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UniProtKB - Q58EX2 (SDK2_HUMAN)

Entry version 151 (02 Dec 2020)
Sequence version 3 (18 May 2010)
Previous versions | rss
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Protein

Protein sidekick-2

Gene

SDK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q58EX2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-373756, SDK interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein sidekick-2By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDK21 PublicationImported
Synonyms:KIAA15141 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000069188.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:19308, SDK2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607217, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q58EX2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1932ExtracellularSequence analysisAdd BLAST1912
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1933 – 1953HelicalSequence analysisAdd BLAST21
Topological domaini1954 – 2172CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54549

Open Targets

More...OpenTargetsi		ENSG00000069188

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134981456

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q58EX2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SDK2

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452966

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022697821 – 2172Protein sidekick-2Add BLAST2152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 91PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi237 ↔ 284PROSITE-ProRule annotation
Disulfide bondi330 ↔ 380PROSITE-ProRule annotation
Disulfide bondi423 ↔ 475PROSITE-ProRule annotation
Disulfide bondi517 ↔ 569PROSITE-ProRule annotation
Glycosylationi609N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi743N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi936N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi948N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1670N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q58EX2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q58EX2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q58EX2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q58EX2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q58EX2

PeptideAtlas

More...PeptideAtlasi		Q58EX2

PRoteomics IDEntifications database

More...PRIDEi		Q58EX2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62611 [Q58EX2-1]
62612 [Q58EX2-2]
62613 [Q58EX2-3]
62614 [Q58EX2-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q58EX2, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q58EX2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q58EX2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000069188, Expressed in cartilage tissue and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q58EX2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q58EX2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000069188, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion.

Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120034, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q58EX2, 18 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376421

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q58EX2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q58EX2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q58EX2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 108Ig-like C2-type 1Add BLAST83
Domaini113 – 200Ig-like C2-type 2Add BLAST88
Domaini215 – 294Ig-like C2-type 3Add BLAST80
Domaini308 – 396Ig-like C2-type 4Add BLAST89
Domaini402 – 491Ig-like C2-type 5Add BLAST90
Domaini496 – 585Ig-like C2-type 6Add BLAST90
Domaini592 – 688Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini693 – 789Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini794 – 893Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini897 – 991Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini995 – 1094Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100
Domaini1099 – 1197Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST99
Domaini1202 – 1299Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST98
Domaini1303 – 1397Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1402 – 1499Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98
Domaini1504 – 1621Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST118
Domaini1626 – 1722Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST97
Domaini1726 – 1821Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST96
Domaini1824 – 1923Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST100

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2166 – 2172PDZ-bindingBy similarity7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

the PDZ-binding motif mediates interaction with PDZ domain-containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sidekick family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3510, Eukaryota
KOG4221, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155761

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001875_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q58EX2

Identification of Orthologs from Complete Genome Data

More...OMAi		DKYTEYR

Database of Orthologous Groups

More...OrthoDBi		134749at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q58EX2

TreeFam database of animal gene trees

More...TreeFami		TF316846

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 13 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 19 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 13 hits
PF07679, I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 13 hits
SM00409, IG, 6 hits
SM00408, IGc2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 13 hits
PS50835, IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q58EX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWGLLIWTLL ALHQIRAARA QDDVSPYFKT EPVRTQVHLE GNRLVLTCMA 
        60         70         80         90        100
EGSWPLEFKW LHNNRELTKF SLEYRYMITS LDRTHAGFYR CIVRNRMGAL 
       110        120        130        140        150
LQRQTEVQVA YMGSFEEGEK HQSVSHGEAA VIRAPRIASF PQPQVTWFRD 
       160        170        180        190        200
GRKIPPSSRI AITLENTLVI LSTVAPDAGR YYVQAVNDKN GDNKTSQPIT 
       210        220        230        240        250
LTVENVGGPA DPIAPTIIIP PKNTSVVAGT SEVTLECVAN ARPLIKLHII 
       260        270        280        290        300
WKKDGVLLSG GISDHNRRLT IPNPTGSDAG YYECEAVLRS SSVPSVVRGA 
       310        320        330        340        350
YLSVLEPPQF VKEPERHITA EMEKVVDIPC QAKGVPPPSI TWYKDAAVVE 
       360        370        380        390        400
VEKLTRFRQR NDGGLQISGL VPDDTGMFQC FARNAAGEVQ TSTYLAVTSI 
       410        420        430        440        450
APNITRGPLD STVIDGMSVV LACETSGAPR PAITWQKGER ILASGSVQLP 
       460        470        480        490        500
RFTPLESGSL LISPTHISDA GTYTCLATNS RGVDEASADL VVWARTRITK 
       510        520        530        540        550
PPQDQSVIKG TQASMVCGVT HDPRVTIRYI WEKDGATLGT ESHPRIRLDR 
       560        570        580        590        600
NGSLHISQTW SGDIGTYTCR VISAGGNDSR SAHLRVRQLP HAPEHPVATL 
       610        620        630        640        650
STVERRAINL TWTKPFDGNS PLIRYILEMS ENNAPWTVLL ASVDPKATSV 
       660        670        680        690        700
TVKGLVPARS YQFRLCAVND VGKGQFSKDT ERVSLPEEPP TAPPQNVIAS 
       710        720        730        740        750
GRTNQSIMIQ WQPPPESHQN GILKGYIIRY CLAGLPVGYQ FKNITDADVN 
       760        770        780        790        800
NLLLEDLIIW TNYEIEVAAY NSAGLGVYSS KVTEWTLQGV PTVPPGNVHA 
       810        820        830        840        850
EATNSTTIRF TWNAPSPQFI NGINQGYKLI AWEPEQEEEV TMVTARPNFQ 
       860        870        880        890        900
DSIHVGFVSG LKKFTEYFTS VLCFTTPGDG PRSTPQLVRT HEDVPGPVGH 
       910        920        930        940        950
LSFSEILDTS LKVSWQEPGE KNGILTGYRI SWEEYNRTNT RVTHYLPNVT 
       960        970        980        990       1000
LEYRVTGLTA LTTYTIEVAA MTSKGQGQVS ASTISSGVPP ELPGPPTNLG 
      1010       1020       1030       1040       1050
ISNIGPRSVT LQFRPGYDGK TSISRWLVEA QVGVVGEGEE WLLIHQLSNE 
      1060       1070       1080       1090       1100
PDARSMEVPD LNPFTCYSFR MRQVNIVGTS PPSQPSRKIQ TLQAPPDMAP 
      1110       1120       1130       1140       1150
ANVSLRTASE TSLWLRWMPL PEMEYNGNPE SVGYKIKYSR SDGHGKTLSH 
      1160       1170       1180       1190       1200
VVQDRVERDY TIEDLEEWTE YRVQVQAFNA IGSGPWSQTV VGRTRESVPS 
      1210       1220       1230       1240       1250
SGPTNVSALA TTSSSMLVRW SEVPEADRNG LVLGYKVMYK EKDSDTQPRF 
      1260       1270       1280       1290       1300
WLVEGNSSRS AQLTGLGKYV LYEVQVLAFT RIGDGSPSHP PILERTLDDV 
      1310       1320       1330       1340       1350
PGPPMGILFP EVRTTSVRLI WQPPAAPNGI ILAYQITHRL NTTTANTATV 
      1360       1370       1380       1390       1400
EVLAPSARQY TATGLKPESV YLFRITAQTR KGWGEAAEAL VVTTEKRDRP 
      1410       1420       1430       1440       1450
QPPSRPMVQQ EDVRARSVLL SWEPGSDGLS PVRYYTIQTR ELPSGRWALH 
      1460       1470       1480       1490       1500
SASVSHNASS FIVDRLKPFT SYKFRVKATN DIGDSEFSEE SESLTTLQAA 
      1510       1520       1530       1540       1550
PDEAPTILSV TPHTTTSVLI RWQPPAEDKI NGILLGFRIR YRELLYEGLR 
      1560       1570       1580       1590       1600
GFTLRGINNP GATWAELTSM YSMRNLSRPS LTQYELDNLN KHRRYEIRMS 
      1610       1620       1630       1640       1650
VYNAVGEGPS SPPQEVFVGE AVPTAAPRNV VVHGATATQL DVTWEPPPLD 
      1660       1670       1680       1690       1700
SQNGDIQGYK IYFWEAQRGN LTERVKTLFL AENSVKLKNL TGYTAYMVSV 
      1710       1720       1730       1740       1750
AAFNAAGDGP RSTPTQGQTQ QAAPSAPSSV KFSELTTTSV NVSWEAPQFP 
      1760       1770       1780       1790       1800
NGILEGYRLV YEPCSPVDGV SKIVTVDVKG NSPLWLKVKD LAEGVTYRFR 
      1810       1820       1830       1840       1850
IRAKTFTYGP EIEANVTTGP GEGAPGPPGV PIIVRYSSAI AIHWSSGDPG 
      1860       1870       1880       1890       1900
KGPITRYVIE ARPSDEGLWD ILIKDIPKEV SSYTFSMDIL KPGVSYDFRV 
      1910       1920       1930       1940       1950
IAVNDYGFGT PSSPSQSVPA QKANPFYEEW WFLVVIALVG LIFILLLVFV 
      1960       1970       1980       1990       2000
LIIRGQSKKY AKKTDSGNSA KSGALGHSEM MSLDESSFPA LELNNRRLSV 
      2010       2020       2030       2040       2050
KNSFCRKNGL YTRSPPRPSP GSLHYSDEDV TKYNDLIPAE SSSLTEKPSE 
      2060       2070       2080       2090       2100
ISDSQGSDSE YEVDSNHQKA HSFVNHYISD PTYYNSWRRQ QKGISRAQAY 
      2110       2120       2130       2140       2150
SYTESDSGEP DHTTVTNSTS TQQGSLFRPK ASRTPTPQNP PNPPSQQSTL 
      2160       2170 
YRPPSSLAPG SRAPIAGFSS FV
Length:2,172
Mass (Da):239,396
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CAF9FE659C72A03
GO
Isoform 2 (identifier: Q58EX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1865-1921: DEGLWDILIK...SSPSQSVPAQ → GAPRPAGLRP...EEWETGLGGS
     1922-2172: Missing.

