UniProtKB - Q58CX9 (CBPC5_BOVIN)
Protein
Cytosolic carboxypeptidase-like protein 5
Gene
AGBL5
Organism
Bos taurus (Bovine)
Status
Functioni
Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.By similarity
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 252 | ZincBy similarity | 1 | |
Metal bindingi | 255 | ZincBy similarity | 1 | |
Active sitei | 303 | NucleophileBy similarity | 1 | |
Metal bindingi | 434 | ZincBy similarity | 1 |
GO - Molecular functioni
- metallocarboxypeptidase activity Source: UniProtKB
- tubulin binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- defense response to virus Source: UniProtKB
- protein branching point deglutamylation Source: UniProtKB
- protein deglutamylation Source: UniProtKB
Keywordsi
Molecular function | Carboxypeptidase, Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Cytosolic carboxypeptidase-like protein 5 (EC:3.4.17.-)Alternative name(s): ATP/GTP-binding protein-like 5 |
Gene namesi | Name:AGBL5 Synonyms:CCP5 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:25723, AGBL5 |
Subcellular locationi
Cytosol
- cytosol By similarity
Nucleus
- Nucleus By similarity
Cytoskeleton
- spindle By similarity
Other locations
- Midbody By similarity
Note: Mainly cytoplasmic. Slight accumulation in the nucleus is observed. Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.By similarity
Cytoskeleton
- mitotic spindle Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- intercellular bridge Source: Ensembl
Nucleus
- nucleus Source: UniProtKB
Other locations
- midbody Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305920 | 1 – 885 | Cytosolic carboxypeptidase-like protein 5Add BLAST | 885 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 840 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q58CX9 |
PRIDEi | Q58CX9 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000013403, Expressed in spermatid and 17 other tissues |
ExpressionAtlasi | Q58CX9, baseline and differential |
Interactioni
GO - Molecular functioni
- tubulin binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000017831 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 540 – 544 | Poly-Pro | 5 | |
Compositional biasi | 599 – 756 | Ser-richAdd BLAST | 158 |
Sequence similaritiesi
Belongs to the peptidase M14 family.Curated
Phylogenomic databases
eggNOGi | KOG3641, Eukaryota |
GeneTreei | ENSGT00940000158032 |
HOGENOMi | CLU_007523_3_2_1 |
InParanoidi | Q58CX9 |
OMAi | WFHFSVR |
OrthoDBi | 481670at2759 |
TreeFami | TF324301 |
Family and domain databases
InterProi | View protein in InterPro IPR040626, Pepdidase_M14_N IPR000834, Peptidase_M14 |
Pfami | View protein in Pfam PF18027, Pepdidase_M14_N, 1 hit PF00246, Peptidase_M14, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q58CX9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELRCGGLLF SSRFDSGNLA HVEKVESVSN DGEGVAGGAS ASTSSIASSP
60 70 80 90 100
DYEFNVWTRP DCAETEFENG NRSWFYFSVR GGTPGKLIKI NIMNMNKQSK
110 120 130 140 150
LYSQGMAPFV RTLPTRPRWE RIRDRPTFEM TETQFVLSFI HRFVEGRGAT
160 170 180 190 200
TFFAFCYPFS YSDCQDLLSQ LDQRFLENSP THSSPLDTIY YHRETLCYSL
210 220 230 240 250
DGLRVDLLTI SSCHGLREDR EPRLEQLFPD ASTPRPFRFT GKRIFFLSSR
260 270 280 290 300
VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG
