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Protein

Tripartite motif-containing protein 54

Gene

TRIM54

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May bind and stabilize microtubules during myotubes formation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 82RING-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri121 – 163B box-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 54
Gene namesi
Name:TRIM54
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:36340 TRIM54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562811 – 366Tripartite motif-containing protein 54Add BLAST366

Proteomic databases

PaxDbiQ58D15
PRIDEiQ58D15

Expressioni

Gene expression databases

BgeeiENSBTAG00000018267

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with TRIM63 and probably with TRIM55. Interacts with tubulin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024312

Structurei

3D structure databases

ProteinModelPortaliQ58D15
SMRiQ58D15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini271 – 329COSPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 211Mediates microtubule-binding and homooligomerizationBy similarityAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili185 – 258Sequence analysisAdd BLAST74

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 82RING-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri121 – 163B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410KDQF Eukaryota
ENOG410YBZG LUCA
GeneTreeiENSGT00760000118878
HOGENOMiHOG000231156
HOVERGENiHBG071242
InParanoidiQ58D15
KOiK10653
OMAiSMEQFSV
OrthoDBiEOG091G071N
TreeFamiTF331669

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR017903 COS_domain
IPR033492 TRIM54
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR44026:SF4 PTHR44026:SF4, 1 hit
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS51262 COS, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q58D15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC
60 70 80 90 100
ANDVFQASNP LWQSRSSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL
110 120 130 140 150
VENIIDIYKQ ESSRPLHSKA EQHLMCEEHE DEKINIYCLS CEVPTCSLCK
160 170 180 190 200
VFGAHKDCEV APLPTIYKRQ KSELSDGIAM LVAGNDRVQA VITQMEEVCQ
210 220 230 240 250
TIEENSRRQK QLLNQRFEGL CAVLEERKGE LLQALAREQE EKLQRVRGLI
260 270 280 290 300
RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GTMSKVELAG
310 320 330 340 350
RPEPGYERMD QFTVSVEHVA EMLRTIDFQP GTSGEEEDEE VAVEGEEGNA
360
GPEEERTDGR ESTGQH
Length:366
Mass (Da):41,337
Last modified:April 26, 2005 - v1
Checksum:i9058297044439497
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021782 mRNA Translation: AAX46629.1
BC114171 mRNA Translation: AAI14172.1
RefSeqiNP_001017951.1, NM_001017951.1
UniGeneiBt.9981

Genome annotation databases

EnsembliENSBTAT00000024312; ENSBTAP00000024312; ENSBTAG00000018267
GeneIDi535320
KEGGibta:535320

Similar proteinsi

Entry informationi

Entry nameiTRI54_BOVIN
AccessioniPrimary (citable) accession number: Q58D15
Secondary accession number(s): Q29RH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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