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Entry version 147 (22 Apr 2020)
Sequence version 3 (18 May 2010)
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Protein

Protein sidekick-2

Gene

SDK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373756 SDK interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein sidekick-2By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDK21 PublicationImported
Synonyms:KIAA15141 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:19308 SDK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607217 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q58EX2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1932ExtracellularSequence analysisAdd BLAST1912
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1933 – 1953HelicalSequence analysisAdd BLAST21
Topological domaini1954 – 2172CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54549

Open Targets

More...
OpenTargetsi
ENSG00000069188

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134981456

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q58EX2 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SDK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452966

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022697821 – 2172Protein sidekick-2Add BLAST2152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 91PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi237 ↔ 284PROSITE-ProRule annotation
Disulfide bondi330 ↔ 380PROSITE-ProRule annotation
Disulfide bondi423 ↔ 475PROSITE-ProRule annotation
Disulfide bondi517 ↔ 569PROSITE-ProRule annotation
Glycosylationi609N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi743N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi936N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi948N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1670N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q58EX2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q58EX2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q58EX2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q58EX2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q58EX2

PeptideAtlas

More...
PeptideAtlasi
Q58EX2

PRoteomics IDEntifications database

More...
PRIDEi
Q58EX2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62611 [Q58EX2-1]
62612 [Q58EX2-2]
62613 [Q58EX2-3]
62614 [Q58EX2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q58EX2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q58EX2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000069188 Expressed in cartilage tissue and 178 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q58EX2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q58EX2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000069188 Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion.

Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120034, 20 interactors

Protein interaction database and analysis system

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IntActi
Q58EX2, 18 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000376421

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q58EX2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q58EX2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q58EX2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 108Ig-like C2-type 1Add BLAST83
Domaini113 – 200Ig-like C2-type 2Add BLAST88
Domaini215 – 294Ig-like C2-type 3Add BLAST80
Domaini308 – 396Ig-like C2-type 4Add BLAST89
Domaini402 – 491Ig-like C2-type 5Add BLAST90
Domaini496 – 585Ig-like C2-type 6Add BLAST90
Domaini592 – 688Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini693 – 789Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini794 – 893Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini897 – 991Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini995 – 1094Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100
Domaini1099 – 1197Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST99
Domaini1202 – 1299Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST98
Domaini1303 – 1397Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1402 – 1499Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98
Domaini1504 – 1621Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST118
Domaini1626 – 1722Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST97
Domaini1726 – 1821Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST96
Domaini1824 – 1923Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST100

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2166 – 2172PDZ-bindingBy similarity7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

the PDZ-binding motif mediates interaction with PDZ domain-containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sidekick family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQJJ Eukaryota
ENOG410YMNG LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155761

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001875_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q58EX2

KEGG Orthology (KO)

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KOi
K16353

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYMFSVT

Database of Orthologous Groups

More...
OrthoDBi
134749at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q58EX2