Show »
Length:1,921
Mass (Da):211,180
Checksum:i1788A7BE49FA74D4
GO
Isoform 3 (identifier: Q58EX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1588: SMYSMRNLSRPSLTQYELDN → Y

Show »
Length:2,153
Mass (Da):237,172
Checksum:iCC6B77234A0DF50A
GO
Isoform 4 (identifier: Q58EX2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2156-2172: SLAPGSRAPIAGFSSFV → KAGVQKEGEN...GIWRERGSGG

Show »
Length:2,216
Mass (Da):244,370
Checksum:i0D3DD65A6908A0D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2P2H7C2P2_HUMAN
Protein sidekick-2
SDK2
1,329Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91841 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1218V → G in CAB70709 (PubMed:17974005).Curated1
Sequence conflicti1382G → V in CAB70709 (PubMed:17974005).Curated1
Sequence conflicti1553T → M in AAH45763 (PubMed:15489334).Curated1
Sequence conflicti1553T → M in AAH66363 (PubMed:15489334).Curated1
Sequence conflicti1680L → P in BAA91841 (PubMed:14702039).Curated1
Sequence conflicti2092K → R in BAA91841 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080771376G → S Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs372925045Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0175221569 – 1588SMYSM…YELDN → Y in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0175231865 – 1921DEGLW…SVPAQ → GAPRPAGLRPHSSLSPFFLG PSTWGTCLCPPPEKALVLLQ VKSPGPVEEWETGLGGS in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0175241922 – 2172Missing in isoform 2. 1 PublicationAdd BLAST251
Alternative sequenceiVSP_0175252156 – 2172SLAPG…FSSFV → KAGVQKEGENRERMCVASSS SALRWWGSLLPWELHGAGEV AVSLLWTRSGPGIWRERGSG G in isoform 4. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC032019 Genomic DNA No translation available.
AC087301 Genomic DNA No translation available.
AC124804 Genomic DNA No translation available.
AB040947 mRNA Translation: BAA96038.1
BC045763 mRNA Translation: AAH45763.1
BC066363 mRNA Translation: AAH66363.1
AL137357 mRNA Translation: CAB70709.1
AK001694 mRNA Translation: BAA91841.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45769.1 [Q58EX2-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T46428

NCBI Reference Sequences

More...RefSeqi		NP_001138424.1, NM_001144952.1 [Q58EX2-1]
XP_011523216.1, XM_011524914.2 [Q58EX2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000392650; ENSP00000376421; ENSG00000069188 [Q58EX2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54549

UCSC genome browser

More...UCSCi		uc010dfm.4, human [Q58EX2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Discerning change - Issue 176 of February 2016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC032019 Genomic DNA No translation available.
AC087301 Genomic DNA No translation available.
AC124804 Genomic DNA No translation available.
AB040947 mRNA Translation: BAA96038.1
BC045763 mRNA Translation: AAH45763.1
BC066363 mRNA Translation: AAH66363.1
AL137357 mRNA Translation: CAB70709.1
AK001694 mRNA Translation: BAA91841.1 Different initiation.
CCDSiCCDS45769.1 [Q58EX2-1]
PIRiT46428
RefSeqiNP_001138424.1, NM_001144952.1 [Q58EX2-1]
XP_011523216.1, XM_011524914.2 [Q58EX2-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF5NMR-A580-687[»]
1WFNNMR-A885-990[»]
1WFONMR-A1281-1397[»]
1WISNMR-A983-1093[»]
SMRiQ58EX2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120034, 21 interactors
IntActiQ58EX2, 18 interactors
STRINGi9606.ENSP00000376421

PTM databases

GlyGeniQ58EX2, 7 sites
iPTMnetiQ58EX2
PhosphoSitePlusiQ58EX2

Polymorphism and mutation databases

BioMutaiSDK2
DMDMi296452966

Proteomic databases

EPDiQ58EX2
jPOSTiQ58EX2
MassIVEiQ58EX2
MaxQBiQ58EX2
PaxDbiQ58EX2
PeptideAtlasiQ58EX2
PRIDEiQ58EX2
ProteomicsDBi62611 [Q58EX2-1]
62612 [Q58EX2-2]
62613 [Q58EX2-3]
62614 [Q58EX2-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2228, 17 antibodies

The DNASU plasmid repository

More...DNASUi		54549

Genome annotation databases

EnsembliENST00000392650; ENSP00000376421; ENSG00000069188 [Q58EX2-1]
GeneIDi54549
KEGGihsa:54549
UCSCiuc010dfm.4, human [Q58EX2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54549
DisGeNETi54549
EuPathDBiHostDB:ENSG00000069188.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		SDK2
HGNCiHGNC:19308, SDK2
HPAiENSG00000069188, Tissue enhanced (testis)
MIMi607217, gene
neXtProtiNX_Q58EX2
OpenTargetsiENSG00000069188
PharmGKBiPA134981456

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3510, Eukaryota
KOG4221, Eukaryota
GeneTreeiENSGT00940000155761
HOGENOMiCLU_001875_1_0_1
InParanoidiQ58EX2
OMAiDKYTEYR
OrthoDBi134749at2759
PhylomeDBiQ58EX2
TreeFamiTF316846

Enzyme and pathway databases

PathwayCommonsiQ58EX2
ReactomeiR-HSA-373756, SDK interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54549, 5 hits in 839 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SDK2, human
EvolutionaryTraceiQ58EX2

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SDK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54549
PharosiQ58EX2, Tdark

Protein Ontology

More...PROi		PR:Q58EX2
RNActiQ58EX2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000069188, Expressed in cartilage tissue and 201 other tissues
ExpressionAtlasiQ58EX2, baseline and differential
GenevisibleiQ58EX2, HS

Family and domain databases

CDDicd00063, FN3, 13 hits
Gene3Di2.60.40.10, 19 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
PfamiView protein in Pfam
PF00041, fn3, 13 hits
PF07679, I-set, 3 hits
SMARTiView protein in SMART
SM00060, FN3, 13 hits
SM00409, IG, 6 hits
SM00408, IGc2, 6 hits
SUPFAMiSSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 7 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 13 hits
PS50835, IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDK2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q58EX2
Secondary accession number(s): A6NMR8
, C9JA57, Q86VY3, Q9NTD2, Q9NVB3, Q9P214
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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