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UniProtKB - Q58DN7 (ACSF3_BOVIN)
Protein
Malonate--CoA ligase ACSF3, mitochondrial
Gene
ACSF3
Organism
Bos taurus (Bovine)
Status
Functioni
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
By similarityCatalytic activityi
- This reaction proceeds in the forwardBy similarity direction.
- EC:6.2.1.n3By similarityThis reaction proceeds in the forwardBy similarity direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 457 | ATPBy similarity | 1 | |
Binding sitei | 471 | ATPBy similarity | 1 | |
Binding sitei | 563 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 203 – 211 | ATPBy similarity | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- CoA-ligase activity Source: GO_Central
- malonyl-CoA synthetase activity Source: RHEA
- very long-chain fatty acid-CoA ligase activity Source: GO_Central
GO - Biological processi
- fatty acid biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Malonate--CoA ligase ACSF3, mitochondrialBy similarity (EC:6.2.1.n3By similarity)Alternative name(s): Acyl-CoA synthetase family member 3 |
Gene namesi | Name:ACSF3By similarity |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000015968 |
VGNCi | VGNC:25563, ACSF3 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 89 | MitochondrionSequence analysisAdd BLAST | 89 | |
ChainiPRO_0000315799 | 90 – 586 | Malonate--CoA ligase ACSF3, mitochondrialAdd BLAST | 497 |
Proteomic databases
PaxDbi | Q58DN7 |
PRIDEi | Q58DN7 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000015968, Expressed in testis and 99 other tissues |
ExpressionAtlasi | Q58DN7, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1176, Eukaryota |
GeneTreei | ENSGT00940000157000 |
HOGENOMi | CLU_000022_59_11_1 |
InParanoidi | Q58DN7 |
OrthoDBi | 533939at2759 |
TreeFami | TF312995 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q58DN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLPYVGMAL RRLAWAVASC RLAPWTRGAS GPLHSAPAAR SDCSAPVFIR
60 70 80 90 100
APAFGDRLAL IDQHGRHTYK DLYLRSLRLS REICQLRACA DGDLREERVS
110 120 130 140 150
LLCSNDVSFV VAQWAAWMSG GVAVPLYRKH PRAQLEYFIQ DSRSSVVLAG
160 170 180 190 200
PEHVELLSPV AQKLGVPLLP LPPTVYHGVA EDPEEGLVLE RNWRDRGAMI
210 220 230 240 250
IYTSGTTGRP KGVLSTHDNI RAVVTGLVHK WAWTKDDVIL HVLPLHHVHG
260 270 280 290 300
VVNKLLCPLW VGATCVMLPE FSAQLVWEKF LSSEAPQINV FMAVPTIYSK
310 320 330 340 350
LMDYYDKHFT QPHVQDFVRA VCEEKIRLMV SGSAALPLPV LEKWKGITGH
360 370 380 390 400
TLLERYGMTE IGMALSNPLT AARLPGSVGT PLPGVEVRIV SENPQKDSSP
410 420 430 440 450
YLIHAEGSEE NTKVTPGFEE KEGELLVRGP SVFREYWDKP EETKAAFTSD
460 470 480 490 500
GWFKTGDTVV FKDGCYWIRG RTSVDIIKSG GYKVSALEVE RLLLAHPSIT
510 520 530 540 550
DVAVIGVPDM TWGQRVTAVV TLQEGHSLSH RELKEWARGV LAPYAVPSEL
560 570 580
LLVEEIPRNQ MGKVNKRDLV RQLYPHEKGA PEAGSQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MX65 | A0A3Q1MX65_BOVIN | Malonate--CoA ligase ACSF3, mitocho... | ACSF3 | 630 | Annotation score: | ||
A0A3Q1LS82 | A0A3Q1LS82_BOVIN | Malonate--CoA ligase ACSF3, mitocho... | ACSF3 | 580 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021560 mRNA Translation: AAX46407.1 BC102586 mRNA Translation: AAI02587.1 |
RefSeqi | NP_001030240.1, NM_001035068.2 XP_005218566.1, XM_005218509.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021560 mRNA Translation: AAX46407.1 BC102586 mRNA Translation: AAI02587.1 |
RefSeqi | NP_001030240.1, NM_001035068.2 XP_005218566.1, XM_005218509.3 |
3D structure databases
AlphaFoldDBi | Q58DN7 |
SMRi | Q58DN7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000021234 |
Proteomic databases
PaxDbi | Q58DN7 |
PRIDEi | Q58DN7 |
Genome annotation databases
Organism-specific databases
CTDi | 197322 |
VEuPathDBi | HostDB:ENSBTAG00000015968 |
VGNCi | VGNC:25563, ACSF3 |
Phylogenomic databases
eggNOGi | KOG1176, Eukaryota |
GeneTreei | ENSGT00940000157000 |
HOGENOMi | CLU_000022_59_11_1 |
InParanoidi | Q58DN7 |
OrthoDBi | 533939at2759 |
TreeFami | TF312995 |
Gene expression databases
Bgeei | ENSBTAG00000015968, Expressed in testis and 99 other tissues |
ExpressionAtlasi | Q58DN7, baseline and differential |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACSF3_BOVIN | |
Accessioni | Q58DN7Primary (citable) accession number: Q58DN7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | April 26, 2005 | |
Last modified: | May 25, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families