UniProtKB - Q58EX2 (SDK2_HUMAN)
Protein sidekick-2
SDK2
Functioni
GO - Biological processi
- camera-type eye photoreceptor cell differentiation Source: UniProtKB
- cell-cell junction organization Source: Reactome
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- retina layer formation Source: UniProtKB
- synapse assembly Source: UniProtKB
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q58EX2 |
Reactomei | R-HSA-373756, SDK interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Protein sidekick-2By similarity |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000069188.16 |
HGNCi | HGNC:19308, SDK2 |
MIMi | 607217, gene |
neXtProti | NX_Q58EX2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- synapse By similarity
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- synapse Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 1932 | ExtracellularSequence analysisAdd BLAST | 1912 | |
Transmembranei | 1933 – 1953 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1954 – 2172 | CytoplasmicSequence analysisAdd BLAST | 219 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 54549 |
OpenTargetsi | ENSG00000069188 |
PharmGKBi | PA134981456 |
Miscellaneous databases
Pharosi | Q58EX2, Tdark |
Polymorphism and mutation databases
BioMutai | SDK2 |
DMDMi | 296452966 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000226978 | 21 – 2172 | Protein sidekick-2Add BLAST | 2152 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 48 ↔ 91 | PROSITE-ProRule annotation | ||
Glycosylationi | 193 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 237 ↔ 284 | PROSITE-ProRule annotation | ||
Disulfide bondi | 330 ↔ 380 | PROSITE-ProRule annotation | ||
Disulfide bondi | 423 ↔ 475 | PROSITE-ProRule annotation | ||
Disulfide bondi | 517 ↔ 569 | PROSITE-ProRule annotation | ||
Glycosylationi | 609 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 743 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 936 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 948 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1670 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q58EX2 |
jPOSTi | Q58EX2 |
MassIVEi | Q58EX2 |
MaxQBi | Q58EX2 |
PaxDbi | Q58EX2 |
PeptideAtlasi | Q58EX2 |
PRIDEi | Q58EX2 |
ProteomicsDBi | 62611 [Q58EX2-1] 62612 [Q58EX2-2] 62613 [Q58EX2-3] 62614 [Q58EX2-4] |
PTM databases
GlyGeni | Q58EX2, 7 sites |
iPTMneti | Q58EX2 |
PhosphoSitePlusi | Q58EX2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000069188, Expressed in cartilage tissue and 201 other tissues |
ExpressionAtlasi | Q58EX2, baseline and differential |
Genevisiblei | Q58EX2, HS |
Organism-specific databases
HPAi | ENSG00000069188, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Homodimer; mediates homophilic interactions to promote cell adhesion.
Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4.
By similarityBinary interactionsi
Q58EX2
With | #Exp. | IntAct |
---|---|---|
VMAC [Q2NL98] | 3 | EBI-2801316,EBI-2803134 |
Protein-protein interaction databases
BioGRIDi | 120034, 21 interactors |
IntActi | Q58EX2, 18 interactors |
STRINGi | 9606.ENSP00000376421 |
Miscellaneous databases
RNActi | Q58EX2, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q58EX2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q58EX2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 108 | Ig-like C2-type 1Add BLAST | 83 | |
Domaini | 113 – 200 | Ig-like C2-type 2Add BLAST | 88 | |
Domaini | 215 – 294 | Ig-like C2-type 3Add BLAST | 80 | |
