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Protein

Probable palmitoyltransferase ZDHHC4

Gene

ZDHHC4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC4 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 4
Short name:
DHHC-4
Gene namesi
Name:ZDHHC4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128641 – 343Probable palmitoyltransferase ZDHHC4Add BLAST343

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ58DT3

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012560

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 199DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1312 Eukaryota
COG5273 LUCA
HOVERGENiHBG054775
InParanoidiQ58DT3
KOiK20003

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q58DT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLVLFLLY LALVLLGFVM ICIGSKTHYL QGLISRGAQV FSYIIPECLQ
60 70 80 90 100
RAMLSVLHYL FHTRNYTFVV LHLILQGMVY TEYTWEIFGL CQQLEFSLYY
110 120 130 140 150
LFLPYLLLIV NLLFFTLSCV TNPGTITKAN ELLFLQVYEF DGVMFPKNVR
160 170 180 190 200
CPTCDLRKPA RSKHCSVCNR CVHRFDHHCV WVNNCIGAWN TRYFLSYLFT
210 220 230 240 250
LTASAATMAV VSTVFLVRLV VMSDVYLQTY VDDLGHLQVV DTVFLVQYLF
260 270 280 290 300
LTFPRIVFLV GFVVVLSFLL GGYLCFCLYL AATNQTTNEW YKGDRAWCQH
310 320 330 340
CPHVARPPAA EPQAYRNIHS HGLWSNLREI FLPATACYER KEK
Length:343
Mass (Da):39,710
Last modified:April 26, 2005 - v1
Checksum:i6FF48DFEAE05A22F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021514 mRNA Translation: AAX46361.1
RefSeqiNP_001030369.1, NM_001035292.1
UniGeneiBt.4145

Genome annotation databases

GeneIDi514338
KEGGibta:514338

Similar proteinsi

Entry informationi

Entry nameiZDHC4_BOVIN
AccessioniPrimary (citable) accession number: Q58DT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: April 26, 2005
Last modified: December 20, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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