UniProtKB - Q58CQ2 (ARC1B_BOVIN)
Actin-related protein 2/3 complex subunit 1B
ARPC1B
Functioni
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
By similarityGO - Molecular functioni
- actin filament binding Source: GO_Central
GO - Biological processi
- Arp2/3 complex-mediated actin nucleation Source: GO_Central
- regulation of actin filament polymerization Source: InterPro
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
Reactomei | R-BTA-2029482, Regulation of actin dynamics for phagocytic cup formation R-BTA-5663213, RHO GTPases Activate WASPs and WAVEs |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-related protein 2/3 complex subunit 1BAlternative name(s): Arp2/3 complex 41 kDa subunit p41-ARC |
Gene namesi | Name:ARPC1B |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000046248 |
VGNCi | VGNC:26164, ARPC1B |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Nucleus
- Nucleus By similarity
Cytoskeleton
- Arp2/3 protein complex Source: GO_Central
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239701 | 1 – 372 | Actin-related protein 2/3 complex subunit 1BAdd BLAST | 372 |
Proteomic databases
PaxDbi | Q58CQ2 |
PeptideAtlasi | Q58CQ2 |
PRIDEi | Q58CQ2 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000046248, Expressed in leukocyte and 99 other tissues |
Interactioni
Subunit structurei
Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
2 PublicationsGO - Molecular functioni
- actin filament binding Source: GO_Central
Protein-protein interaction databases
DIPi | DIP-29791N |
IntActi | Q58CQ2, 8 interactors |
STRINGi | 9913.ENSBTAP00000056302 |
Structurei
Secondary structure
3D structure databases
SMRi | Q58CQ2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q58CQ2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 6 – 45 | WD 1Add BLAST | 40 | |
Repeati | 50 – 89 | WD 2Add BLAST | 40 | |
Repeati | 94 – 135 | WD 3Add BLAST | 42 | |
Repeati | 140 – 179 | WD 4Add BLAST | 40 | |
Repeati | 242 – 280 | WD 5Add BLAST | 39 | |
Repeati | 324 – 367 | WD 6Add BLAST | 44 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1523, Eukaryota |
GeneTreei | ENSGT00950000183183 |
HOGENOMi | CLU_034396_1_0_1 |
InParanoidi | Q58CQ2 |
OMAi | KWVQVHE |
OrthoDBi | 848569at2759 |
TreeFami | TF315041 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR030141, ARC1B IPR017383, ARPC1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10709, PTHR10709, 1 hit PTHR10709:SF10, PTHR10709:SF10, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
PIRSFi | PIRSF038093, ARP2/3_su1, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGN KWVQVHELKE
60 70 80 90 100
HNGQVTGIDW APDSNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR
110 120 130 140 150
CVRWAPNEKK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNSVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS
210 220 230 240 250
SCGWVHGVCF SANGSRVAWV SHDSTVCLAD ADKKMAVATL ASETLPLLAV
260 270 280 290 300
TFITESSLVA AGHDCFPVLF TYDSAAGKLS FGGRLDVPKQ SSQRGLTARE
310 320 330 340 350
RFQNLDKKAS SEGSAAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM
360 370
DGGMSIWDVR SLESALKDLK IV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 | R → H in AAX46742 (PubMed:16305752).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021526 mRNA Translation: AAX46373.1 BT021895 mRNA Translation: AAX46742.1 BT026160 mRNA Translation: ABG66999.1 BC102942 mRNA Translation: AAI02943.1 |
RefSeqi | NP_001014844.1, NM_001014844.3 |
Genome annotation databases
Ensembli | ENSBTAT00000064158; ENSBTAP00000056302; ENSBTAG00000046248 |
GeneIDi | 326600 |
KEGGi | bta:326600 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021526 mRNA Translation: AAX46373.1 BT021895 mRNA Translation: AAX46742.1 BT026160 mRNA Translation: ABG66999.1 BC102942 mRNA Translation: AAI02943.1 |
RefSeqi | NP_001014844.1, NM_001014844.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1K8K | X-ray | 2.00 | C | 1-372 | [»] | |
1TYQ | X-ray | 2.55 | C | 1-372 | [»] | |
1U2V | X-ray | 2.55 | C | 1-372 | [»] | |
2P9I | X-ray | 2.46 | C | 1-372 | [»] | |
2P9K | X-ray | 2.59 | C | 1-372 | [»] | |
2P9L | X-ray | 2.65 | C | 1-372 | [»] | |
2P9N | X-ray | 2.85 | C | 1-372 | [»] | |
2P9P | X-ray | 2.90 | C | 1-372 | [»] | |
2P9S | X-ray | 2.68 | C | 1-372 | [»] | |
2P9U | X-ray | 2.75 | C | 1-372 | [»] | |
3DXK | X-ray | 2.70 | C | 1-372 | [»] | |
3DXM | X-ray | 2.85 | C | 1-372 | [»] | |
3RSE | X-ray | 2.65 | C | 1-372 | [»] | |
3UKR | X-ray | 2.48 | C | 1-372 | [»] | |
3UKU | X-ray | 2.75 | C | 1-372 | [»] | |
3ULE | X-ray | 2.50 | C | 1-372 | [»] | |
4JD2 | X-ray | 3.08 | C | 1-372 | [»] | |
4XEI | X-ray | 3.87 | C | 1-372 | [»] | |
4XF2 | X-ray | 5.00 | C/V | 1-372 | [»] | |
6DEC | X-ray | 4.60 | C/J | 1-372 | [»] | |
SMRi | Q58CQ2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-29791N |
IntActi | Q58CQ2, 8 interactors |
STRINGi | 9913.ENSBTAP00000056302 |
Proteomic databases
PaxDbi | Q58CQ2 |
PeptideAtlasi | Q58CQ2 |
PRIDEi | Q58CQ2 |
Genome annotation databases
Ensembli | ENSBTAT00000064158; ENSBTAP00000056302; ENSBTAG00000046248 |
GeneIDi | 326600 |
KEGGi | bta:326600 |
Organism-specific databases
CTDi | 10095 |
VEuPathDBi | HostDB:ENSBTAG00000046248 |
VGNCi | VGNC:26164, ARPC1B |
Phylogenomic databases
eggNOGi | KOG1523, Eukaryota |
GeneTreei | ENSGT00950000183183 |
HOGENOMi | CLU_034396_1_0_1 |
InParanoidi | Q58CQ2 |
OMAi | KWVQVHE |
OrthoDBi | 848569at2759 |
TreeFami | TF315041 |
Enzyme and pathway databases
Reactomei | R-BTA-2029482, Regulation of actin dynamics for phagocytic cup formation R-BTA-5663213, RHO GTPases Activate WASPs and WAVEs |
Miscellaneous databases
EvolutionaryTracei | Q58CQ2 |
Gene expression databases
Bgeei | ENSBTAG00000046248, Expressed in leukocyte and 99 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR030141, ARC1B IPR017383, ARPC1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10709, PTHR10709, 1 hit PTHR10709:SF10, PTHR10709:SF10, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
PIRSFi | PIRSF038093, ARP2/3_su1, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARC1B_BOVIN | |
Accessioni | Q58CQ2Primary (citable) accession number: Q58CQ2 Secondary accession number(s): Q0V8Q8, Q58DS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 129 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families