Domaini | 308 – 396 | Ig-like C2-type 4Add BLAST | 89 | |
Domaini | 402 – 491 | Ig-like C2-type 5Add BLAST | 90 | |
Domaini | 496 – 585 | Ig-like C2-type 6Add BLAST | 90 | |
Domaini | 592 – 688 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 693 – 789 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 794 – 893 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 897 – 991 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 995 – 1094 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 1099 – 1197 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 1202 – 1299 | Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 1303 – 1397 | Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 1402 – 1499 | Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 1504 – 1621 | Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 1626 – 1722 | Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 1726 – 1821 | Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 1824 – 1923 | Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST | 100 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 2166 – 2172 | PDZ-bindingBy similarity | 7 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3510, Eukaryota KOG4221, Eukaryota |
GeneTreei | ENSGT00940000155761 |
HOGENOMi | CLU_001875_1_0_1 |
InParanoidi | Q58EX2 |
OMAi | DKYTEYR |
OrthoDBi | 134749at2759 |
PhylomeDBi | Q58EX2 |
TreeFami | TF316846 |
Family and domain databases
CDDi | cd00063, FN3, 13 hits |
Gene3Di | 2.60.40.10, 19 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 13 hits PF07679, I-set, 3 hits |
SMARTi | View protein in SMART SM00060, FN3, 13 hits SM00409, IG, 6 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 7 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 13 hits PS50835, IG_LIKE, 6 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWGLLIWTLL ALHQIRAARA QDDVSPYFKT EPVRTQVHLE GNRLVLTCMA
60 70 80 90 100
EGSWPLEFKW LHNNRELTKF SLEYRYMITS LDRTHAGFYR CIVRNRMGAL
110 120 130 140 150
LQRQTEVQVA YMGSFEEGEK HQSVSHGEAA VIRAPRIASF PQPQVTWFRD
160 170 180 190 200
GRKIPPSSRI AITLENTLVI LSTVAPDAGR YYVQAVNDKN GDNKTSQPIT
210 220 230 240 250
LTVENVGGPA DPIAPTIIIP PKNTSVVAGT SEVTLECVAN ARPLIKLHII
260 270 280 290 300
WKKDGVLLSG GISDHNRRLT IPNPTGSDAG YYECEAVLRS SSVPSVVRGA
310 320 330 340 350
YLSVLEPPQF VKEPERHITA EMEKVVDIPC QAKGVPPPSI TWYKDAAVVE
360 370 380 390 400
VEKLTRFRQR NDGGLQISGL VPDDTGMFQC FARNAAGEVQ TSTYLAVTSI
410 420 430 440 450
APNITRGPLD STVIDGMSVV LACETSGAPR PAITWQKGER ILASGSVQLP
460 470 480 490 500
RFTPLESGSL LISPTHISDA GTYTCLATNS RGVDEASADL VVWARTRITK
510 520 530 540 550
PPQDQSVIKG TQASMVCGVT HDPRVTIRYI WEKDGATLGT ESHPRIRLDR
560 570 580 590 600
NGSLHISQTW SGDIGTYTCR VISAGGNDSR SAHLRVRQLP HAPEHPVATL
610 620 630 640 650
STVERRAINL TWTKPFDGNS PLIRYILEMS ENNAPWTVLL ASVDPKATSV
660 670 680 690 700
TVKGLVPARS YQFRLCAVND VGKGQFSKDT ERVSLPEEPP TAPPQNVIAS
710 720 730 740 750
GRTNQSIMIQ WQPPPESHQN GILKGYIIRY CLAGLPVGYQ FKNITDADVN
760 770 780 790 800
NLLLEDLIIW TNYEIEVAAY NSAGLGVYSS KVTEWTLQGV PTVPPGNVHA
810 820 830 840 850
EATNSTTIRF TWNAPSPQFI NGINQGYKLI AWEPEQEEEV TMVTARPNFQ
860 870 880 890 900
DSIHVGFVSG LKKFTEYFTS VLCFTTPGDG PRSTPQLVRT HEDVPGPVGH
910 920 930 940 950
LSFSEILDTS LKVSWQEPGE KNGILTGYRI SWEEYNRTNT RVTHYLPNVT
960 970 980 990 1000
LEYRVTGLTA LTTYTIEVAA MTSKGQGQVS ASTISSGVPP ELPGPPTNLG
1010 1020 1030 1040 1050
ISNIGPRSVT LQFRPGYDGK TSISRWLVEA QVGVVGEGEE WLLIHQLSNE
1060 1070 1080 1090 1100
PDARSMEVPD LNPFTCYSFR MRQVNIVGTS PPSQPSRKIQ TLQAPPDMAP
1110 1120 1130 1140 1150
ANVSLRTASE TSLWLRWMPL PEMEYNGNPE SVGYKIKYSR SDGHGKTLSH
