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Entry version 131 (07 Oct 2020)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

Zgc:113099

Gene

trim2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zgc:113099Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trim2aImported
Synonyms:zgc:113099Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050327-99, trim2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 64RING-typeInterPro annotationAdd BLAST42
Domaini112 – 153B box-typeInterPro annotationAdd BLAST42
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati319 – 421FilaminPROSITE-ProRule annotationAdd BLAST103
Repeati473 – 516NHLPROSITE-ProRule annotationAdd BLAST44
Repeati520 – 563NHLPROSITE-ProRule annotationAdd BLAST44
Repeati564 – 605NHLPROSITE-ProRule annotationAdd BLAST42
Repeati609 – 652NHLPROSITE-ProRule annotationAdd BLAST44
Repeati658 – 699NHLPROSITE-ProRule annotationAdd BLAST42
Repeati700 – 743NHLPROSITE-ProRule annotationAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili154 – 202Sequence analysisAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K11997

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q58ER5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021, BBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 2 hits
2.60.40.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR003649, Bbox_C
IPR017868, Filamin/ABP280_repeat-like
IPR001298, Filamin/ABP280_rpt
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR001258, NHL_repeat
IPR013017, NHL_repeat_subgr
IPR027370, Znf-RING_LisH
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00630, Filamin, 1 hit
PF01436, NHL, 6 hits
PF00643, zf-B_box, 1 hit
PF13445, zf-RING_UBOX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00502, BBC, 1 hit
SM00336, BBOX, 1 hit
SM00557, IG_FLMN, 1 hit
SM00184, RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50194, FILAMIN_REPEAT, 1 hit
PS51125, NHL, 6 hits
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q58ER5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATDASTLPS PVVRQIDKQF LICSICLDRY NNPKVLPCLH TFCERCLQNY
60 70 80 90 100
IPPHSLTLSC PVCRQTSILP EKGVAALQSN FFITNLMEVL KKSPNSNLSE
110 120 130 140 150
DYTDAINGVA TGQPLSCPNH GGNVMEFYCP PCETAMCEEC TSGEHAEHAT
160 170 180 190 200
VPLKDVLEQH KASLQEQLDA VKNRLPEIES ALEVLSEILQ QLSSQKSSIE
210 220 230 240 250
EMIHATFEEL QKTLNVRKSV LLMELEVNYG LKQKVLQTQL ESLLQGQDGI
260 270 280 290 300
RSSCSFTEQA LNHGSEAEVL LVKKQMSERL DELANQELPL RPEENNQLDF
310 320 330 340 350
LVETDGLRKS IHNLGAIVTT NAVAAETVAT GEGLRHCIVG QLTSVTVTTK
360 370 380 390 400
DRDGGLCRTG NALLIADLSA IDGSIVGEGK VTDHKNGTYE FVYSVPCEGR
410 420 430 440 450
FTLTLKLYDQ HIRGSPFSIR ANKPTDISLT ADVDKKRLKS PGNSHVKQRA
460 470 480 490 500
IKRPASMYST GKRKENPIED DLIFRIGTKG RNKGEFTNLQ GVAASSVGKV
510 520 530 540 550
LIADSNNQCV QIFLNDGQFK GRFGIRGRSP GQLQRPTGVA VHPSGDIIIA
560 570 580 590 600
DYDNKWVSIF SSDGKFKSKI GSGKLMGPKG VSVDRNGHII VVDNKSCCVF
610 620 630 640 650
IFQPNGKLVS KFGNRGNSDK QFAGPHFAAV NQNNEVIVTD FHNHSVKVFS
660 670 680 690 700
PEGEFILKFG SNGEGNGQFN APTGVAVDAN GNIIVADWGN SRIQVFDSSG
710 720 730 740
SFLSYINTSA DPLYGPQGLA LTSDGHVVVA DSGNHCFKVY RYLQ
Length:744
Mass (Da):81,232
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i658B3A863868C92B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC091789 mRNA Translation: AAH91789.1

NCBI Reference Sequences

More...
RefSeqi
NP_001014393.1, NM_001014371.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100003782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:100003782

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091789 mRNA Translation: AAH91789.1
RefSeqiNP_001014393.1, NM_001014371.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi100003782
KEGGidre:100003782

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100003782
ZFINiZDB-GENE-050327-99, trim2a

Phylogenomic databases

KOiK11997
PhylomeDBiQ58ER5

Family and domain databases

CDDicd00021, BBOX, 1 hit
Gene3Di2.120.10.30, 2 hits
2.60.40.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR003649, Bbox_C
IPR017868, Filamin/ABP280_repeat-like
IPR001298, Filamin/ABP280_rpt
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR001258, NHL_repeat
IPR013017, NHL_repeat_subgr
IPR027370, Znf-RING_LisH
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF00630, Filamin, 1 hit
PF01436, NHL, 6 hits
PF00643, zf-B_box, 1 hit
PF13445, zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00502, BBC, 1 hit
SM00336, BBOX, 1 hit
SM00557, IG_FLMN, 1 hit
SM00184, RING, 1 hit
SUPFAMiSSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50194, FILAMIN_REPEAT, 1 hit
PS51125, NHL, 6 hits
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ58ER5_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q58ER5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 7, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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