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Protein

Acyl-CoA synthetase family member 3, mitochondrial

Gene

ACSF3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei457ATPBy similarity1
Binding sitei471ATPBy similarity1
Binding sitei563ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 211ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-75876 Synthesis of very long-chain fatty acyl-CoAs

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA synthetase family member 3, mitochondrial (EC:6.2.1.-)
Gene namesi
Name:ACSF3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:25563 ACSF3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 89MitochondrionSequence analysisAdd BLAST89
ChainiPRO_000031579990 – 586Acyl-CoA synthetase family member 3, mitochondrialAdd BLAST497

Proteomic databases

PaxDbiQ58DN7
PRIDEiQ58DN7

Expressioni

Gene expression databases

BgeeiENSBTAG00000015968

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021234

Structurei

3D structure databases

ProteinModelPortaliQ58DN7
SMRiQ58DN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1176 Eukaryota
COG0318 LUCA
GeneTreeiENSGT00760000119304
HOGENOMiHOG000229983
HOVERGENiHBG100430
InParanoidiQ58DN7
KOiK18660
OMAiVENSYDY
OrthoDBiEOG091G0427
TreeFamiTF312995

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58DN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPYVGMAL RRLAWAVASC RLAPWTRGAS GPLHSAPAAR SDCSAPVFIR
60 70 80 90 100
APAFGDRLAL IDQHGRHTYK DLYLRSLRLS REICQLRACA DGDLREERVS
110 120 130 140 150
LLCSNDVSFV VAQWAAWMSG GVAVPLYRKH PRAQLEYFIQ DSRSSVVLAG
160 170 180 190 200
PEHVELLSPV AQKLGVPLLP LPPTVYHGVA EDPEEGLVLE RNWRDRGAMI
210 220 230 240 250
IYTSGTTGRP KGVLSTHDNI RAVVTGLVHK WAWTKDDVIL HVLPLHHVHG
260 270 280 290 300
VVNKLLCPLW VGATCVMLPE FSAQLVWEKF LSSEAPQINV FMAVPTIYSK
310 320 330 340 350
LMDYYDKHFT QPHVQDFVRA VCEEKIRLMV SGSAALPLPV LEKWKGITGH
360 370 380 390 400
TLLERYGMTE IGMALSNPLT AARLPGSVGT PLPGVEVRIV SENPQKDSSP
410 420 430 440 450
YLIHAEGSEE NTKVTPGFEE KEGELLVRGP SVFREYWDKP EETKAAFTSD
460 470 480 490 500
GWFKTGDTVV FKDGCYWIRG RTSVDIIKSG GYKVSALEVE RLLLAHPSIT
510 520 530 540 550
DVAVIGVPDM TWGQRVTAVV TLQEGHSLSH RELKEWARGV LAPYAVPSEL
560 570 580
LLVEEIPRNQ MGKVNKRDLV RQLYPHEKGA PEAGSQ
Length:586
Mass (Da):64,990
Last modified:April 26, 2005 - v1
Checksum:i5D45A8D1D4C07992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021560 mRNA Translation: AAX46407.1
BC102586 mRNA Translation: AAI02587.1
RefSeqiNP_001030240.1, NM_001035068.2
XP_005218566.1, XM_005218509.3
UniGeneiBt.49591

Genome annotation databases

EnsembliENSBTAT00000021234; ENSBTAP00000021234; ENSBTAG00000015968
GeneIDi509209
KEGGibta:509209

Similar proteinsi

Entry informationi

Entry nameiACSF3_BOVIN
AccessioniPrimary (citable) accession number: Q58DN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 26, 2005
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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