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Entry version 73 (02 Jun 2021)
Sequence version 1 (26 Apr 2005)
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Protein

Dolichol kinase

Gene

DOLK

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-446199, Synthesis of Dolichyl-phosphate

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dolichol kinase (EC:2.7.1.108)
Alternative name(s):
Transmembrane protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOLK
Synonyms:TMEM15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:28170, DOLK

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 18LumenalSequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 74CytoplasmicSequence analysisAdd BLAST35
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 111LumenalSequence analysisAdd BLAST16
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 134CytoplasmicSequence analysis2
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 163LumenalSequence analysis8
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 188CytoplasmicSequence analysis4
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 224LumenalSequence analysisAdd BLAST15
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 254CytoplasmicSequence analysis9
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 297LumenalSequence analysisAdd BLAST22
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 337CytoplasmicSequence analysisAdd BLAST19
Transmembranei338 – 354HelicalSequence analysisAdd BLAST17
Topological domaini355 – 359LumenalSequence analysis5
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Topological domaini381 – 401CytoplasmicSequence analysisAdd BLAST21
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 436LumenalSequence analysisAdd BLAST14
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 472CytoplasmicSequence analysisAdd BLAST15
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 495LumenalSequence analysis2
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 538CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002389311 – 538Dolichol kinaseAdd BLAST538

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q58CR4

PRoteomics IDEntifications database

More...
PRIDEi
Q58CR4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000010601, Expressed in kidney and 97 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000054607

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni459 – 474CTP-bindingBy similarityAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polyprenol kinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2468, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004067

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027611_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q58CR4

Identification of Orthologs from Complete Genome Data

More...
OMAi
RKYFHFI

Database of Orthologous Groups

More...
OrthoDBi
1533260at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323379

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026566, DOLK
IPR032974, Polypren_kinase

The PANTHER Classification System

More...
PANTHERi
PTHR13205, PTHR13205, 1 hit
PTHR13205:SF15, PTHR13205:SF15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q58CR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRECAPPTP GSGAPLSGSV LAEAAVVFVV VLSIHAAVWD RYSWCAVALA
60 70 80 90 100
VQAFYVQYKW DRLLQQGSAV FQFRMSANSG LLPASVVMPL LGLVMKERCQ
110 120 130 140 150
AAGNPYFERF GIVVAATGMA VALFSSVLAL GITRPVPTNT CVISGLAGGV
160 170 180 190 200
IIYIMKHSLS VGEVIEVLEA LLIFVYLNMI LLYLLPRCFT PGEALLVLGG
210 220 230 240 250
ISFMLNQLIK RSLTVVESQG DPLDFFLLVV VVGMVLMGIF FSTLFVFMDS
260 270 280 290 300
GTWASSIFFH LMTCVLGLGV VLPWLHRLIR RNPLLWLFQF LFQTETRVYL
310 320 330 340 350
LAYWCLLATV ACLVVLYQNA KRSSSESKKH QAPTITRKYF HFIVVATYIP
360 370 380 390 400
GIILDRPLLY VAATVCLAVF IFLEYVRYFR IKPLGHTLRS LLSLFLDERD
410 420 430 440 450
SGPLILTHIY LLLGMSLPIW LVPRPCTQKG SLGGARALVP YAGVLAVGVG
460 470 480 490 500
DTVASIFGST MGEIRWPGTK KTFEGTMTSI FAQIISVALI LIFDSGVDLN
510 520 530
YSYAWILGSI STVSLLEAYT TQIDNLLLPL YLLILLMA
Length:538
Mass (Da):59,190
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E8619DC63E57929
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAX46357 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BT021510 mRNA Translation: AAX46357.1 Frameshift.
BT021883 mRNA Translation: AAX46730.1
BC126569 mRNA Translation: AAI26570.1

NCBI Reference Sequences

More...
RefSeqi
NP_001030442.2, NM_001035365.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000014016; ENSBTAP00000054607; ENSBTAG00000010601

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
526844

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:526844

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021510 mRNA Translation: AAX46357.1 Frameshift.
BT021883 mRNA Translation: AAX46730.1
BC126569 mRNA Translation: AAI26570.1
RefSeqiNP_001030442.2, NM_001035365.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054607

Proteomic databases

PaxDbiQ58CR4
PRIDEiQ58CR4

Genome annotation databases

EnsembliENSBTAT00000014016; ENSBTAP00000054607; ENSBTAG00000010601
GeneIDi526844
KEGGibta:526844

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22845
VGNCiVGNC:28170, DOLK

Phylogenomic databases

eggNOGiKOG2468, Eukaryota
GeneTreeiENSGT00390000004067
HOGENOMiCLU_027611_2_1_1
InParanoidiQ58CR4
OMAiRKYFHFI
OrthoDBi1533260at2759
TreeFamiTF323379

Enzyme and pathway databases

ReactomeiR-BTA-446199, Synthesis of Dolichyl-phosphate

Gene expression databases

BgeeiENSBTAG00000010601, Expressed in kidney and 97 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR026566, DOLK
IPR032974, Polypren_kinase
PANTHERiPTHR13205, PTHR13205, 1 hit
PTHR13205:SF15, PTHR13205:SF15, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOLK_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q58CR4
Secondary accession number(s): A0JN90, Q58DT7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: April 26, 2005
Last modified: June 2, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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