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Entry version 130 (10 Apr 2019)
Sequence version 4 (14 Apr 2009)
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Protein

Bromodomain testis-specific protein

Gene

BRDT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time (PubMed:22901802). In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.By similarity4 Publications

Miscellaneous

BRDT is a promising target for male contraception. Inhibition by thienodiazepine inhibitor (+)-JQ1 that binds Asn-109, prevents recognition of acetylated histone H4, causing a complete and reversible contraceptive effect in male mice (PubMed:22901802).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei109Histone H4K5acBy similarity1
Binding sitei109JQ1 inhibitor1 Publication1
Binding sitei114Histone H4K5acBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processDifferentiation, Meiosis, mRNA processing, mRNA splicing, Spermatogenesis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain testis-specific protein
Alternative name(s):
Cancer/testis antigen 9
Short name:
CT9
RING3-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRDT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137948.18

Human Gene Nomenclature Database

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HGNCi
HGNC:1105 BRDT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602144 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q58F21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure 21 (SPGF21)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infertility disorder caused by spermatogenesis defects and characterized by acephalic spermatozoa in the semen of affected individuals. SPGF21 inheritance is autosomal recessive.
See also OMIM:617644
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079306928G → D in SPGF21; no effect on protein expression; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754258809EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
676

MalaCards human disease database

More...
MalaCardsi
BRDT
MIMi617644 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000137948

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25418

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1795185

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2729

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BRDT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226694198

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002392251 – 947Bromodomain testis-specific proteinAdd BLAST947

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei187PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q58F21

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q58F21

MaxQB - The MaxQuant DataBase

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MaxQBi
Q58F21

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q58F21

PeptideAtlas

More...
PeptideAtlasi
Q58F21

PRoteomics IDEntifications database

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PRIDEi
Q58F21

ProteomicsDB human proteome resource

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ProteomicsDBi
62618
62619 [Q58F21-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q58F21

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q58F21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryo testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000137948 Expressed in 59 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q58F21 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q58F21 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB012237

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with mRNA splicing machinery proteins SRSF2, DDX5, HNRNPK and TARDBP. Interacts with the acetylated N-terminus of histone H1, H2, H3 and H4. Interacts with P-TEFb components CDK9 and CCNT1/cyclin-T1. Interacts with SMARCE1 (By similarity). Interacts with the acetylated N-terminus of histone H1.4, H2A, H2B, H3 and H4.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107143, 5 interactors

Protein interaction database and analysis system

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IntActi
Q58F21, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000387822

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q58F21

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1947
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RFJX-ray2.05A/B/C21-137[»]
4FLPX-ray2.23A/B21-137[»]
4KCXX-ray2.00A/B21-137[»]
5VBQX-ray1.65A/B29-137[»]
5VBRX-ray1.90A/B29-137[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q58F21

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q58F21

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q58F21

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 116Bromo 1PROSITE-ProRule annotationAdd BLAST73
Domaini287 – 359Bromo 2PROSITE-ProRule annotationAdd BLAST73
Domaini500 – 582NETPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili417 – 470Sequence analysisAdd BLAST54
Coiled coili591 – 621Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi209 – 220Nuclear localization signal1 PublicationAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi635 – 667Ser-richAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions (PubMed:22464331). Bromo domain 1 mediates binding with histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) (PubMed:22901802). The bromo domains also recognize and bind a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity).By similarity2 Publications

Keywords - Domaini

Bromodomain, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1474 Eukaryota
COG5076 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154549

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231200

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004896

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q58F21

KEGG Orthology (KO)

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KOi
K11724

Identification of Orthologs from Complete Genome Data

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OMAi
KEPKVSQ

Database of Orthologous Groups

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OrthoDBi
575052at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q58F21

TreeFam database of animal gene trees

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TreeFami
TF317345

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1270.220, 1 hit
1.20.920.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031354 BRD4_CDT
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR027353 NET_dom
IPR038336 NET_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17035 BET, 1 hit
PF17105 BRD4_CDT, 1 hit
PF00439 Bromodomain, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00297 BROMO, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47370 SSF47370, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits
PS51525 NET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q58F21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLPSRQTAI IVNPPPPEYI NTKKNGRLTN QLQYLQKVVL KDLWKHSFSW
60 70 80 90 100
PFQRPVDAVK LQLPDYYTII KNPMDLNTIK KRLENKYYAK ASECIEDFNT
110 120 130 140 150
MFSNCYLYNK PGDDIVLMAQ ALEKLFMQKL SQMPQEEQVV GVKERIKKGT
160 170 180 190 200
QQNIAVSSAK EKSSPSATEK VFKQQEIPSV FPKTSISPLN VVQGASVNSS
210 220 230 240 250
SQTAAQVTKG VKRKADTTTP ATSAVKASSE FSPTFTEKSV ALPPIKENMP
260 270 280 290 300
KNVLPDSQQQ YNVVKTVKVT EQLRHCSEIL KEMLAKKHFS YAWPFYNPVD
310 320 330 340 350
VNALGLHNYY DVVKNPMDLG TIKEKMDNQE YKDAYKFAAD VRLMFMNCYK
360 370 380 390 400
YNPPDHEVVT MARMLQDVFE THFSKIPIEP VESMPLCYIK TDITETTGRE
410 420 430 440 450
NTNEASSEGN SSDDSEDERV KRLAKLQEQL KAVHQQLQVL SQVPFRKLNK
460 470 480 490 500
KKEKSKKEKK KEKVNNSNEN PRKMCEQMRL KEKSKRNQPK KRKQQFIGLK
510 520 530 540 550
SEDEDNAKPM NYDEKRQLSL NINKLPGDKL GRVVHIIQSR EPSLSNSNPD
560 570 580 590 600
EIEIDFETLK ASTLRELEKY VSACLRKRPL KPPAKKIMMS KEELHSQKKQ
610 620 630 640 650
ELEKRLLDVN NQLNSRKRQT KSDKTQPSKA VENVSRLSES SSSSSSSSES
660 670 680 690 700
ESSSSDLSSS DSSDSESEMF PKFTEVKPND SPSKENVKKM KNECIPPEGR
710 720 730 740 750
TGVTQIGYCV QDTTSANTTL VHQTTPSHVM PPNHHQLAFN YQELEHLQTV
760 770 780 790 800
KNISPLQILP PSGDSEQLSN GITVMHPSGD SDTTMLESEC QAPVQKDIKI
810 820 830 840 850
KNADSWKSLG KPVKPSGVMK SSDELFNQFR KAAIEKEVKA RTQELIRKHL
860 870 880 890 900
EQNTKELKAS QENQRDLGNG LTVESFSNKI QNKCSGEEQK EHQQSSEAQD
910 920 930 940
KSKLWLLKDR DLARQKEQER RRREAMVGTI DMTLQSDIMT MFENNFD
Length:947
Mass (Da):107,954
Last modified:April 14, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09C0FD8690E217BB
GO
Isoform 2 (identifier: Q58F21-2) [UniParc]FASTAAdd to basket
Also known as: BRDT-NY

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTCTCRQDSKQLRM

Show »
Length:960
Mass (Da):109,506
Checksum:iD477F897F6D72935
GO
Isoform 3 (identifier: Q58F21-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-148: K → KGKAG

Show »
Length:951
Mass (Da):108,268
Checksum:i8A9508DF12C6AB36
GO
Isoform 4 (identifier: Q58F21-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-110: Missing.

Show »
Length:901
Mass (Da):102,361
Checksum:i64B19CBC80791B60
GO
Isoform 5 (identifier: Q58F21-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.
Show »
Length:874
Mass (Da):99,394
Checksum:iC8A7FAC55BA14F94
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JJU3C9JJU3_HUMAN
Bromodomain testis-specific protein
BRDT
462Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDL5C9JDL5_HUMAN
Bromodomain testis-specific protein
BRDT
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JD82C9JD82_HUMAN
Bromodomain testis-specific protein
BRDT
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0H2F8W0H2_HUMAN
Bromodomain testis-specific protein
BRDT
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLZ2C9JLZ2_HUMAN
Bromodomain testis-specific protein
BRDT
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1F7C9J1F7_HUMAN
Bromodomain testis-specific protein
BRDT
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZ63F8VZ63_HUMAN
Bromodomain testis-specific protein
BRDT
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMP1C9JMP1_HUMAN
Bromodomain testis-specific protein
BRDT
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ27C9JQ27_HUMAN
Bromodomain testis-specific protein
BRDT
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0Z0C9J0Z0_HUMAN
Bromodomain testis-specific protein
BRDT
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH05281 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH47900 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH62700 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42D → N in BAH13876 (PubMed:14702039).Curated1
Sequence conflicti73P → S in AAH05281 (PubMed:15489334).Curated1
Sequence conflicti80K → I in AAH62700 (PubMed:15489334).Curated1
Sequence conflicti265K → E in AAB87862 (PubMed:9367677).Curated1
Sequence conflicti336K → S in AAB87862 (PubMed:9367677).Curated1
Sequence conflicti462E → K in AAH17582 (PubMed:15489334).Curated1
Sequence conflicti477Q → R in BAH13876 (PubMed:14702039).Curated1
Sequence conflicti552I → M in AAQ16198 (PubMed:15647849).Curated1
Sequence conflicti686N → H in AAB87862 (PubMed:9367677).Curated1
Sequence conflicti893Q → P in AAB87862 (PubMed:9367677).Curated1
Sequence conflicti915Q → P in AAB87862 (PubMed:9367677).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0419242S → F1 PublicationCorresponds to variant dbSNP:rs55806733Ensembl.1
Natural variantiVAR_0419256R → Q1 PublicationCorresponds to variant dbSNP:rs56273490Ensembl.1
Natural variantiVAR_02658462Q → K5 PublicationsCorresponds to variant dbSNP:rs10783071Ensembl.1
Natural variantiVAR_04192689A → V in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs781375003Ensembl.1
Natural variantiVAR_026585238K → N2 PublicationsCorresponds to variant dbSNP:rs1156281Ensembl.1
Natural variantiVAR_041927288H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_047327336K → T. Corresponds to variant dbSNP:rs1064567Ensembl.1
Natural variantiVAR_041928357E → K1 PublicationCorresponds to variant dbSNP:rs34674879Ensembl.1
Natural variantiVAR_026586410N → K2 PublicationsCorresponds to variant dbSNP:rs3088232Ensembl.1
Natural variantiVAR_041929542P → A1 PublicationCorresponds to variant dbSNP:rs55912588Ensembl.1
Natural variantiVAR_047328605R → Q. Corresponds to variant dbSNP:rs35327986Ensembl.1
Natural variantiVAR_047329696P → L4 PublicationsCorresponds to variant dbSNP:rs10747493Ensembl.1
Natural variantiVAR_079306928G → D in SPGF21; no effect on protein expression; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754258809EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0445091 – 73Missing in isoform 5. CuratedAdd BLAST73
Alternative sequenceiVSP_0191181M → MTCTCRQDSKQLRM in isoform 2. 1 Publication1
Alternative sequenceiVSP_04451065 – 110Missing in isoform 4. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_044511148K → KGKAG in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF019085 mRNA Translation: AAB87862.1
AY338951 mRNA Translation: AAQ16198.1
AK303008 mRNA Translation: BAH13876.1
AK302758 mRNA Translation: BAH13797.1
AK316442 mRNA Translation: BAH14813.1
AC114486 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73106.1
CH471097 Genomic DNA Translation: EAW73107.1
CH471097 Genomic DNA Translation: EAW73108.1
CH471097 Genomic DNA Translation: EAW73110.1
CH471097 Genomic DNA Translation: EAW73111.1
BC005281 mRNA Translation: AAH05281.1 Sequence problems.
BC017582 mRNA Translation: AAH17582.1
BC047900 mRNA Translation: AAH47900.1 Sequence problems.
BC062700 mRNA Translation: AAH62700.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55615.1 [Q58F21-4]
CCDS55616.1 [Q58F21-5]
CCDS72820.1 [Q58F21-3]
CCDS735.1 [Q58F21-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001229734.2, NM_001242805.2 [Q58F21-1]
NP_001229735.2, NM_001242806.2 [Q58F21-3]
NP_001229736.2, NM_001242807.2 [Q58F21-4]
NP_001229737.2, NM_001242808.2 [Q58F21-4]
NP_001229739.2, NM_001242810.2 [Q58F21-5]
NP_001717.3, NM_001726.4 [Q58F21-1]
NP_997072.2, NM_207189.3 [Q58F21-1]
XP_006710916.1, XM_006710853.3 [Q58F21-1]
XP_006710917.1, XM_006710854.3 [Q58F21-1]
XP_006710918.1, XM_006710855.3 [Q58F21-1]
XP_006710919.1, XM_006710856.3 [Q58F21-1]
XP_006710920.1, XM_006710857.3 [Q58F21-1]
XP_011540334.1, XM_011542032.2 [Q58F21-1]
XP_011540335.1, XM_011542033.2 [Q58F21-1]
XP_011540336.1, XM_011542034.2 [Q58F21-1]
XP_011540337.1, XM_011542035.2 [Q58F21-1]
XP_011540338.1, XM_011542036.2 [Q58F21-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.482520

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000362005; ENSP00000354568; ENSG00000137948 [Q58F21-1]
ENST00000370389; ENSP00000359416; ENSG00000137948 [Q58F21-5]
ENST00000394530; ENSP00000378038; ENSG00000137948 [Q58F21-4]
ENST00000399546; ENSP00000387822; ENSG00000137948 [Q58F21-3]
ENST00000402388; ENSP00000384051; ENSG00000137948 [Q58F21-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
676

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:676

UCSC genome browser

More...
UCSCi
uc001dol.5 human [Q58F21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Asking life to be patient - Issue 144 of November 2012

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019085 mRNA Translation: AAB87862.1
AY338951 mRNA Translation: AAQ16198.1
AK303008 mRNA Translation: BAH13876.1
AK302758 mRNA Translation: BAH13797.1
AK316442 mRNA Translation: BAH14813.1
AC114486 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73106.1
CH471097 Genomic DNA Translation: EAW73107.1
CH471097 Genomic DNA Translation: EAW73108.1
CH471097 Genomic DNA Translation: EAW73110.1
CH471097 Genomic DNA Translation: EAW73111.1
BC005281 mRNA Translation: AAH05281.1 Sequence problems.
BC017582 mRNA Translation: AAH17582.1
BC047900 mRNA Translation: AAH47900.1 Sequence problems.
BC062700 mRNA Translation: AAH62700.1 Sequence problems.
CCDSiCCDS55615.1 [Q58F21-4]
CCDS55616.1 [Q58F21-5]
CCDS72820.1 [Q58F21-3]
CCDS735.1 [Q58F21-1]
RefSeqiNP_001229734.2, NM_001242805.2 [Q58F21-1]
NP_001229735.2, NM_001242806.2 [Q58F21-3]
NP_001229736.2, NM_001242807.2 [Q58F21-4]
NP_001229737.2, NM_001242808.2 [Q58F21-4]
NP_001229739.2, NM_001242810.2 [Q58F21-5]
NP_001717.3, NM_001726.4 [Q58F21-1]
NP_997072.2, NM_207189.3 [Q58F21-1]
XP_006710916.1, XM_006710853.3 [Q58F21-1]
XP_006710917.1, XM_006710854.3 [Q58F21-1]
XP_006710918.1, XM_006710855.3 [Q58F21-1]
XP_006710919.1, XM_006710856.3 [Q58F21-1]
XP_006710920.1, XM_006710857.3 [Q58F21-1]
XP_011540334.1, XM_011542032.2 [Q58F21-1]
XP_011540335.1, XM_011542033.2 [Q58F21-1]
XP_011540336.1, XM_011542034.2 [Q58F21-1]
XP_011540337.1, XM_011542035.2 [Q58F21-1]
XP_011540338.1, XM_011542036.2 [Q58F21-1]
UniGeneiHs.482520

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RFJX-ray2.05A/B/C21-137[»]
4FLPX-ray2.23A/B21-137[»]
4KCXX-ray2.00A/B21-137[»]
5VBQX-ray1.65A/B29-137[»]
5VBRX-ray1.90A/B29-137[»]
ProteinModelPortaliQ58F21
SMRiQ58F21
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107143, 5 interactors
IntActiQ58F21, 2 interactors
STRINGi9606.ENSP00000387822

Chemistry databases

BindingDBiQ58F21
ChEMBLiCHEMBL1795185
GuidetoPHARMACOLOGYi2729

PTM databases

iPTMnetiQ58F21
PhosphoSitePlusiQ58F21

Polymorphism and mutation databases

BioMutaiBRDT
DMDMi226694198

Proteomic databases

EPDiQ58F21
jPOSTiQ58F21
MaxQBiQ58F21
PaxDbiQ58F21
PeptideAtlasiQ58F21
PRIDEiQ58F21
ProteomicsDBi62618
62619 [Q58F21-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
676
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362005; ENSP00000354568; ENSG00000137948 [Q58F21-1]
ENST00000370389; ENSP00000359416; ENSG00000137948 [Q58F21-5]
ENST00000394530; ENSP00000378038; ENSG00000137948 [Q58F21-4]
ENST00000399546; ENSP00000387822; ENSG00000137948 [Q58F21-3]
ENST00000402388; ENSP00000384051; ENSG00000137948 [Q58F21-1]
GeneIDi676
KEGGihsa:676
UCSCiuc001dol.5 human [Q58F21-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
676
DisGeNETi676
EuPathDBiHostDB:ENSG00000137948.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BRDT
HGNCiHGNC:1105 BRDT
HPAiCAB012237
MalaCardsiBRDT
MIMi602144 gene
617644 phenotype
neXtProtiNX_Q58F21
OpenTargetsiENSG00000137948
PharmGKBiPA25418

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1474 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00940000154549
HOGENOMiHOG000231200
HOVERGENiHBG004896
InParanoidiQ58F21
KOiK11724
OMAiKEPKVSQ
OrthoDBi575052at2759
PhylomeDBiQ58F21
TreeFamiTF317345

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BRDT human
EvolutionaryTraceiQ58F21

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BRDT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
676

Protein Ontology

More...
PROi
PR:Q58F21

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137948 Expressed in 59 organ(s), highest expression level in testis
ExpressionAtlasiQ58F21 baseline and differential
GenevisibleiQ58F21 HS

Family and domain databases

Gene3Di1.20.1270.220, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR031354 BRD4_CDT
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR027353 NET_dom
IPR038336 NET_sf
PfamiView protein in Pfam
PF17035 BET, 1 hit
PF17105 BRD4_CDT, 1 hit
PF00439 Bromodomain, 2 hits
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits
PS51525 NET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRDT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q58F21
Secondary accession number(s): A6NF68
, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q6P5T1, Q7Z4A6, Q8IWI6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: April 14, 2009
Last modified: April 10, 2019
This is version 130 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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