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UniProtKB - Q58EX2 (SDK2_HUMAN)

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Protein

Protein sidekick-2

Gene

SDK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions.By similarity

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-373756 SDK interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sidekick-2By similarity
Gene namesi
Name:SDK2By similarityImported
Synonyms:KIAA15141 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000069188.16
HGNCiHGNC:19308 SDK2
MIMi607217 gene
neXtProtiNX_Q58EX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 1932ExtracellularSequence analysisAdd BLAST1912
Transmembranei1933 – 1953HelicalSequence analysisAdd BLAST21
Topological domaini1954 – 2172CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000069188
PharmGKBiPA134981456

Polymorphism and mutation databases

BioMutaiSDK2
DMDMi296452966

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000022697821 – 2172Protein sidekick-2Add BLAST2152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 91PROSITE-ProRule annotation
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi237 ↔ 284PROSITE-ProRule annotation
Disulfide bondi330 ↔ 380PROSITE-ProRule annotation
Disulfide bondi423 ↔ 475PROSITE-ProRule annotation
Disulfide bondi517 ↔ 569PROSITE-ProRule annotation
Glycosylationi609N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi743N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi936N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi948N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1670N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ58EX2
MaxQBiQ58EX2
PaxDbiQ58EX2
PeptideAtlasiQ58EX2
PRIDEiQ58EX2
ProteomicsDBi62611
62612 [Q58EX2-2]
62613 [Q58EX2-3]
62614 [Q58EX2-4]

PTM databases

iPTMnetiQ58EX2
PhosphoSitePlusiQ58EX2

Expressioni

Gene expression databases

BgeeiENSG00000069188
CleanExiHS_SDK2
ExpressionAtlasiQ58EX2 baseline and differential
GenevisibleiQ58EX2 HS

Organism-specific databases

HPAiHPA014725

Interactioni

Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion. Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4.By similarity

Protein-protein interaction databases

BioGridi120034, 16 interactors
IntActiQ58EX2, 2 interactors
STRINGi9606.ENSP00000376421

Structurei

Secondary structure

12172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi597 – 600Combined sources4
Beta strandi602 – 604Combined sources3
Beta strandi607 – 611Combined sources5
Beta strandi622 – 630Combined sources9
Beta strandi637 – 642Combined sources6
Beta strandi649 – 654Combined sources6
Beta strandi660 – 671Combined sources12
Beta strandi673 – 676Combined sources4
Beta strandi902 – 905Combined sources4
Beta strandi908 – 914Combined sources7
Beta strandi927 – 936Combined sources10
Helixi938 – 940Combined sources3
Beta strandi944 – 946Combined sources3
Beta strandi952 – 957Combined sources6
Beta strandi963 – 971Combined sources9
Beta strandi976 – 985Combined sources10
Beta strandi997 – 1003Combined sources7
Beta strandi1009 – 1014Combined sources6
Beta strandi1024 – 1030Combined sources7
Beta strandi1042 – 1049Combined sources8
Beta strandi1054 – 1058Combined sources5
Beta strandi1065 – 1067Combined sources3
Beta strandi1072 – 1074Combined sources3
Beta strandi1308 – 1312Combined sources5
Beta strandi1314 – 1320Combined sources7
Beta strandi1333 – 1342Combined sources10
Beta strandi1350 – 1353Combined sources4
Beta strandi1359 – 1364Combined sources6
Beta strandi1367 – 1378Combined sources12
Beta strandi1383 – 1392Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF5NMR-A580-687[»]
1WFNNMR-A885-990[»]
1WFONMR-A1281-1397[»]
1WISNMR-A983-1093[»]
ProteinModelPortaliQ58EX2
SMRiQ58EX2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58EX2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 108Ig-like C2-type 1Add BLAST83
Domaini113 – 200Ig-like C2-type 2Add BLAST88
Domaini215 – 294Ig-like C2-type 3Add BLAST80
Domaini308 – 396Ig-like C2-type 4Add BLAST89
Domaini402 – 491Ig-like C2-type 5Add BLAST90
Domaini496 – 585Ig-like C2-type 6Add BLAST90
Domaini592 – 688Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini693 – 789Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini794 – 893Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini897 – 991Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini995 – 1094Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100
Domaini1099 – 1197Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST99
Domaini1202 – 1299Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST98
Domaini1303 – 1397Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1402 – 1499Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98
Domaini1504 – 1621Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST118
Domaini1626 – 1722Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST97
Domaini1726 – 1821Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST96
Domaini1824 – 1923Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST100

