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Protein

Tyrosine aminotransferase

Gene

TAT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine (By similarity).By similarity

Catalytic activityi

L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.

Cofactori

Pathwayi: L-phenylalanine degradation

This protein is involved in step 2 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Phenylalanine-4-hydroxylase (PAH)
  2. Tyrosine aminotransferase (TAT)
  3. 4-hydroxyphenylpyruvate dioxygenase (HPD)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Fumarylacetoacetase (FAH)
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00139; UER00338

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine aminotransferase (EC:2.6.1.5)
Short name:
TAT
Alternative name(s):
L-tyrosine:2-oxoglutarate aminotransferase
Gene namesi
Name:TAT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475371 – 447Tyrosine aminotransferaseAdd BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei441PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ58CZ9
PRIDEiQ58CZ9

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002866

Structurei

3D structure databases

ProteinModelPortaliQ58CZ9
SMRiQ58CZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0259 Eukaryota
COG0436 LUCA
HOGENOMiHOG000239005
HOVERGENiHBG004318
InParanoidiQ58CZ9
KOiK00815

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR011715 Tyr_aminoTrfase_ubiquitination
IPR005958 TyrNic_aminoTrfase
IPR005957 Tyrosine_aminoTrfase
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PF07706 TAT_ubiq, 1 hit
PIRSFiPIRSF000517 Tyr_transaminase, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01264 tyr_amTase_E, 1 hit
TIGR01265 tyr_nico_aTase, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q58CZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDHGSLPSV LDVHVNVAGR SSVLGKVKSR KARWSVRPSD MSNKTFNPIR
60 70 80 90 100
AIVDNMKVKP NPNKTMIALS IGDPTVFGNL PTDPEVTQAM KDALDSGKFN
110 120 130 140 150
GYVPSIGYLS SREEVASYYH CPEAPLEAKD VILTSGCSQA IELCLAVLAN
160 170 180 190 200
PGQNILVPRP GFSLYRTLAE SMGIEVKLYN LLPEKNWEID LKQLESLIDE
210 220 230 240 250
KTVCLIVNNP SNPCGSVFSR RHLQKILAVA ARQCVPILAD EIYGDMVFSD
260 270 280 290 300
SKFEPLATLS SKVPILSCGG LAKRWLVPGW RMGWILIHDR RDIFGNEIRD
310 320 330 340 350
GLTKLSQRIL GPCTLVQGAL KSILCRTPRV FYHNTLSFLK SNADLCYGAL
360 370 380 390 400
AAIPGLRPIH PSGAMYLMVG IEMEHFPEFE NDVEFTEQLV AEQSVHCLPA
410 420 430 440
TCFEYPNFFR VVITVPEVMM LEACSRIQEF CEQHYHCAEG SQEECDK
Length:447
Mass (Da):49,691
Last modified:April 26, 2005 - v1
Checksum:iA26B57A6B8CF656E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021798 mRNA Translation: AAX46645.1
RefSeqiNP_001029762.1, NM_001034590.1
UniGeneiBt.23731

Genome annotation databases

GeneIDi533481
KEGGibta:533481

Similar proteinsi

Entry informationi

Entry nameiATTY_BOVIN
AccessioniPrimary (citable) accession number: Q58CZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 26, 2005
Last modified: April 25, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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