQQ
     675-675: D → DRFNIRGTTIGDRIM

Note: No experimental confirmation available.
Show »
Length:920
Mass (Da):103,070
Checksum:i30564F36EFA28122
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z305F2Z305_HUMAN
DDB1- and CUL4-associated factor 6
DCAF6
472Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035020547V → A1 PublicationCorresponds to variant dbSNP:rs11558511Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04331254 – 84Missing in isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_028019459S → SDSPSSVVNKQLGSMSLDEQ Q in isoform 2. 1 Publication1
Alternative sequenceiVSP_028020459S → SEFLRGPEIALLRKRLQQLR LKKAEQQRQQELAAHTQQQP STSDQSSHEGSSQDPHASDS PSSVVNKQLGSMSLDEQQ in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_028021675D → DRFNIRGTTIGDRIM in isoform 3 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY766164 mRNA Translation: AAX09330.1
DQ768089 mRNA Translation: ABG76793.1
AF116725 mRNA Translation: AAO15301.1
AK297847 mRNA Translation: BAG60180.1
Z97876 Genomic DNA No translation available.
AL033531 Genomic DNA No translation available.
AL031287 Genomic DNA No translation available.
AL033532 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90809.1
BC025262 mRNA Translation: AAH25262.2
AL136738 mRNA Translation: CAB66672.2
CCDSiCCDS1267.2 [Q58WW2-2]
CCDS30933.1 [Q58WW2-1]
CCDS55657.1 [Q58WW2-3]
CCDS55658.1 [Q58WW2-4]
RefSeqiNP_001017977.1, NM_001017977.2 [Q58WW2-1]
NP_001185885.1, NM_001198956.1 [Q58WW2-3]
NP_001185886.1, NM_001198957.1 [Q58WW2-4]
NP_060912.2, NM_018442.3 [Q58WW2-2]
UniGeneiHs.435741

Genome annotation databases

EnsembliENST00000312263; ENSP00000311949; ENSG00000143164 [Q58WW2-1]
ENST00000367840; ENSP00000356814; ENSG00000143164 [Q58WW2-3]
ENST00000367843; ENSP00000356817; ENSG00000143164 [Q58WW2-2]
ENST00000432587; ENSP00000396238; ENSG00000143164 [Q58WW2-4]
GeneIDi55827
KEGGihsa:55827
UCSCiuc001gev.5 human [Q58WW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY766164 mRNA Translation: AAX09330.1
DQ768089 mRNA Translation: ABG76793.1
AF116725 mRNA Translation: AAO15301.1
AK297847 mRNA Translation: BAG60180.1
Z97876 Genomic DNA No translation available.
AL033531 Genomic DNA No translation available.
AL031287 Genomic DNA No translation available.
AL033532 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90809.1
BC025262 mRNA Translation: AAH25262.2
AL136738 mRNA Translation: CAB66672.2
CCDSiCCDS1267.2 [Q58WW2-2]
CCDS30933.1 [Q58WW2-1]
CCDS55657.1 [Q58WW2-3]
CCDS55658.1 [Q58WW2-4]
RefSeqiNP_001017977.1, NM_001017977.2 [Q58WW2-1]
NP_001185885.1, NM_001198956.1 [Q58WW2-3]
NP_001185886.1, NM_001198957.1 [Q58WW2-4]
NP_060912.2, NM_018442.3 [Q58WW2-2]
UniGeneiHs.435741

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I7OX-ray2.80B9-21[»]
ProteinModelPortaliQ58WW2
SMRiQ58WW2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120933, 52 interactors
DIPiDIP-44678N
IntActiQ58WW2, 15 interactors
MINTiQ58WW2
STRINGi9606.ENSP00000356814

PTM databases

iPTMnetiQ58WW2
PhosphoSitePlusiQ58WW2

Polymorphism and mutation databases

BioMutaiDCAF6
DMDMi74755134

Proteomic databases

EPDiQ58WW2
MaxQBiQ58WW2
PaxDbiQ58WW2
PeptideAtlasiQ58WW2
PRIDEiQ58WW2
ProteomicsDBi62628
62629 [Q58WW2-2]
62630 [Q58WW2-3]
62631 [Q58WW2-4]

Protocols and materials databases

DNASUi55827
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312263; ENSP00000311949; ENSG00000143164 [Q58WW2-1]
ENST00000367840; ENSP00000356814; ENSG00000143164 [Q58WW2-3]
ENST00000367843; ENSP00000356817; ENSG00000143164 [Q58WW2-2]
ENST00000432587; ENSP00000396238; ENSG00000143164 [Q58WW2-4]
GeneIDi55827
KEGGihsa:55827
UCSCiuc001gev.5 human [Q58WW2-1]

Organism-specific databases

CTDi55827
DisGeNETi55827
EuPathDBiHostDB:ENSG00000143164.15
GeneCardsiDCAF6
HGNCiHGNC:30002 DCAF6
HPAiHPA054305
MIMi610494 gene
neXtProtiNX_Q58WW2
OpenTargetsiENSG00000143164
PharmGKBiPA165751150
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1310 Eukaryota
KOG1334 Eukaryota
ENOG410XQZP LUCA
GeneTreeiENSGT00530000062951
HOGENOMiHOG000038027
HOVERGENiHBG054871
InParanoidiQ58WW2
KOiK11795
OMAiRDNGHIT
OrthoDBiEOG091G01Z0
PhylomeDBiQ58WW2
TreeFamiTF326071

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
SignaLinkiQ58WW2

Miscellaneous databases

ChiTaRSiDCAF6 human
EvolutionaryTraceiQ58WW2
GenomeRNAii55827
PROiPR:Q58WW2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143164 Expressed in 226 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_IQWD1
ExpressionAtlasiQ58WW2 baseline and differential
GenevisibleiQ58WW2 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDCAF6_HUMAN
AccessioniPrimary (citable) accession number: Q58WW2
Secondary accession number(s): A2A295
, B4DNB8, Q7L8I0, Q8IXH3, Q8TB19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 26, 2005
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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