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Protein

Syndecan-2

Gene

SDC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-BTA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-BTA-2022928 HS-GAG biosynthesis
R-BTA-2024096 HS-GAG degradation
R-BTA-202733 Cell surface interactions at the vascular wall
R-BTA-3000170 Syndecan interactions
R-BTA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-3928662 EPHB-mediated forward signaling
R-BTA-8957275 Post-translational protein phosphorylation
R-BTA-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-2
Short name:
SYND2
Alternative name(s):
CD_antigen: CD362
Gene namesi
Name:SDC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:34379 SDC2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 148ExtracellularSequence analysisAdd BLAST126
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 202CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000022754223 – 202Syndecan-2Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi55O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi57O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Modified residuei188PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei143 – 144Cleavage of ectodomainSequence analysis2

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ58DD4
PeptideAtlasiQ58DD4
PRIDEiQ58DD4

Expressioni

Gene expression databases

BgeeiENSBTAG00000014357 Expressed in 10 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Interacts (via cytoplasmic domain) with SARM1. Forms a complex with SDCBP and PDCD6IP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019090

Structurei

3D structure databases

ProteinModelPortaliQ58DD4
SMRiQ58DD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW5I Eukaryota
ENOG4111QSA LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000263414
HOVERGENiHBG004501
InParanoidiQ58DD4
KOiK16336
OMAiMQRAWIL
OrthoDBiEOG091G0OOE
TreeFamiTF320463

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031201 Syndecan-2
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF6 PTHR10915:SF6, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58DD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRAWILLTW VLVACVSAES RAELTSDKDM YLDNNSIEEA SGVYPIDDDD
60 70 80 90 100
YASASGSGAG EDGESPELTT SRPIPKIPFT STAPRVETTT LSKIQDKIPA
110 120 130 140 150
QTKSPEEIDK EKVHLPDSER KTDPAEEDTN VYTEKHSDNL FKRTEVLAAV
160 170 180 190 200
IAGGVIGFLF AIFLILLLVY RMRKKDEGSY DLGERKPSSA AYQKAPTKEF

YA
Length:202
Mass (Da):22,399
Last modified:April 26, 2005 - v1
Checksum:i7E855A0BFFA65B86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125A → D in AAI12469 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021663 mRNA Translation: AAX46510.1
BC112468 mRNA Translation: AAI12469.1
RefSeqiNP_001029960.2, NM_001034788.2
UniGeneiBt.11462

Genome annotation databases

EnsembliENSBTAT00000019090; ENSBTAP00000019090; ENSBTAG00000014357
GeneIDi615785
KEGGibta:615785

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021663 mRNA Translation: AAX46510.1
BC112468 mRNA Translation: AAI12469.1
RefSeqiNP_001029960.2, NM_001034788.2
UniGeneiBt.11462

3D structure databases

ProteinModelPortaliQ58DD4
SMRiQ58DD4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019090

Proteomic databases

PaxDbiQ58DD4
PeptideAtlasiQ58DD4
PRIDEiQ58DD4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019090; ENSBTAP00000019090; ENSBTAG00000014357
GeneIDi615785
KEGGibta:615785

Organism-specific databases

CTDi6383
VGNCiVGNC:34379 SDC2

Phylogenomic databases

eggNOGiENOG410IW5I Eukaryota
ENOG4111QSA LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000263414
HOVERGENiHBG004501
InParanoidiQ58DD4
KOiK16336
OMAiMQRAWIL
OrthoDBiEOG091G0OOE
TreeFamiTF320463

Enzyme and pathway databases

ReactomeiR-BTA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-BTA-2022928 HS-GAG biosynthesis
R-BTA-2024096 HS-GAG degradation
R-BTA-202733 Cell surface interactions at the vascular wall
R-BTA-3000170 Syndecan interactions
R-BTA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-3928662 EPHB-mediated forward signaling
R-BTA-8957275 Post-translational protein phosphorylation
R-BTA-975634 Retinoid metabolism and transport

Gene expression databases

BgeeiENSBTAG00000014357 Expressed in 10 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031201 Syndecan-2
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF6 PTHR10915:SF6, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDC2_BOVIN
AccessioniPrimary (citable) accession number: Q58DD4
Secondary accession number(s): Q2KIX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: April 26, 2005
Last modified: September 12, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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