UniProtKB - Q58DH7 (SGMR1_BOVIN)
Sigma non-opioid intracellular receptor 1
SIGMAR1
Functioni
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity).
Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).
By similarityMiscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 126 | Important for ligand bindingBy similarity | 1 | |
Sitei | 172 | Important for ligand bindingBy similarity | 1 |
GO - Biological processi
- cell death in response to hydrogen peroxide Source: UniProtKB
- lipid transport Source: UniProtKB-KW
- regulation of neuron apoptotic process Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Lipid transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Sigma non-opioid intracellular receptor 1Alternative name(s): Sigma 1-type opioid receptor Short name: Sigma1-receptor Short name: Sigma1R |
Gene namesi | Name:SIGMAR1 Synonyms:OPRS1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000015804 |
VGNCi | VGNC:34619, SIGMAR1 |
Subcellular locationi
Nucleus
- Nucleus inner membrane By similarity
- Nucleus outer membrane By similarity
- Nucleus envelope By similarity
Plasma membrane
- Cell membrane By similarity
- postsynaptic density membrane By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity
Other locations
- Cytoplasmic vesicle By similarity
- Membrane By similarity; Single-pass membrane protein By similarity
- Lipid droplet By similarity
- Cell junction By similarity
- growth cone By similarity
Note: During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis. Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum (By similarity). Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (By similarity).By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nuclear inner membrane Source: UniProtKB-SubCell
- nuclear outer membrane Source: UniProtKB-SubCell
Plasma Membrane
- postsynaptic density membrane Source: UniProtKB-SubCell
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
- growth cone Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB
- lipid droplet Source: UniProtKB-SubCell
- postsynaptic density Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | LumenalBy similarity | 9 | |
Transmembranei | 10 – 30 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 31 – 223 | CytoplasmicBy similarityAdd BLAST | 193 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Lipid droplet, Membrane, Nucleus, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000268650 | 1 – 223 | Sigma non-opioid intracellular receptor 1Add BLAST | 223 |
Proteomic databases
PaxDbi | Q58DH7 |
PRIDEi | Q58DH7 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000015804, Expressed in diaphragm and 93 other tissues |
ExpressionAtlasi | Q58DH7, baseline and differential |
Interactioni
Subunit structurei
Homotrimer.
Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists.
Interacts with KCNA4.
Interacts with KCNA2; cocaine consumption leads to increased interaction.
Interacts with RNF112 in an oxidative stress-regulated manner.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000020990 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 8 | Targeting to endoplasmic reticulum-associated lipid dropletsBy similarity | 7 | |
Regioni | 99 – 106 | Important for ligand-bindingBy similarity | 8 | |
Regioni | 177 – 223 | C-terminal hydrophobic regionCuratedAdd BLAST | 47 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4143, Eukaryota |
GeneTreei | ENSGT00390000012082 |
HOGENOMi | CLU_085469_0_0_1 |
InParanoidi | Q58DH7 |
OMAi | QFYIFDP |
OrthoDBi | 1285317at2759 |
TreeFami | TF300106 |
Family and domain databases
InterProi | View protein in InterPro IPR006716, ERG2_sigma1_rcpt-like |
PANTHERi | PTHR10868, PTHR10868, 1 hit |
Pfami | View protein in Pfam PF04622, ERG2_Sigma1R, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MCWAVGRRWA WAALLLAVAA VLAQVVWLWL GTQSFVFQHE EIAQLARQYA
60 70 80 90 100
GLDHELAFSR LIVELRRLHP GHVLPDEDLQ WVFVNAGGWM GAMCLLHASL
110 120 130 140 150
SEYVLLFGTA LGSSGHSGRY WAEISDTIIS GTFHQWREGT TKSEVFYPGE
160 170 180 190 200
TVVHGPGEAT AVEWGPNTWM VEYGRGVIPS TLGFALADTV FSTQDFLTLF
210 220
YTLRAYARGL RLELTTYLFG QDA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1LZK8 | A0A3Q1LZK8_BOVIN | Sigma non-opioid intracellular rece... | SIGMAR1 | 267 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021620 mRNA Translation: AAX46467.1 |
RefSeqi | NP_001029827.1, NM_001034655.1 |
Genome annotation databases
Ensembli | ENSBTAT00000020990; ENSBTAP00000020990; ENSBTAG00000015804 |
GeneIDi | 538903 |
KEGGi | bta:538903 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021620 mRNA Translation: AAX46467.1 |
RefSeqi | NP_001029827.1, NM_001034655.1 |
3D structure databases
SMRi | Q58DH7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000020990 |
Proteomic databases
PaxDbi | Q58DH7 |
PRIDEi | Q58DH7 |
Genome annotation databases
Ensembli | ENSBTAT00000020990; ENSBTAP00000020990; ENSBTAG00000015804 |
GeneIDi | 538903 |
KEGGi | bta:538903 |
Organism-specific databases
CTDi | 10280 |
VEuPathDBi | HostDB:ENSBTAG00000015804 |
VGNCi | VGNC:34619, SIGMAR1 |
Phylogenomic databases
eggNOGi | KOG4143, Eukaryota |
GeneTreei | ENSGT00390000012082 |
HOGENOMi | CLU_085469_0_0_1 |
InParanoidi | Q58DH7 |
OMAi | QFYIFDP |
OrthoDBi | 1285317at2759 |
TreeFami | TF300106 |
Gene expression databases
Bgeei | ENSBTAG00000015804, Expressed in diaphragm and 93 other tissues |
ExpressionAtlasi | Q58DH7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR006716, ERG2_sigma1_rcpt-like |
PANTHERi | PTHR10868, PTHR10868, 1 hit |
Pfami | View protein in Pfam PF04622, ERG2_Sigma1R, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SGMR1_BOVIN | |
Accessioni | Q58DH7Primary (citable) accession number: Q58DH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | April 26, 2005 | |
Last modified: | September 29, 2021 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families