TreeFam database of animal gene trees

More...
TreeFami
TF316846

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 13 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 19 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 13 hits
PF07679 I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 13 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 13 hits
PS50835 IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q58EX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWGLLIWTLL ALHQIRAARA QDDVSPYFKT EPVRTQVHLE GNRLVLTCMA
60 70 80 90 100
EGSWPLEFKW LHNNRELTKF SLEYRYMITS LDRTHAGFYR CIVRNRMGAL
110 120 130 140 150
LQRQTEVQVA YMGSFEEGEK HQSVSHGEAA VIRAPRIASF PQPQVTWFRD
160 170 180 190 200
GRKIPPSSRI AITLENTLVI LSTVAPDAGR YYVQAVNDKN GDNKTSQPIT
210 220 230 240 250
LTVENVGGPA DPIAPTIIIP PKNTSVVAGT SEVTLECVAN ARPLIKLHII
260 270 280 290 300
WKKDGVLLSG GISDHNRRLT IPNPTGSDAG YYECEAVLRS SSVPSVVRGA
310 320 330 340 350
YLSVLEPPQF VKEPERHITA EMEKVVDIPC QAKGVPPPSI TWYKDAAVVE
360 370 380 390 400
VEKLTRFRQR NDGGLQISGL VPDDTGMFQC FARNAAGEVQ TSTYLAVTSI
410 420 430 440 450
APNITRGPLD STVIDGMSVV LACETSGAPR PAITWQKGER ILASGSVQLP
460 470 480 490 500
RFTPLESGSL LISPTHISDA GTYTCLATNS RGVDEASADL VVWARTRITK
510 520 530 540 550
PPQDQSVIKG TQASMVCGVT HDPRVTIRYI WEKDGATLGT ESHPRIRLDR
560 570 580 590 600
NGSLHISQTW SGDIGTYTCR VISAGGNDSR SAHLRVRQLP HAPEHPVATL
610 620 630 640 650
STVERRAINL TWTKPFDGNS PLIRYILEMS ENNAPWTVLL ASVDPKATSV
660 670 680 690 700
TVKGLVPARS YQFRLCAVND VGKGQFSKDT ERVSLPEEPP TAPPQNVIAS
710 720 730 740 750
GRTNQSIMIQ WQPPPESHQN GILKGYIIRY CLAGLPVGYQ FKNITDADVN
760 770 780 790 800
NLLLEDLIIW TNYEIEVAAY NSAGLGVYSS KVTEWTLQGV PTVPPGNVHA
810 820 830 840 850
EATNSTTIRF TWNAPSPQFI NGINQGYKLI AWEPEQEEEV TMVTARPNFQ
860 870 880 890 900
DSIHVGFVSG LKKFTEYFTS VLCFTTPGDG PRSTPQLVRT HEDVPGPVGH
910 920 930 940 950
LSFSEILDTS LKVSWQEPGE KNGILTGYRI SWEEYNRTNT RVTHYLPNVT
960 970 980 990 1000
LEYRVTGLTA LTTYTIEVAA MTSKGQGQVS ASTISSGVPP ELPGPPTNLG
1010 1020 1030 1040 1050
ISNIGPRSVT LQFRPGYDGK TSISRWLVEA QVGVVGEGEE WLLIHQLSNE
1060 1070 1080 1090 1100
PDARSMEVPD LNPFTCYSFR MRQVNIVGTS PPSQPSRKIQ TLQAPPDMAP
1110 1120 1130 1140 1150
ANVSLRTASE TSLWLRWMPL PEMEYNGNPE SVGYKIKYSR SDGHGKTLSH
1160 1170 1180 1190 1200
VVQDRVERDY TIEDLEEWTE YRVQVQAFNA IGSGPWSQTV VGRTRESVPS
1210 1220 1230 1240 1250
SGPTNVSALA TTSSSMLVRW SEVPEADRNG LVLGYKVMYK EKDSDTQPRF
1260 1270 1280 1290 1300
WLVEGNSSRS AQLTGLGKYV LYEVQVLAFT RIGDGSPSHP PILERTLDDV
1310 1320 1330 1340 1350
PGPPMGILFP EVRTTSVRLI WQPPAAPNGI ILAYQITHRL NTTTANTATV
1360 1370 1380 1390 1400
EVLAPSARQY TATGLKPESV YLFRITAQTR KGWGEAAEAL VVTTEKRDRP
1410 1420 1430 1440 1450
QPPSRPMVQQ EDVRARSVLL SWEPGSDGLS PVRYYTIQTR ELPSGRWALH
1460 1470 1480 1490 1500
SASVSHNASS FIVDRLKPFT SYKFRVKATN DIGDSEFSEE SESLTTLQAA
1510 1520 1530 1540 1550
PDEAPTILSV TPHTTTSVLI RWQPPAEDKI NGILLGFRIR YRELLYEGLR
1560 1570 1580 1590 1600
GFTLRGINNP GATWAELTSM YSMRNLSRPS LTQYELDNLN KHRRYEIRMS
1610 1620 1630 1640 1650
VYNAVGEGPS SPPQEVFVGE AVPTAAPRNV VVHGATATQL DVTWEPPPLD
1660 1670 1680 1690 1700
SQNGDIQGYK IYFWEAQRGN LTERVKTLFL AENSVKLKNL TGYTAYMVSV
1710 1720 1730 1740 1750
AAFNAAGDGP RSTPTQGQTQ QAAPSAPSSV KFSELTTTSV NVSWEAPQFP
1760 1770 1780 1790 1800
NGILEGYRLV YEPCSPVDGV SKIVTVDVKG NSPLWLKVKD LAEGVTYRFR
1810 1820 1830 1840 1850
IRAKTFTYGP EIEANVTTGP GEGAPGPPGV PIIVRYSSAI AIHWSSGDPG
1860 1870 1880 1890 1900
KGPITRYVIE ARPSDEGLWD ILIKDIPKEV SSYTFSMDIL KPGVSYDFRV
1910 1920 1930 1940 1950
IAVNDYGFGT PSSPSQSVPA QKANPFYEEW WFLVVIALVG LIFILLLVFV
1960 1970 1980 1990 2000
LIIRGQSKKY AKKTDSGNSA KSGALGHSEM MSLDESSFPA LELNNRRLSV
2010 2020 2030 2040 2050
KNSFCRKNGL YTRSPPRPSP GSLHYSDEDV TKYNDLIPAE SSSLTEKPSE
2060 2070 2080 2090 2100
ISDSQGSDSE YEVDSNHQKA HSFVNHYISD PTYYNSWRRQ QKGISRAQAY
2110 2120 2130 2140 2150
SYTESDSGEP DHTTVTNSTS TQQGSLFRPK ASRTPTPQNP PNPPSQQSTL
2160 2170
YRPPSSLAPG SRAPIAGFSS FV
Length:2,172
Mass (Da):239,396
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CAF9FE659C72A03
GO
Isoform 2 (identifier: Q58EX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1865-1921: DEGLWDILIK...SSPSQSVPAQ → GAPRPAGLRP...EEWETGLGGS
     1922-2172: Missing.

