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Protein

Notchless protein homolog 1

Gene

NLE1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processNotch signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Notchless protein homolog 1
Gene namesi
Name:NLE1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:32109 NLE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510971 – 486Notchless protein homolog 1Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ58D20
PRIDEiQ58D20

Expressioni

Gene expression databases

BgeeiENSBTAG00000019094 Expressed in 10 organ(s), highest expression level in heart

Interactioni

Subunit structurei

Associates with the pre-60S ribosomal particle. Interacts (via WD repeats) with uL18 (By similarity). Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain) (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025423

Structurei

3D structure databases

ProteinModelPortaliQ58D20
SMRiQ58D20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati113 – 152WD 1Sequence analysisAdd BLAST40
Repeati155 – 194WD 2Sequence analysisAdd BLAST40
Repeati198 – 242WD 3Sequence analysisAdd BLAST45
Repeati245 – 283WD 4Sequence analysisAdd BLAST39
Repeati326 – 367WD 5Sequence analysisAdd BLAST42
Repeati371 – 410WD 6Sequence analysisAdd BLAST40
Repeati413 – 452WD 7Sequence analysisAdd BLAST40
Repeati455 – 486WD 8Sequence analysisAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 97Ubiquitin-like (UBL) domainBy similarityAdd BLAST83

Sequence similaritiesi

Belongs to the NLE1/RSA4 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0271 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00810000125363
HOGENOMiHOG000091641
HOVERGENiHBG007602
InParanoidiQ58D20
KOiK14855
OMAiLNTETPH
OrthoDBiEOG091G05DP
TreeFamiTF300668

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR012972 NLE
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08154 NLE, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q58D20-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAAADEA ATRDVQRLLV QFQDEGGQLL GSPFDVPVDI TPDKLQLVCN
60 70 80 90 100
ALLAQEDPLP LAFYVHDAEI VSSLGRTLES QAVETEKVLD IIYQPQAIFR
110 120 130 140 150
VRAVTRCTSS LEGHSEAVIS VAFSPTGKYL ASGSGDTTVR FWDLSTETPH
160 170 180 190 200
FTCQGHRHWV LSISWSPDGK KLASGCKNGQ ILLWDPSTGK QVGRALTGHS
210 220 230 240 250
KWITALSWEP LHANPECRYV ASSSKDGSVR VWDTTAGRCE RTLTGHAQSV
260 270 280 290 300
TCLRWGGDGL LYSASQDRTI KVWRAHDGVL CRTLQGHGHW VNTMALSTDY
310 320 330 340 350
ALRTGAFEPA EASVNAQDLR GSLQELKERA LSRYNLVRGQ GPERLVSGSD
360 370 380 390 400
DFTLFLWSPA EDKKPLARMT GHQALINQVV FSPDSRVIAS ASFDKSIKLW
410 420 430 440 450
DGRTGKYLAS LRGHVAAVYQ IAWSADSRLL VSGSSDSTLK VWDVKAQKLS
460 470 480
TDLPGHADEV YAVDWSPDGQ RVASGGKDKC LRIWRR
Length:486
Mass (Da):53,229
Last modified:March 6, 2013 - v3
Checksum:iB4C6A5B21FC24CDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021777 mRNA Translation: AAX46624.1
RefSeqiNP_001014887.1, NM_001014887.1
UniGeneiBt.22388

Genome annotation databases

EnsembliENSBTAT00000025423; ENSBTAP00000025423; ENSBTAG00000019094
GeneIDi509793
KEGGibta:509793

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021777 mRNA Translation: AAX46624.1
RefSeqiNP_001014887.1, NM_001014887.1
UniGeneiBt.22388

3D structure databases

ProteinModelPortaliQ58D20
SMRiQ58D20
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025423

Proteomic databases

PaxDbiQ58D20
PRIDEiQ58D20

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000025423; ENSBTAP00000025423; ENSBTAG00000019094
GeneIDi509793
KEGGibta:509793

Organism-specific databases

CTDi54475
VGNCiVGNC:32109 NLE1

Phylogenomic databases

eggNOGiKOG0271 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00810000125363
HOGENOMiHOG000091641
HOVERGENiHBG007602
InParanoidiQ58D20
KOiK14855
OMAiLNTETPH
OrthoDBiEOG091G05DP
TreeFamiTF300668

Gene expression databases

BgeeiENSBTAG00000019094 Expressed in 10 organ(s), highest expression level in heart

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR012972 NLE
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08154 NLE, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNLE1_BOVIN
AccessioniPrimary (citable) accession number: Q58D20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 6, 2013
Last modified: November 7, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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