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2166 – 2172PDZ-bindingBy similarity7

Domaini

the PDZ-binding motif mediates interaction with PDZ domain-containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors.By similarity

Sequence similaritiesi

Belongs to the sidekick family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQJJ Eukaryota
ENOG410YMNG LUCA
GeneTreeiENSGT00910000144009
HOVERGENiHBG080083
InParanoidiQ58EX2
KOiK16353
OMAiAPTIIIP
OrthoDBiEOG091G0607
PhylomeDBiQ58EX2
TreeFamiTF316846

Family and domain databases

CDDicd00063 FN3, 13 hits
Gene3Di2.60.40.10, 19 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 13 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 13 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 7 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 13 hits
PS50835 IG_LIKE, 6 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q58EX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWGLLIWTLL ALHQIRAARA QDDVSPYFKT EPVRTQVHLE GNRLVLTCMA 
        60         70         80         90        100
EGSWPLEFKW LHNNRELTKF SLEYRYMITS LDRTHAGFYR CIVRNRMGAL 
       110        120        130        140        150
LQRQTEVQVA YMGSFEEGEK HQSVSHGEAA VIRAPRIASF PQPQVTWFRD 
       160        170        180        190        200
GRKIPPSSRI AITLENTLVI LSTVAPDAGR YYVQAVNDKN GDNKTSQPIT 
       210        220        230        240        250
LTVENVGGPA DPIAPTIIIP PKNTSVVAGT SEVTLECVAN ARPLIKLHII 
       260        270        280        290        300
WKKDGVLLSG GISDHNRRLT IPNPTGSDAG YYECEAVLRS SSVPSVVRGA 
       310        320        330        340        350
YLSVLEPPQF VKEPERHITA EMEKVVDIPC QAKGVPPPSI TWYKDAAVVE 
       360        370        380        390        400
VEKLTRFRQR NDGGLQISGL VPDDTGMFQC FARNAAGEVQ TSTYLAVTSI 
       410        420        430        440        450
APNITRGPLD STVIDGMSVV LACETSGAPR PAITWQKGER ILASGSVQLP 
       460        470        480        490        500
RFTPLESGSL LISPTHISDA GTYTCLATNS RGVDEASADL VVWARTRITK 
       510        520        530        540        550
PPQDQSVIKG TQASMVCGVT HDPRVTIRYI WEKDGATLGT ESHPRIRLDR 
       560        570        580        590        600
NGSLHISQTW SGDIGTYTCR VISAGGNDSR SAHLRVRQLP HAPEHPVATL 
       610        620        630        640        650
STVERRAINL TWTKPFDGNS PLIRYILEMS ENNAPWTVLL ASVDPKATSV 
       660        670        680        690        700
TVKGLVPARS YQFRLCAVND VGKGQFSKDT ERVSLPEEPP TAPPQNVIAS 
       710        720        730        740        750
GRTNQSIMIQ WQPPPESHQN GILKGYIIRY CLAGLPVGYQ FKNITDADVN 
       760        770        780        790        800
NLLLEDLIIW TNYEIEVAAY NSAGLGVYSS KVTEWTLQGV PTVPPGNVHA 
       810        820        830        840        850
EATNSTTIRF TWNAPSPQFI NGINQGYKLI AWEPEQEEEV TMVTARPNFQ 
       860        870        880        890        900
DSIHVGFVSG LKKFTEYFTS VLCFTTPGDG PRSTPQLVRT HEDVPGPVGH 
       910        920        930        940        950
LSFSEILDTS LKVSWQEPGE KNGILTGYRI SWEEYNRTNT RVTHYLPNVT 
       960        970        980        990       1000
LEYRVTGLTA LTTYTIEVAA MTSKGQGQVS ASTISSGVPP ELPGPPTNLG 
      1010       1020       1030       1040       1050
ISNIGPRSVT LQFRPGYDGK TSISRWLVEA QVGVVGEGEE WLLIHQLSNE 
      1060       1070       1080       1090       1100
PDARSMEVPD LNPFTCYSFR MRQVNIVGTS PPSQPSRKIQ TLQAPPDMAP 
      1110       1120       1130       1140       1150
ANVSLRTASE TSLWLRWMPL PEMEYNGNPE SVGYKIKYSR SDGHGKTLSH 
      1160       1170       1180       1190       1200
VVQDRVERDY TIEDLEEWTE YRVQVQAFNA IGSGPWSQTV VGRTRESVPS 
      1210       1220       1230       1240       1250
SGPTNVSALA TTSSSMLVRW SEVPEADRNG LVLGYKVMYK EKDSDTQPRF 
      1260       1270       1280       1290       1300
WLVEGNSSRS AQLTGLGKYV LYEVQVLAFT RIGDGSPSHP PILERTLDDV 
      1310       1320       1330       1340       1350
PGPPMGILFP EVRTTSVRLI WQPPAAPNGI ILAYQITHRL NTTTANTATV 
      1360       1370       1380       1390       1400
EVLAPSARQY TATGLKPESV YLFRITAQTR KGWGEAAEAL VVTTEKRDRP 
      1410       1420       1430       1440       1450
QPPSRPMVQQ EDVRARSVLL SWEPGSDGLS PVRYYTIQTR ELPSGRWALH 
      1460       1470       1480       1490       1500
SASVSHNASS FIVDRLKPFT SYKFRVKATN DIGDSEFSEE SESLTTLQAA 
      1510       1520       1530       1540       1550
PDEAPTILSV TPHTTTSVLI RWQPPAEDKI NGILLGFRIR YRELLYEGLR 
      1560       1570       1580       1590       1600
GFTLRGINNP GATWAELTSM YSMRNLSRPS LTQYELDNLN KHRRYEIRMS 
      1610       1620       1630       1640       1650
VYNAVGEGPS SPPQEVFVGE AVPTAAPRNV VVHGATATQL DVTWEPPPLD 
      1660       1670       1680       1690       1700
SQNGDIQGYK IYFWEAQRGN LTERVKTLFL AENSVKLKNL TGYTAYMVSV 
      1710       1720       1730       1740       1750
AAFNAAGDGP RSTPTQGQTQ QAAPSAPSSV KFSELTTTSV NVSWEAPQFP 
      1760       1770       1780       1790       1800
NGILEGYRLV YEPCSPVDGV SKIVTVDVKG NSPLWLKVKD LAEGVTYRFR 
      1810       1820       1830       1840       1850
IRAKTFTYGP EIEANVTTGP GEGAPGPPGV PIIVRYSSAI AIHWSSGDPG 
      1860       1870       1880       1890       1900
KGPITRYVIE ARPSDEGLWD ILIKDIPKEV SSYTFSMDIL KPGVSYDFRV 
      1910       1920       1930       1940       1950
IAVNDYGFGT PSSPSQSVPA QKANPFYEEW WFLVVIALVG LIFILLLVFV 
      1960       1970       1980       1990       2000
LIIRGQSKKY AKKTDSGNSA KSGALGHSEM MSLDESSFPA LELNNRRLSV 
      2010       2020       2030       2040       2050
KNSFCRKNGL YTRSPPRPSP GSLHYSDEDV TKYNDLIPAE SSSLTEKPSE 
      2060       2070       2080       2090       2100
ISDSQGSDSE YEVDSNHQKA HSFVNHYISD PTYYNSWRRQ QKGISRAQAY 
      2110       2120       2130       2140       2150
SYTESDSGEP DHTTVTNSTS TQQGSLFRPK ASRTPTPQNP PNPPSQQSTL 
      2160       2170 
YRPPSSLAPG SRAPIAGFSS FV
Length:2,172
Mass (Da):239,396
Last modified:May 18, 2010 - v3
Checksum:i3CAF9FE659C72A03
GO
Isoform 2 (identifier: Q58EX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1865-1921: DEGLWDILIK...SSPSQSVPAQ → GAPRPAGLRP...EEWETGLGGS
     1922-2172: Missing.

Note: No experimental confirmation available.
Show »
Length:1,921
Mass (Da):211,180
Checksum:i1788A7BE49FA74D4
GO
Isoform 3 (identifier: Q58EX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1588: SMYSMRNLSRPSLTQYELDN → Y

Note: No experimental confirmation available.
Show »
Length:2,153
Mass (Da):237,172
Checksum:iCC6B77234A0DF50A
GO
Isoform 4 (identifier: Q58EX2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2156-2172: SLAPGSRAPIAGFSSFV → KAGVQKEGEN...GIWRERGSGG

Note: No experimental confirmation available.
Show »
Length:2,216
Mass (Da):244,370
Checksum:i0D3DD65A6908A0D5
GO

Sequence cautioni

The sequence BAA91841 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1218V → G in CAB70709 (PubMed:17974005).Curated1
Sequence conflicti1382G → V in CAB70709 (PubMed:17974005).Curated1
Sequence conflicti1553T → M in AAH45763 (PubMed:15489334).Curated1
Sequence conflicti1553T → M in AAH66363 (PubMed:15489334).Curated1
Sequence conflicti1680L → P in BAA91841 (PubMed:14702039).Curated1
Sequence conflicti2092K → R in BAA91841 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0175221569 – 1588SMYSM…YELDN → Y in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0175231865 – 1921DEGLW…SVPAQ → GAPRPAGLRPHSSLSPFFLG PSTWGTCLCPPPEKALVLLQ VKSPGPVEEWETGLGGS in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0175241922 – 2172Missing in isoform 2. 1 PublicationAdd BLAST251
Alternative sequenceiVSP_0175252156 – 2172SLAPG…FSSFV → KAGVQKEGENRERMCVASSS SALRWWGSLLPWELHGAGEV AVSLLWTRSGPGIWRERGSG G in isoform 4. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC032019 Genomic DNA No translation available.
AC087301 Genomic DNA No translation available.
AC124804 Genomic DNA No translation available.
AB040947 mRNA Translation: BAA96038.1
BC045763 mRNA Translation: AAH45763.1
BC066363 mRNA Translation: AAH66363.1
AL137357 mRNA Translation: CAB70709.1
AK001694 mRNA Translation: BAA91841.1 Different initiation.
CCDSiCCDS45769.1 [Q58EX2-1]
PIRiT46428
RefSeqiNP_001138424.1, NM_001144952.1 [Q58EX2-1]
XP_011523216.1, XM_011524914.2 [Q58EX2-3]
UniGeneiHs.435719

Genome annotation databases

EnsembliENST00000392650; ENSP00000376421; ENSG00000069188 [Q58EX2-1]
GeneIDi54549
KEGGihsa:54549
UCSCiuc010dfm.4 human [Q58EX2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSDK2_HUMAN
AccessioniPrimary (citable) accession number: Q58EX2
Secondary accession number(s): A6NMR8
, C9JA57, Q86VY3, Q9NTD2, Q9NVB3, Q9P214
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  5. SIMILARITY comments
    Index of protein domains and families

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