Show »
Length:1,921
Mass (Da):211,180
Checksum:i1788A7BE49FA74D4
GO
Isoform 3 (identifier: Q58EX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1588: SMYSMRNLSRPSLTQYELDN → Y

Show »
Length:2,153
Mass (Da):237,172
Checksum:iCC6B77234A0DF50A
GO
Isoform 4 (identifier: Q58EX2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2156-2172: SLAPGSRAPIAGFSSFV → KAGVQKEGEN...GIWRERGSGG

Show »
Length:2,216
Mass (Da):244,370
Checksum:i0D3DD65A6908A0D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2P2H7C2P2_HUMAN
Protein sidekick-2
SDK2
1,329Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91841 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1218V → G in CAB70709 (PubMed:17974005).Curated1
Sequence conflicti1382G → V in CAB70709 (PubMed:17974005).Curated1
Sequence conflicti1553T → M in AAH45763 (PubMed:15489334).Curated1
Sequence conflicti1553T → M in AAH66363 (PubMed:15489334).Curated1
Sequence conflicti1680L → P in BAA91841 (PubMed:14702039).Curated1
Sequence conflicti2092K → R in BAA91841 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080771376G → S Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs372925045Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0175221569 – 1588SMYSM…YELDN → Y in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0175231865 – 1921DEGLW…SVPAQ → GAPRPAGLRPHSSLSPFFLG PSTWGTCLCPPPEKALVLLQ VKSPGPVEEWETGLGGS in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0175241922 – 2172Missing in isoform 2. 1 PublicationAdd BLAST251
Alternative sequenceiVSP_0175252156 – 2172SLAPG…FSSFV → KAGVQKEGENRERMCVASSS SALRWWGSLLPWELHGAGEV AVSLLWTRSGPGIWRERGSG G in isoform 4. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC032019 Genomic DNA No translation available.
AC087301 Genomic DNA No translation available.
AC124804 Genomic DNA No translation available.
AB040947 mRNA Translation: BAA96038.1
BC045763 mRNA Translation: AAH45763.1
BC066363 mRNA Translation: AAH66363.1
AL137357 mRNA Translation: CAB70709.1
AK001694 mRNA Translation: BAA91841.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45769.1 [Q58EX2-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46428