1160 1170 1180 1190 1200
VVQDRVERDY TIEDLEEWTE YRVQVQAFNA IGSGPWSQTV VGRTRESVPS
1210 1220 1230 1240 1250
SGPTNVSALA TTSSSMLVRW SEVPEADRNG LVLGYKVMYK EKDSDTQPRF
1260 1270 1280 1290 1300
WLVEGNSSRS AQLTGLGKYV LYEVQVLAFT RIGDGSPSHP PILERTLDDV
1310 1320 1330 1340 1350
PGPPMGILFP EVRTTSVRLI WQPPAAPNGI ILAYQITHRL NTTTANTATV
1360 1370 1380 1390 1400
EVLAPSARQY TATGLKPESV YLFRITAQTR KGWGEAAEAL VVTTEKRDRP
1410 1420 1430 1440 1450
QPPSRPMVQQ EDVRARSVLL SWEPGSDGLS PVRYYTIQTR ELPSGRWALH
1460 1470 1480 1490 1500
SASVSHNASS FIVDRLKPFT SYKFRVKATN DIGDSEFSEE SESLTTLQAA
1510 1520 1530 1540 1550
PDEAPTILSV TPHTTTSVLI RWQPPAEDKI NGILLGFRIR YRELLYEGLR
1560 1570 1580 1590 1600
GFTLRGINNP GATWAELTSM YSMRNLSRPS LTQYELDNLN KHRRYEIRMS
1610 1620 1630 1640 1650
VYNAVGEGPS SPPQEVFVGE AVPTAAPRNV VVHGATATQL DVTWEPPPLD
1660 1670 1680 1690 1700
SQNGDIQGYK IYFWEAQRGN LTERVKTLFL AENSVKLKNL TGYTAYMVSV
1710 1720 1730 1740 1750
AAFNAAGDGP RSTPTQGQTQ QAAPSAPSSV KFSELTTTSV NVSWEAPQFP
1760 1770 1780 1790 1800
NGILEGYRLV YEPCSPVDGV SKIVTVDVKG NSPLWLKVKD LAEGVTYRFR
1810 1820 1830 1840 1850
IRAKTFTYGP EIEANVTTGP GEGAPGPPGV PIIVRYSSAI AIHWSSGDPG
1860 1870 1880 1890 1900
KGPITRYVIE ARPSDEGLWD ILIKDIPKEV SSYTFSMDIL KPGVSYDFRV
1910 1920 1930 1940 1950
IAVNDYGFGT PSSPSQSVPA QKANPFYEEW WFLVVIALVG LIFILLLVFV
1960 1970 1980 1990 2000
LIIRGQSKKY AKKTDSGNSA KSGALGHSEM MSLDESSFPA LELNNRRLSV
2010 2020 2030 2040 2050
KNSFCRKNGL YTRSPPRPSP GSLHYSDEDV TKYNDLIPAE SSSLTEKPSE
2060 2070 2080 2090 2100
ISDSQGSDSE YEVDSNHQKA HSFVNHYISD PTYYNSWRRQ QKGISRAQAY
2110 2120 2130 2140 2150
SYTESDSGEP DHTTVTNSTS TQQGSLFRPK ASRTPTPQNP PNPPSQQSTL
2160 2170
YRPPSSLAPG SRAPIAGFSS FV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C2P2 | H7C2P2_HUMAN | Protein sidekick-2 | SDK2 | 1,329 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1218 | V → G in CAB70709 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1382 | G → V in CAB70709 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1553 | T → M in AAH45763 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1553 | T → M in AAH66363 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1680 | L → P in BAA91841 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2092 | K → R in BAA91841 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080771 | 376 | G → S Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs372925045Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017522 | 1569 – 1588 | SMYSM…YELDN → Y in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_017523 | 1865 – 1921 | DEGLW…SVPAQ → GAPRPAGLRPHSSLSPFFLG PSTWGTCLCPPPEKALVLLQ VKSPGPVEEWETGLGGS in isoform 2. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_017524 | 1922 – 2172 | Missing in isoform 2. 1 PublicationAdd BLAST | 251 | |
Alternative sequenceiVSP_017525 | 2156 – 2172 | SLAPG…FSSFV → KAGVQKEGENRERMCVASSS SALRWWGSLLPWELHGAGEV AVSLLWTRSGPGIWRERGSG G in isoform 4. 1 PublicationAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC032019 Genomic DNA No translation available. AC087301 Genomic DNA No translation available. AC124804 Genomic DNA No translation available. AB040947 mRNA Translation: BAA96038.1 BC045763 mRNA Translation: AAH45763.1 BC066363 mRNA Translation: AAH66363.1 AL137357 mRNA Translation: CAB70709.1 AK001694 mRNA Translation: BAA91841.1 Different initiation. |
CCDSi | CCDS45769.1 [Q58EX2-1] |
PIRi | T46428 |
RefSeqi | NP_001138424.1, NM_001144952.1 [Q58EX2-1] XP_011523216.1, XM_011524914.2 [Q58EX2-3] |
Genome annotation databases
Ensembli | ENST00000392650; ENSP00000376421; ENSG00000069188 [Q58EX2-1] |
GeneIDi | 54549 |
KEGGi | hsa:54549 |
UCSCi | uc010dfm.4, human [Q58EX2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Discerning change - Issue 176 of February 2016 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC032019 Genomic DNA No translation available. AC087301 Genomic DNA No translation available. AC124804 Genomic DNA No translation available. AB040947 mRNA Translation: BAA96038.1 BC045763 mRNA Translation: AAH45763.1 BC066363 mRNA Translation: AAH66363.1 AL137357 mRNA Translation: CAB70709.1 AK001694 mRNA Translation: BAA91841.1 Different initiation. |
CCDSi | CCDS45769.1 [Q58EX2-1] |
PIRi | T46428 |
RefSeqi | NP_001138424.1, NM_001144952.1 [Q58EX2-1] XP_011523216.1, XM_011524914.2 [Q58EX2-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WF5 | NMR | - | A | 580-687 | [»] | |
1WFN | NMR | - | A | 885-990 | [»] | |
1WFO | NMR | - | A | 1281-1397 | [»] | |
1WIS | NMR | - | A | 983-1093 | [»] | |
SMRi | Q58EX2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120034, 21 interactors |
IntActi | Q58EX2, 18 interactors |
STRINGi | 9606.ENSP00000376421 |
PTM databases
GlyGeni | Q58EX2, 7 sites |
iPTMneti | Q58EX2 |
PhosphoSitePlusi | Q58EX2 |
Polymorphism and mutation databases
BioMutai | SDK2 |
DMDMi | 296452966 |
Proteomic databases
EPDi | Q58EX2 |
jPOSTi | Q58EX2 |
MassIVEi | Q58EX2 |
MaxQBi | Q58EX2 |
PaxDbi | Q58EX2 |
PeptideAtlasi | Q58EX2 |
PRIDEi | Q58EX2 |
ProteomicsDBi | 62611 [Q58EX2-1] 62612 [Q58EX2-2] 62613 [Q58EX2-3] 62614 [Q58EX2-4] |
Protocols and materials databases
Antibodypediai | 2228, 17 antibodies |
DNASUi | 54549 |
Genome annotation databases
Ensembli | ENST00000392650; ENSP00000376421; ENSG00000069188 [Q58EX2-1] |
GeneIDi | 54549 |
KEGGi | hsa:54549 |
UCSCi | uc010dfm.4, human [Q58EX2-1] |
Organism-specific databases
CTDi | 54549 |
DisGeNETi | 54549 |
EuPathDBi | HostDB:ENSG00000069188.16 |
GeneCardsi | SDK2 |
HGNCi | HGNC:19308, SDK2 |
HPAi | ENSG00000069188, Tissue enhanced (testis) |
MIMi | 607217, gene |
neXtProti | NX_Q58EX2 |
OpenTargetsi | ENSG00000069188 |
PharmGKBi | PA134981456 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3510, Eukaryota KOG4221, Eukaryota |
GeneTreei | ENSGT00940000155761 |
HOGENOMi | CLU_001875_1_0_1 |
InParanoidi | Q58EX2 |
OMAi | DKYTEYR |
OrthoDBi | 134749at2759 |
PhylomeDBi | Q58EX2 |
TreeFami | TF316846 |
Enzyme and pathway databases
PathwayCommonsi | Q58EX2 |
Reactomei | R-HSA-373756, SDK interactions |
Miscellaneous databases
BioGRID-ORCSi | 54549, 5 hits in 839 CRISPR screens |
ChiTaRSi | SDK2, human |
EvolutionaryTracei | Q58EX2 |
GeneWikii | SDK2 |
GenomeRNAii | 54549 |
Pharosi | Q58EX2, Tdark |
PROi | PR:Q58EX2 |
RNActi | Q58EX2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000069188, Expressed in cartilage tissue and 201 other tissues |
ExpressionAtlasi | Q58EX2, baseline and differential |
Genevisiblei | Q58EX2, HS |
Family and domain databases
CDDi | cd00063, FN3, 13 hits |
Gene3Di | 2.60.40.10, 19 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 13 hits PF07679, I-set, 3 hits |
SMARTi | View protein in SMART SM00060, FN3, 13 hits SM00409, IG, 6 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 7 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 13 hits PS50835, IG_LIKE, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SDK2_HUMAN | |
Accessioni | Q58EX2Primary (citable) accession number: Q58EX2 Secondary accession number(s): A6NMR8 Q9P214 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations