UniProtKB - Q58FF7 (H90B3_HUMAN)
Protein
Putative heat shock protein HSP 90-beta-3
Gene
HSP90AB3P
Organism
Homo sapiens (Human)
Status
Functioni
Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.By similarity
Caution
Could be the product of a pseudogene.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 46 | ATPBy similarity | 1 | |
Binding sitei | 88 | ATPBy similarity | 1 | |
Binding sitei | 107 | ATPBy similarity | 1 | |
Binding sitei | 334 | ATPBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: GO_Central
- disordered domain specific binding Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- cellular response to heat Source: GO_Central
- protein folding Source: GO_Central
- protein stabilization Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q58FF7 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative heat shock protein HSP 90-beta-3Alternative name(s): Heat shock protein 90-beta c Short name: Heat shock protein 90Bc |
Gene namesi | Name:HSP90AB3P Synonyms:HSP90BC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5259, HSP90AB3P |
neXtProti | NX_Q58FF7 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: GO_Central
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: GO_Central
- protein-containing complex Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Miscellaneous databases
Pharosi | Q58FF7, Tdark |
Polymorphism and mutation databases
BioMutai | HGNC:5259 |
DMDMi | 74722492 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000336047 | 1 – 597 | Putative heat shock protein HSP 90-beta-3Add BLAST | 597 |
Proteomic databases
EPDi | Q58FF7 |
jPOSTi | Q58FF7 |
MassIVEi | Q58FF7 |
MaxQBi | Q58FF7 |
PeptideAtlasi | Q58FF7 |
PRIDEi | Q58FF7 |
ProteomicsDBi | 62622 |
TopDownProteomicsi | Q58FF7 |
PTM databases
GlyConnecti | 1697, 2 N-Linked glycans (2 sites) |
GlyGeni | Q58FF7, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q58FF7 |
PhosphoSitePlusi | Q58FF7 |
SwissPalmi | Q58FF7 |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- disordered domain specific binding Source: GO_Central
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
IntActi | Q58FF7, 58 interactors |
MINTi | Q58FF7 |
Miscellaneous databases
RNActi | Q58FF7, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 414 – 446 | Sequence analysisAdd BLAST | 33 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 593 – 597 | TPR repeat-binding | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 289 – 292 | Poly-Lys | 4 |
Domaini
The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity
Sequence similaritiesi
Belongs to the heat shock protein 90 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
InParanoidi | Q58FF7 |
PhylomeDBi | Q58FF7 |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 2 hits |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 3 hits |
Pfami | View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 2 hits |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SUPFAMi | SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
i Sequence
Sequence statusi: Complete.
Q58FF7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEEVHHGEE EVETFAFQAE IAQLISLIIN TFYSNEEIFL QELISNASDA
60 70 80 90 100
LDKIRYESLT DPSKLDSGKE LKIDIIPNPQ ERTLALVDTG IGMTKADLIN
110 120 130 140 150
NLRTIAKSGT KACMEALQAE KLVVITKHND DEQYAWESSA GGSFTVHADH
160 170 180 190 200
GEPIGRGTKV ILHLKEDQTE YLEERRVKEV VKKHSQFIGY PITLYLEKEQ
210 220 230 240 250
DKEISDDEAE EEKGEKEEED KDDEEKPKIK DVGSDEEDDS KEYGEFYKSL
260 270 280 290 300
TSDWEDHLAV KHFSVEGQLE FRALLFSPRR APFDLFENKK KKNNIKLYVR
310 320 330 340 350
RVFIMDSCDE LIPEYLNFIH GVVDSEDLPL NISREMLQQS KILKYVSHMK
360 370 380 390 400
ETQKSTYYIT GESKEQVANS AFVERVRKQG FEVVYMTEPI DEYCVQQLKE
410 420 430 440 450
FDGKSLVSVT KEGLELPEDE EEKKKMEESK EKFENLCKLM KEILDKKVEK
460 470 480 490 500
VTISNRLVSS PCCIVTSTYG WTANMEQIMK AQALRDNSTM GYMMAKKHLE
510 520 530 540 550
INPDHPIMET LRQKAEADKN DKAVKDLVVL LFETALLSSG FSLEDPQTHS
560 570 580 590
NHIYHMIKLG LGTDEDEVAA EEPSDAVPDE IPPLEGDEDA SRMEEVD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY956764 mRNA Translation: AAX38251.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY956764 mRNA Translation: AAX38251.1 |
3D structure databases
SMRi | Q58FF7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q58FF7, 58 interactors |
MINTi | Q58FF7 |
PTM databases
GlyConnecti | 1697, 2 N-Linked glycans (2 sites) |
GlyGeni | Q58FF7, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q58FF7 |
PhosphoSitePlusi | Q58FF7 |
SwissPalmi | Q58FF7 |
Polymorphism and mutation databases
BioMutai | HGNC:5259 |
DMDMi | 74722492 |
Proteomic databases
EPDi | Q58FF7 |
jPOSTi | Q58FF7 |
MassIVEi | Q58FF7 |
MaxQBi | Q58FF7 |
PeptideAtlasi | Q58FF7 |
PRIDEi | Q58FF7 |
ProteomicsDBi | 62622 |
TopDownProteomicsi | Q58FF7 |
Organism-specific databases
GeneCardsi | HSP90AB3P |
HGNCi | HGNC:5259, HSP90AB3P |
neXtProti | NX_Q58FF7 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | Q58FF7 |
PhylomeDBi | Q58FF7 |
Enzyme and pathway databases
PathwayCommonsi | Q58FF7 |
Miscellaneous databases
ChiTaRSi | HSP90AB3P, human |
Pharosi | Q58FF7, Tdark |
PROi | PR:Q58FF7 |
RNActi | Q58FF7, protein |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 2 hits |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 3 hits |
Pfami | View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 2 hits |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SUPFAMi | SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H90B3_HUMAN | |
Accessioni | Q58FF7Primary (citable) accession number: Q58FF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | April 26, 2005 | |
Last modified: | October 7, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families