NCBI Reference Sequences

More...
RefSeqi
NP_001138424.1, NM_001144952.1 [Q58EX2-1]
XP_011523216.1, XM_011524914.2 [Q58EX2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392650; ENSP00000376421; ENSG00000069188 [Q58EX2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54549

UCSC genome browser

More...
UCSCi
uc010dfm.4 human [Q58EX2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Discerning change - Issue 176 of February 2016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC032019 Genomic DNA No translation available.
AC087301 Genomic DNA No translation available.
AC124804 Genomic DNA No translation available.
AB040947 mRNA Translation: BAA96038.1
BC045763 mRNA Translation: AAH45763.1
BC066363 mRNA Translation: AAH66363.1
AL137357 mRNA Translation: CAB70709.1
AK001694 mRNA Translation: BAA91841.1 Different initiation.
CCDSiCCDS45769.1 [Q58EX2-1]
PIRiT46428
RefSeqiNP_001138424.1, NM_001144952.1 [Q58EX2-1]
XP_011523216.1, XM_011524914.2 [Q58EX2-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF5NMR-A580-687[»]
1WFNNMR-A885-990[»]
1WFONMR-A1281-1397[»]
1WISNMR-A983-1093[»]
SMRiQ58EX2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120034, 20 interactors
IntActiQ58EX2, 18 interactors
STRINGi9606.ENSP00000376421

PTM databases

iPTMnetiQ58EX2
PhosphoSitePlusiQ58EX2

Polymorphism and mutation databases

BioMutaiSDK2
DMDMi296452966

Proteomic databases

EPDiQ58EX2
jPOSTiQ58EX2
MassIVEiQ58EX2
MaxQBiQ58EX2
PaxDbiQ58EX2
PeptideAtlasiQ58EX2
PRIDEiQ58EX2
ProteomicsDBi62611 [Q58EX2-1]
62612 [Q58EX2-2]
62613 [Q58EX2-3]
62614 [Q58EX2-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2228 17 antibodies

The DNASU plasmid repository

More...
DNASUi
54549

Genome annotation databases

EnsembliENST00000392650; ENSP00000376421; ENSG00000069188 [Q58EX2-1]
GeneIDi54549
KEGGihsa:54549
UCSCiuc010dfm.4 human [Q58EX2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54549
DisGeNETi54549

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SDK2
HGNCiHGNC:19308 SDK2
HPAiENSG00000069188 Tissue enhanced (testis)
MIMi607217 gene
neXtProtiNX_Q58EX2
OpenTargetsiENSG00000069188
PharmGKBiPA134981456

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQJJ Eukaryota
ENOG410YMNG LUCA
GeneTreeiENSGT00940000155761
HOGENOMiCLU_001875_1_0_1
InParanoidiQ58EX2
KOiK16353
OMAiYYMFSVT
OrthoDBi134749at2759
PhylomeDBiQ58EX2
TreeFamiTF316846

Enzyme and pathway databases

ReactomeiR-HSA-373756 SDK interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SDK2 human
EvolutionaryTraceiQ58EX2

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SDK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54549
PharosiQ58EX2 Tdark

Protein Ontology

More...
PROi
PR:Q58EX2
RNActiQ58EX2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000069188 Expressed in cartilage tissue and 178 other tissues
ExpressionAtlasiQ58EX2 baseline and differential
GenevisibleiQ58EX2 HS

Family and domain databases

CDDicd00063 FN3, 13 hits
Gene3Di2.60.40.10, 19 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 13 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 13 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 7 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 13 hits
PS50835 IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDK2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q58EX2
Secondary accession number(s): A6NMR8
, C9JA57, Q86VY3, Q9NTD2, Q9NVB3, Q9P214
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 18, 2010
Last modified: April 22, 2020
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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