310 320 330 340 350
HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNSQSPSEH
360 370 380 390 400
QHSSHLPPDA PLSDPEKADS LQNRAHLGRS SSGDKPEAWT QTEVAEQKPN
410 420 430 440 450
SVWITPQESA EVEQLAPDAI PPRESGVAYY VDLHGHASKR GCFMYGNSFS
460 470 480 490 500
DENTQVENML YPKLISLNSA HFDFQGCNFS EKNMYARDRR DGQSKEGSGR
510 520 530 540 550
VAIYKASGII HSYTLECNYN TGRSVNSIPA ACHDNGRASP PPPPAFPSRY
560 570 580 590 600
TVELFEQVGR AMAIAALDMA ECNPWPRIVL SEHSSLTNLR AWMLKHVRSS
610 620 630 640 650
RGLSTTVNMS ISKKRGSRTP PRSNNGLPVS CSENTLSRAR SFSTGTSAGG
660 670 680 690 700
SSSSQQNSPQ MKNSPSFPFH GSRPAGLPGL GSSTQKVSHR VLGPVREPRS
710 720 730 740 750
QDRRRRQQPV THRPTSSSLA PSPTPASSNL ASSHMGSCLL PNSLSISGSS
760 770 780 790 800
CSFLSSGDKT EAVMVIGKGL LGAGPRIPCI RTRLQARPRL AQGSPPTRRG
810 820 830 840 850
MRGSPGPTSP IPQTKKSSEP ELGPRCTPRL PQAGPPRPCS APAFSPISCS
860 870 880
LSDSQSRICY SGGPLGQTEV CFVPKSPPFT VSPRV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MYW4 | A0A3Q1MYW4_BOVIN | Cytosolic carboxypeptidase-like pro... | AGBL5 | 816 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 – 13 | SR → CG in AAX46665 (PubMed:16305752).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040426 | 697 – 885 | EPRSQ…VSPRV → GKLVWEPLQQVFGCLGHCWG K in isoform 2. 2 PublicationsAdd BLAST | 189 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021818 mRNA Translation: AAX46665.1 AAFC03088657 Genomic DNA No translation available. BC126504 mRNA Translation: AAI26505.1 |
RefSeqi | NP_001019735.1, NM_001024564.1 XP_005213081.1, XM_005213024.3 [Q58CX9-1] |
Genome annotation databases
Ensembli | ENSBTAT00000017831; ENSBTAP00000017831; ENSBTAG00000013403 [Q58CX9-2] ENSBTAT00000079929; ENSBTAP00000067922; ENSBTAG00000013403 [Q58CX9-1] |
GeneIDi | 538585 |
KEGGi | bta:538585 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021818 mRNA Translation: AAX46665.1 AAFC03088657 Genomic DNA No translation available. BC126504 mRNA Translation: AAI26505.1 |
RefSeqi | NP_001019735.1, NM_001024564.1 XP_005213081.1, XM_005213024.3 [Q58CX9-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000017831 |
Proteomic databases
PaxDbi | Q58CX9 |
PRIDEi | Q58CX9 |
Genome annotation databases
Ensembli | ENSBTAT00000017831; ENSBTAP00000017831; ENSBTAG00000013403 [Q58CX9-2] ENSBTAT00000079929; ENSBTAP00000067922; ENSBTAG00000013403 [Q58CX9-1] |
GeneIDi | 538585 |
KEGGi | bta:538585 |
Organism-specific databases
CTDi | 60509 |
VGNCi | VGNC:25723, AGBL5 |
Phylogenomic databases
eggNOGi | KOG3641, Eukaryota |
GeneTreei | ENSGT00940000158032 |
HOGENOMi | CLU_007523_3_2_1 |
InParanoidi | Q58CX9 |
OMAi | WFHFSVR |
OrthoDBi | 481670at2759 |
TreeFami | TF324301 |
Gene expression databases
Bgeei | ENSBTAG00000013403, Expressed in spermatid and 17 other tissues |
ExpressionAtlasi | Q58CX9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR040626, Pepdidase_M14_N IPR000834, Peptidase_M14 |
Pfami | View protein in Pfam PF18027, Pepdidase_M14_N, 1 hit PF00246, Peptidase_M14, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CBPC5_BOVIN | |
Accessioni | Q58CX9Primary (citable) accession number: Q58CX9 Secondary accession number(s): A1A4I0, E1B7H7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 85 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries